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Biomedical subjects

R Rasenack

Publications and source records attributed to R Rasenack.

11 recordsLinked to original sources
PubMed1991

[Fetomaternal transfusions in complicated and uncomplicated pregnancy].

Fetomaternal bleeding in pregnancy is the most common cause of rhesus immunization. In this study we evaluated the amount of fetomaternal bleeding during pregnancies with and without complications. The data from 1204 patients are analyzed. Fetomaternal bleeding was of clinical relevance (HbF greater than 0.01%) in 6% of all uncomplicated pregnancies. There was no increased fetomaternal bleeding in pregnancies complicated by gestosis, preliminary labour, placenta praevia, trauma, and diabetes in pregnancy. In cases with premature rupture of the amnion or vaginal bleeding in pregnancy we observed an increased percentage of fetomaternal bleeding into the mother's circulation. Nearly 25% of all patients with hydrops fetalis had clinical relevant fetomaternal bleeding (HbF greater than 0.01%).

Adolescent↗
PubMed1991

[Fetomaternal transfusion in relation to mode of delivery. Comparison of data from the DFG multicenter study "Rhesus negative" (1965-70) with data from the Freiburg University Gynecologic Clinic (1989)].

Fetomaternal hemorrhage with transfusion of more than 10-25 ml fetal blood into the maternal circulation ("macrotransfusion") is one possible cause of the failure of combined pre- and postpartal anti-D prophylaxis. We analyzed the data from 391 patients who delivered at the UFK Freiburg in 1989. We evaluated the amount of fetomaternal bleeding in different modes of delivery. We observed fetomaternal hemorrhage of clinical relevance in 7.5% of spontaneous delivery, 11.1% of vacuum extraction, 17.7% of cesarean section (p less than 0.05). There was no difference concerning macrotransfusions in the above mentioned modes of delivery. Our data are compared with the data of the DFG multicenter trial "rhesus negative" (1965-79).

Cesarean Section↗
PubMed1986

[Prognosis of pregnancy in diabetes mellitus].

From 1970-1984 116 pregnant diabetic patients were monitored and delivered at the University Hospital of Freiburg, Department of Obstetrics and Gynecology. During these 15 years, a decrease in maternal and fetal complications was observed. Today the risk of some complications in diabetic pregnancy is not greater than that of pregnancy in nondiabetic women. There is, however, still a higher incidence of gestosis and polyhydramnion in diabetics. The main fetal risk is macrosomia. There is an increasing tendency to spontaneous delivery near term. Today incidence rate of caesarean sections is below 30%.

Birth Weight↗
PubMed1985

[Rhesus erythroblastosis, monitoring and treatment].

From 1975-1984 92 pregnancies with suspicion of a morbus hemolyticus fetalis were monitored at the University Hospital of Freiburg, Department of Obstetrics and Gynecology. Most of the patients had antibodies against the rhesusfactor D. Amniocentesis was carried out regularly; the bilirubin level and protein content of the amniotic fluid were measured using chemical methods and the bilirubin/protein ratio was determined. The results obtained correlated well with the values of spectrophotometrically measured bilirubin, which reliably indicated the severity of the hemolytic disease. A serious erythroblastosis was observed in 17 cases. Four children died before any treatment was initiated. In 13 children 37 intrauterine transfusions (IUT) were performed. The survival rate of the children with IUT's was 69%, in nonhydropic children it was 82%. The mortality risk of the IUT was low. Children with IUT's often showed complications in the perinatal period, which were due to the premature birth and the erythroblastosis.

Amniocentesis↗
PubMed1980

[The mean blood pressure in the second trimester (map-2) as a valuable aid in the early recognition of the pregnancies with a risk of hypertension (author's transl)].

The mean blood pressure in the second trimester of pregnancy was calculated with a formula (Formula: see text) which stands for systolic pressure plus twice diastolic pressure divided by 3 equals mmHg. In 285 patients 43% had a MPA-2 value of 85 mmHg. or higher. At this threshold value 89% of all later hypertensions were recognized. An MAP-2 value of 90 mmHg. was found in 21% of the patients. In this group 63% became hypertensive. However, this group contained 10 of the 11 moderately severe and severe cases. In the outcome of the pregnancies there was a significant increase in prepathological fetal monitoring changes and a significant increase in suspicious Apgar values. The calculation of the MAP-2 value should become a part of routine prenatal care.

Apgar Score↗
PubMedDate not supplied

Veno-occlusive disease in a fetus caused by pyrrolizidine alkaloids of food origin.

We report the occurrence of veno-occlusive disease in a preterm neonate who was symptomatic with hepatomegaly and ascites and was delivered by caesarean section for threatening fetal asphyxia and died shortly afterwards. Post mortem examination revealed veno-occlusive disease typical for pyrrolizidine alkaloid poisoning. The content of pyrrolizidine alkaloids in the liver could be confirmed. Analysis of a herbal mixture which was used for cooking in the family revealed high amounts of the respective alkaloids clarifying the source of the poison and the causal relationship.

Female↗
PubMedDate not supplied

[Fetomaternal transfusions in early pregnancy].

Fetomaternal bleeding is the major cause for rhesus immunization in pregnancy. This study evaluates the amount of fetomaternal bleeding in 345 pregnancies before 28th week of gestation. Fetomaternal bleeding was of clinical relevance (HbF greater than 0.015%) in 2.2% of all uncomplicated pregnancies. In case of abortion or vaginal bleeding in early pregnancy we observed a statistical significant increase of transplacental hemorrhage. The need for anti-D-prophylaxis in this patients is obvious.

Abortion, Spontaneous↗