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Biomedical subjects

R R Joseph

Publications and source records attributed to R R Joseph.

At least 37 records · Page 2Linked to original sources
PubMed1976

Increase in "Null" cells in acute lymphocytic leukemia in remission on long-term immunotherapy.

In an attempt to elucidate a possible mode of action of immunotherapy in ALL, we studied the mononuclear subpopulation in a group of patients with all in remission on long-term immunotherapy, a similar group on chemotherapy, and a group of normal individuals. Comparison of the three groups demonstrated a significant increase in the number and percentage of "null" cells in the immunotherapy group relative to the two others. Although the nature of these cells is unknown, circulating stem cells, "K" cells, or modified T, B, or monocytic cells are raised.

Adolescent↗
PubMed1975

Hemobilia and pancreatitis as complication of a percutaneous transhepatic cholangiogram.

Percutaneous transhepatic cholangiography (PTC) was performed on a 23-year-old male because of an atypical progression of hepatitis B antigen-negative hepatitis. No bile duct was entered and the procedure was uneventful. However, celiac angiography the day following PTC revealed abnormal liver vessels in the target area and the patient developed hemobilia and clinical pancreatitis, causing common bile duct obstruction. Symptomatology persisted until celiotomy 32 days after PTC. Clots were found obstructing the bile duct. This case is presented both because of the unusual complications of PTC and the unusual angiographic abnormalities. It is suggested that when there is a specific indication for the procedure either to differentiate cholestatic jaundice from extrahepatic jaundice or to localize a site of abstruction before surgical intervention.

Adult↗
PubMed1975

Clinical determination of methemalbumin.

We developed an assay for methemalbumin in biological fluids by using diethylaminoethyl-Sephadex ion-exchange chromatography to separate this protein from interfering components, including hemopexin, transferrin, hemoglobin, and haptoglobin/hemoglobin complex. Initial screening of the samples requires measurement of A280/A405 ratios of the peak tubes of the isolated albumin fraction. Values exceeding 30 indicate that methemalbumin is absent, and no further work is required. Values of less than 30 suggest that methemalbumin is present in the original sample, whereupon the presence and amount of methemalbumin can be ascertained by coloremetric assay for iron with use of ferrozine. Results may be expressed either in terms of micrograms of methemalbumin iron per gram of albumin or in milligrams of methemalbumin per liter. The reproducibility of the method is of the order of +/- 7% (SD). Normal persons have essentially no methemalbumin iron in their serum. Three individuals with hemorrhagic pancreatitis showed values of 65, 98, and 198 mug of methemalbumin Fe per gram of albumin.

Acute Disease↗