Biomedical subjects
R R Jones
Publications and source records attributed to R R Jones.
Is low-level lead pollution dangerous?
Explore the source record for details and available documents.
Cutaneous manifestations of paraproteinaemia. Part II.
Explore the source record for details and available documents.
Azathioprine therapy in the management of persistent erythema multiforme.
Explore the source record for details and available documents.
Dermatitis herpetiformis-like changes in cutaneous leucocytoclastic vasculitis with IgA deposition.
Explore the source record for details and available documents.
Pagetoid reticulosis and solitary mycosis fungoides. Distinct clinicopathological entities.
The two cases reported in this paper allow the differentiation of pagetoid reticulosis from solitary lesions of mycosis on the basis of clinical, histological ultrastructural, immunohistochemical and enzyme histochemical studies. The first patient presented with a slowly growing asymptomatic scaly plaque of 30 years duration. Histology of the lesion was typical of pagetoid reticulosis. Immunohistochemical studies showed that the abnormal cells present in the cutaneous infiltrate were not T lymphocytes and ultrastructural studies suggested these were of histocytic origin. The second patient presented with a poikilodermatous lesion present for 14 years with histology of plaque stage mycosis fungoides. Enzyme and immunohistochemistry showed the predominant T cell nature of the cutaneous infiltrate and electron microscopy showed numerous mycosis fungoides cells. In contrast to generalized forms of mycosis fungoides, no peripheral blood monocyte chemotactic defect was found in either case. Both lesions responded to radiotherapy.
IgA bullous pemphigoid: a distinct blistering disorder. Case report and review of the literature.
We report a patient with an eccrine carcinoma who developed localized blistering which clinically resembled pemphigoid, histologically showed subepidermal blistering with features of both dermatitis herpetiformis and bullous pemphigoid, responded to dapsone and exhibited linear IgA deposition on direct immunofluorescence. The nosological position of patients with linear IgA deposition and subepidermal blistering is not clear. A review of the literature reveals that in adults linear IgA deposition may occur in three separate situations: dermatitis herpetiformis, bullous pemphigoid and a third condition of which our case is an example which is best termed IgA bullous pemphigoid. This condition is distinguished from cases of dermatitis herpetiformis with linear IgA by the clinical features and the site of IgA deposition on immunoelectronmicroscopy. It is distinguished from cases of bullous pemphigoid with linear IgA by the absence of circulating IgG antibasement membrane zone antibody, the therapeutic response to dapsone and the frequent occurrence of circulating IgA antibasement membrane zone antibody. IgA bullous pemphigoid has not previously been reported with a carcinoma but the association lends further support to the concept that this eruption represents a variant of pemphigoid.
The cutaneous manifestations of paraproteinaemia. I.
Explore the source record for details and available documents.
C-reactive protein estimation in lupus erythematosus.
Explore the source record for details and available documents.
Behçet's syndrome with colonic involvement and arterial thrombosis.
Explore the source record for details and available documents.
Interrupted time-series analysis and its application to behavioral data.
This paper uses a question-and-answer format to present the technical aspects of interrupted time-series analysis (ITSA). Topics include the potential relevance of ITSA to behavioral researchers, serial dependency, time-series models, tests of significance, and sources of ITSA information.
Legg-Calvé-Perthes disease. Long-term evaluation of non-containment treatment.
Eighty hips with unilateral Legg-Calvé-Perthes disease were evaluated at an average follow-up of 22.4 years to determine the long-term results of treatment by a weight-relieving sling or harness. Results were good in sixty-four patients, fair in nine, and poor in seven. The patients with fair results had no clinical symptoms despite unacceptable roentgenograms. The hips that were most likely to have unsatisfactory results were those with Catterall Group-III or IV involvement and with onset at the age of six years or later, but of fifty-eight patients with Catterall Group-III or IV grades (eighteen of whom were six years old or older), forty-two had good results. Catterall's classification could not be accurately applied for an average of 8.1 months after the onset of disease. Identification of so-called head-at-risk signs, while it was important, appeared to add little to the Catterall grading as a prognostic index or therapeutic guide. Thirty-nine hips were identified as being at risk, including six of the seven with poor results and all of the nine hips with fair results.
Complement abnormalities in diffuse plane xanthomatosis with paraproteinaemia.
Paraproteinaemia may be associated with xanthomatous skin deposits and these can arise in the absence of elevated lipid levels. Two cases of benign monoclonal gammopathy with diffuse plane xanthomatosis are reported. Case 1 exhibited hypolipidaemia and a functional deficiency of C1 esterase inhibitor. Case 2 showed a normal lipoprotein profile, abnormal platelet aggregation, and a cutaneous vasculitis with evidence of complement consumption via the classical pathway. The significance of these abnormalities is discussed.
Warfarin skin necrosis. The role of factor VII.
Necrosis of cutaneous and subcutaneous tissue is a rare complication of therapy of with oral anticoagulants, and is related to the use of loading-dose regimes. Three cases are reported, and demonstrate that the principal histopathological feature is thrombosis within the subcutaneous vasculature. The effect of large doses of anticoagulant on the levels of the vitamin K dependent clotting factors provides a satisfactory model for the temporal sequence of events in this syndrome. The occurrence of intravascular thrombosis with low or absent levels of Factor VII indicates that the intrinsic clotting system is of primary importance in venous thrombosis. This complication of anticoagulant therapy is not seen if loading-dose regimes are avoided.
Epidermolysis bullosa. Report of a family and discussion of the dominant dystrophic types.
Explore the source record for details and available documents.
Effects of serial dependency on the agreement between visual and statistical inference.
Comparisons between visual and time-series inferences from behavioral data show that serial dependency in scores is likely to disrupt agreement between the two methods of analysis. If researchers follow an earlier recommendation that time-series analysis be used to supplement or confirm visual analysis, this study's findings suggest that the two methods will disagree most often when the data contain high levels of autocorrelation and when reliable behavorial changes are indicated by time-series analysis.
Time-series analysis in operant research.
A time-series method is presented, nontechnically, for analysis of data generated in individual-subject operant studies, and is recommended as a supplement to visual analysis of behavior change in reversal or multiple-baseline experiments. The method can be used to identify three kinds of statistically significant behavior change: (a) changes in score levels from one experimental phase to another, (b) reliable upward or downward trends in scores, and (c) changes in trends between phases. The detection of, and reliance on, serial dependency (autocorrelation among temporally adjacent scores) in individual-subject behavioral scores is emphasized. Examples of published data from the operant literature are used to illustrate the time-series method.