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Biomedical subjects

R R Turnock

Publications and source records attributed to R R Turnock.

27 records · Page 2Linked to original sources

A study of mucosal gut immunity in infants who develop Hirschsprung's-associated enterocolitis.

The aim of this study was twofold. First, to establish quantitatively the distribution of the immunoglobulin-containing (plasma) cells, T and B lymphocytes in the lamina propria of the rectal mucosa of normal neonates and neonates with Hirschsprung's disease (HD). Second, to review the neonates with HD to determine any differences in these cell populations between those who subsequently developed Hirschsprung's enterocolitis (HEC) and those who did not. Two conclusions can be drawn from the results of our study of rectal mucosal immune defenses. First, neonates with HD have no deficiencies in these defenses when compared with normal neonates. Second, neonates with HD who subsequently develop HEC have no premorbid deficiency in these defenses. It was noted that the pan-T cell count in the infants who went on to develop HEC appeared to be increased, although this did not reach statistical significance. The use of fresh or frozen material would permit a more detailed analysis of the separate T cell subsets.

Child, Preschool↗

Primary anastomosis in apple-peel bowel syndrome.

During a 15-year period, 12 infants with apple-peel bowel were treated; the first 4 by initial enterostomy with delayed anastomosis and the remaining 8 by primary anastomosis. All four infants in the enterostomy group required parenteral nutrition, compared with only six of the eight who had a primary anastomosis. Seven of the eight infants treated by primary anastomosis were in hospital for less than 50 days, (however, the remaining child was an in-patient for over 2 years, but did suffer from short-bowel syndrome with only 17 cm of small intestine). In comparison, all four of the enterostomy group were hospitalised for between 70 and 175 days. All twelve patients survived.

Anastomosis, Surgical↗

Peno-scrotal transposition and the caudal regression syndrome.

Peno-scrotal transposition is a rare condition of variable severity, often associated with the Caudal Regression Syndrome. A case of incomplete peno-scrotal transposition, with a perineal anorectal duplication, vesico-ureteric reflux and thoracic hemivertebrae is presented. The literature is reviewed.

Abnormalities, Multiple↗

Comparison of postpyloromyotomy feeding regimens in infantile hypertrophic pyloric stenosis.

One hundred infants undergoing pyloromyotomy were studied prospectively to ascertain the optimum time at which to reintroduce feeds after operation. The babies were randomized to be fed after 4 or 18 h and were then assessed by monitoring the frequency of postoperative vomiting and the number of days taken to achieve full oral feeding. There was significantly more postoperative vomiting in the early group, while both groups required the same number of days to achieve full oral feeding. The conclusion reached was that a delay in the reintroduction of feeds until 18 h after pyloromyotomy is to be recommended.

Enteral Nutrition↗

Ureteral calculi in children: review of 50 consecutive cases.

Fifty children presenting with ureteral calculi over a twenty-year period were studied retrospectively. There were 35 boys and 15 girls, with a mean age of five and a half years. Nineteen patients had a urinary tract anomaly: 11 had an obstructed megaureter, and 8 had previously undergone urinary tract surgery. Forty-four children had infection stones and the remaining 6 oxalate calculi. Infected urine was found in 35; the infecting organism was a Proteus species in 23. Metabolic abnormalities were detected in 2 children. Operative removal of the stones was done in 39 patients, and in the remaining 11 patients the stones passed spontaneously. There were 6 recurrences, all within four years of initial presentation.

Adolescent↗

Baby walkers . . . time to take a stand?

Experience in our hospital and figures from the Home Accident Surveillance System indicate that the number of accidents involving baby walkers is increasing. Safety specifications issued by the British Standards Institution are rarely, if ever, met in full by manufacturers. Home accident prevention measures have been shown to be of limited benefit. We advocate more stringent implementation of safety features in the design of baby walkers.

Accidents, Home↗

Management of fetal urinary tract anomalies detected by prenatal ultrasonography.

Over a three and a half year period 32 babies were referred with a urinary tract anomaly diagnosed by prenatal ultrasound. This diagnosis was subsequently confirmed in 19 infants by postnatal assessment. Three of 13 infants in whom the original diagnosis was incorrect were subsequently found to have intra-abdominal pathology but no urological anomaly, while the other 10 had lesions in the urinary tract but not those suggested prenatally. Nineteen of the 29 babies with urological abnormalities were clinically normal at birth; 20 underwent surgery. There were three deaths; two from a combination of renal and pulmonary failure secondary to posterior urethral valves, and a third (in an infant who had normal renal function) from diaphragmatic hernia and cardiac anomalies. Prenatal diagnosis was thought to have been of benefit in six patients, of probable benefit in 16, and of no benefit in seven.

Humans↗