Time-domain measurements of cochlear nonlinearities using combination click stimuli.
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Animals↗
Biomedical subjects
R R Pfeiffer
Publications and source records attributed to R R Pfeiffer.
Distortion compensating, condenser-earphone driver for physiological studies.
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Acoustics↗
Cholesterol-solubilizing agents related to the gallstone problem.
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Animals↗
Anteroventral cochlear nucleus: wave forms of extracellularly recorded spike potentials.
Analysis of wave forms of spike potentials from neurons in the anteroventral cochlear nucleus indicates that the spikes are composed of three components. Two appear to be postsynaptic events, and one appears to be presynaptic and to be related to the calyces of Held found in that part of the nucleus.
Animals↗
Classification of response patterns of spike discharges for units in the cochlear nucleus: tone-burst stimulation.
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Animals↗
Spontaneous spike discharges from single units in the cochlear nucleus after destruction of the cochlea.
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Animals↗
On the sound pressure transformation by the head and auditory meatus of the cat.
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Acoustics↗
Stimulus coding in the cochlear nucleus.
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Animals↗
Structural features of vancomycin.
Recent analytical methods have advanced knowledge of the structure of vancomycin from a description of only several molecular fragments to a complete understanding of the intact molecule. The molecular weight is 1,448. The molecule consists of a seven-membered peptide chain that is formed by parts of three phenylglycine systems, two chlorinated tyrosine units, aspartic acid, and N-methylleucine. Two ether bonds and a carbon-carbon bond join the various substituents on the peptide chain into three large rings. A disaccharide, composed of glucose and vancosamine, is also present but is not part of the cyclic structure. Details of the vancomycin structure have been related to hydrogen bonding between the antibiotic and bacterial cell-wall precursors that have a D-alanyl-D-alanine carboxyl terminus; such bonding would provide a molecular basis for the cell-wall mode of action for vancomycin. With one carboxyl, two amino, and three phenolic groups, vancomycin undergoes a variety of ionic interactions in solutions of different pH and composition.
Binding Sites↗