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Biomedical subjects

R Raman

Publications and source records attributed to R Raman.

At least 127 records · Page 7Linked to original sources
PubMed1990

Role of 1q trisomy in tumorigenicity, growth, and metastasis of human leukemic B-cell clones in nude mice.

In order to investigate the association between various karyotypes of human tumor cells and biological behavior of tumors such as tumorigenicity, rate of growth, and the capacity to form metastasis, six chromosomally distinctive clones were isolated from an Epstein-Barr virus-transformed human chronic lymphocytic leukemic B-cell line which progressively grew and metastasized in irradiated nude mice. When inoculated into nude mice one clone (D10-1) with the karyotype of 46,XY,dup(1)(q11----q32) was more tumorigenic, grew faster, and produced more metastases than the other five clones. When mixtures of different clone-derived cells were grown in vitro or inoculated s.c. into nude mice the proportion of D10-1 cells was higher than their expected numbers in the cultures, s.c. tumors, and splenic and lymph nodal metastases. The growth and metastatic potential of the D10-1 clone were inhibited when cells from this clone were mixed with one or more clones that had slower growth. Duplication of 1q has been observed as a secondary aberration in human hematological malignancies and solid cancers. Our results demonstrate that duplication of the chromosome segment of 1q11----1q32 is associated with advantages in proliferation and metastasis formation.

Animals↗
PubMed1990

Pneumatization of the paranasal sinuses (maxillary and frontal) in cleft lip and palate.

A comparative study of roentgenograms of the paranasal sinuses between 37 patients with cleft lip and palate and 37 control subjects of the same age group was done using a planimeter. The results indicate that there is no statistical difference in the sizes. The paranasal sinuses increased in size with age in patients as well as in control subjects.

Adolescent↗
PubMed1989

Inherited nasal and laryngeal degenerative chondropathy.

Four rare cases of congenital saddle-nose deformity and slowly progressive degeneration of laryngeal cartilages with stenosis are described. The term inherited degenerative chondropathy is suggested for this disease entity. To our knowledge this is the first article on such a disease.

Adolescent↗
PubMed1989

Muscle receptors: content of some of the extrinsic and intrinsic muscles of the larynx in the bonnet monkey (Macaca radiata).

The number of muscle receptors and in particular the muscle spindle content of some of the intrinsic and extrinsic laryngeal muscles was evaluated, using bonnet monkeys (Macaca radiata). The technique of Barker and Ip [J. Physiol. (Lond) 169:73-74, 1963] was used to stain the muscle receptors. The results indicate that the intrinsic laryngeal muscles were devoid of muscle spindles. The extrinsic laryngeal muscles that were examined contain muscle spindles, though their density is less than that reported in the spindle-rich muscles like the rotators of the head and some of the intrinsic muscles of the hand (Cooper in: Structure and Function of Muscle, Vol. I, G.H. Bourne, ed, Academic Press, New York and London, 1960).

Animals↗
PubMed1989

A unilateral mesenchymal disorder of the head.

A hitherto undescribed group of lesions consisting of cystic bony lesions, exostosis, fibromatous lesion, unilateral tonsillar hypertrophy, epidermoid cyst (cholesteatoma) and hyperplasia of the mandible confined to the left side of the face is reported. The case may represent a variant of the Proteus syndrome.

Adult↗
PubMed1989

Vasomotor rhinitis--atrophic rhinitis: two ends of an autonomic spectrum.

A hypothesis is put forward based on clinical observations and treatment modalities in vasomotor non-allergic rhinitis (V.M.R.) and primary atrophic rhinitis (P.A.R.). The hypothesis postulates that (1) V.M.R. and P.A.R. are two diseases at the ends of an autonomic spectrum (2) The anterior nasal aperture, its dimensions and sensory receptors play a vital role in the etiopathogenesis of both the conditions through reflex autonomic action.

Humans↗
PubMed1989

Microscopically diagnosed head and neck cancers in the University Hospital, Kuala Lumpur.

A retrospective study of 1000 cases of microscopically diagnosed head and neck cancers in the University Hospital, Kuala Lumpur was done. Head and neck neoplasms comprise 7.1% of all tumours diagnosed in this Hospital and the commonest sites of involvement are the nasopharynx (29.1%), cervical lymph nodes (22.6%), oral cavity (10.2%), thyroid (8.2%) and skin (6.5%). Histologically, 87% of tumours are epithelial in nature. The results of this study show that nasopharyngeal carcinoma is commonest in Chinese males, while oral and laryngeal malignancies occur more frequently in Indians.

Asian People↗
PubMed1988

DNase I nick translation in situ on meiotic chromosomes of the mouse, Mus musculus.

DNase-I-sensitive sites have been located on the meiotic chromosomes of the mouse, Mus musculus, by the in situ DNase I nick-translation method. We find that: (1) of all the cell types studied, pachytene nuclei are the most sensitive to DNase I; (2) in diplotene the nicks occur preferentially in the vicinity of chiasmata; (3) the sex chromosomes are also sensitive to the enzyme despite their transcriptional quiescence; and (4) in the sex bivalent the nicks are primarily observed in the putative region of recombination. We conclude that, in addition to discriminating between the transcriptionally active and inactive states of chromatin, DNase I identifies recombination-specific chromatin changes in meiotic prophase.

Animals↗