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Biomedical subjects

R R Cook

Publications and source records attributed to R R Cook.

81 records · Page 5Linked to original sources
PubMed1982

Case-control study of brain tumor deaths among employees at a chemical manufacturing plant.

Recent studies have reported an increased risk of death from primary intracranial neoplasms among employees in the petrochemical industry. One of them, a NIOSH/OSHA county-based case-control study, suggested a twofold risk for having ever been employed at the Texas Division of Dow Chemical U.S.A. Using the case-control approach, we compared 24 brain tumor cases among employees at this large, diverse chemical plant in Texas with two sets of age-, race-, and sex-matched controls to determine if a risk could be associated with job assignment in a particular process area, with presumptive exposure to a major process chemical, or with a number of other occupationally related and unrelated variables. Results implicated no specific area or chemical. The only significant findings were an elevated odds for being hired prior to 1950 and a negative correlation with employment greater than 10 years. Further, preliminary calculations of expected deaths from primary intracranial neoplasms among the employee cohort suggested there was no excessive risk.

Adult↗
PubMed1980

Mortality experience of employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

This study describes the mortality experience of a cohort of 61 males involved in a 1964 chloracne incident. Presumably as a result of skin absorption of the process contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), 49 of these trichlorophenol production workers developed the skin condition. Within the limitations posed by cohort size and length of follow-up, TCDD does not appear to have adversely affected mortality experience. Overall, four deaths occurred and 7.8 were expected. Of these, one death was due to cardiovascular disease (3.8 expected) and three deaths were attributed to cancer (1.6 expected). None of the findings were statistically significant at alpha = 0.05. Further follow-up is contemplated.

Acne Vulgaris↗
PubMedDate not supplied

A cross-sectional study of ethylene glycol monomethyl ether process employees.

Human exposures to ethylene glycol monomethyl ether have been associated with hematological and neurological abnormalities. Recent animal toxicology studies have also reported testicular atrophy. To determine whether employees potentially exposed to ethylene glycol monomethyl ether during manufacturing and packaging had a higher prevalence of anemia, leukopenia, or sterility than an in-plant comparison group, a cross-sectional study was conducted at the Michigan Division of Dow Chemical U.S.A. Blood samples on 65 of 97 potentially exposed and control white males, and semen samples from a subset of 15 were analyzed. With the possible exception of smaller testicular size, no gross abnormalities or clinically meaningful differences in hematological or fertility indices were noted. Results of regression modeling suggested that white blood cells and hemoglobin might be decreased at higher exposure levels.

Adult↗
PubMedDate not supplied

Mortality experience of employees with occupational exposure to DBCP.

Concern about the carcinogenic potential of 1,2-dibromo-3-chloropropane(DBCP) has arisen recently, focusing on six organ sites: stomach, liver, kidney, lung, testes, and skin. To examine the mortality experience of persons potentially exposed, a cohort of 550 employees involved in production and formulation from 1957 to 1976 was defined. A total of 35 deaths was observed through 1979 (39.2 expected). No statistically significant excess was observed for any cause of death. No cancer deaths were noted for five of the hypothesized sites. For the lung cancer category, five deaths were observed (2.7 expected, P greater than .135), two of which occurred in a subgroup directly exposed for at least 1 yr (0.5 expected, P greater than .077). Aside from arsenicals exposure, potential confounding resulting from smoking or multiple chemical exposures could not be evaluated.

Antinematodal Agents↗