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Biomedical subjects

R R Burton

Publications and source records attributed to R R Burton.

At least 37 records · Page 2Linked to original sources
PubMed1992

Physiologic validation of a short-arm centrifuge for space application.

A short-arm centrifuge (SAC) of 5-6 ft (1.5-1.8 m) radius may be useful in space to measure tolerances to acceleration (G) and to stimulate the cardiovascular system, thereby reducing cardiovascular decompensation that occurs in weightlessness. Relaxed rapid (1G/s onset rate, ROR) and gradual (0.1 G/s onset rate, GOR) G tolerances were measured on seven men using a 5-ft (1.5 m) radius centrifuge and compared with their G tolerances obtained on the 20-ft (6.1 m) radius human-use centrifuge at the Armstrong Laboratory, Brooks AFB, TX. Since the subjects were required to flex their legs to assume a squatting position on the SAC, a similar position was used on the 20 ft (6.1 m) centrifuge called feet up (FU), and compared with normal-seated +Gz tolerances (controls). The subjects tolerated the SAC exposures without any problems. ROR and GOR tolerances were as follows: control, 3.6 G and 4.2 G; FU, 4.5 G and 5.6 G; and SAC, 4.6 G and 6.4 G. We concluded that a 5-ft radius centrifuge can be used to measure G tolerances. The increases in the SAC GOR tolerances over ROR tolerances indicate that the baroreceptors were stimulated by the G, and the SAC exposure would be useful in preventing cardiovascular decompensation in microgravity.

Adult↗
PubMed1991

Panel on deliberate G-induced loss of consciousness: introduction.

Over the last decade, G-induced loss of consciousness (G-LOC) has been recognized as a significant operational problem for pilots of high performance aircraft in both the U.S. Air Force and U.S. Navy. Consequently, government laboratories have initiated research studies to learn more about the G-LOC phenomenon in an attempt to reduce its hazards. Many of these studies require the occurrence of LOC during their conduct. For this reason, animal models have been developed to use in these studies. However, even though sophisticated animal models such as baboons can be taught to perform tasks before and after G-LOC has occurred, these models have deficiencies that can be overcome only by the use of human volunteers who willingly submit to G-LOC studies on the centrifuge. Such human G-LOC studies began in World War II and continue today. These studies are presently conducted without guidelines regarding subject selection, numbers of G-LOCs allowed per subject per unit time, restraint systems, or specific medical examinations required before, during, and after each episode of LOC, or after each completed study. This panel will discuss what is known about the pathophysiology of G-LOC, the limitations of animal models in these types of studies, the possible medical and psychological sequelae, and the legal implications of conducting deliberate G-LOC research. We hope that the information developed by this panel will be useful to laboratory human-use review committees in determining the requirements and the nature of guidelines for conducting such studies.

Aerospace Medicine↗
PubMed1990

Physiologic correlates of protection afforded by anti-G suits.

A new uniform-pressure pneumatic anti-G suit (UPS) was compared with the standard CSU-13B/P anti-G suit, using measurements of: blood lactate, heart rate changes, and segmented lower-body blood pooling (by impedance plethysmography). Subjects were exposed to a series of gradual-onset-rate (GOR) runs (0.1 G.s-1), rapid-onset-rate (ROR) runs (6 G.s-1), and simulated aerial combat maneuvers (SACM) on the USAF School of Aerospace Medicine human-use centrifuge. All measured parameters and subjective reports indicated that increased protection was afforded by the UPS. The impedance plethysmography measurements indicated that prevention of blood pooling in all lower-body segments is the predominant mechanism whereby uniform pressure permits significantly longer times-to-fatigue during SACMs.

Adult↗
PubMed1988

G-induced loss of consciousness: definition, history, current status.

G-induced loss of consciousness (G-LOC) is defined as "a state of altered perception wherein (one's) awareness of reality is absent as a result of sudden, critical reduction of cerebral blood circulation caused by increased G force." This phenomenon was first identified in Great Britain in World War I (circa 1918-1919) as "fainting in the air." In the United States G-LOC was first encountered in 1922 during the Pulitzer Trophy Air Race. Although recognized during World War II as an operational hazard for fighter aircraft, the invention of the pneumatic anti-G suit reduced concern about G-LOC at that time. A 1984 survey of pilots of high performance aircraft has shown G-LOC to be an operational problem--probably one that has caused aircraft mishaps for several years. The concern of this panel was to focus on various approaches in reducing the G-LOC hazard.

Cognition Disorders↗
PubMed1988

Optimum sampling times for maximum blood lactate levels after exposures to sustained +Gz.

Six male subjects wearing anti-G suits were exposed to +4.5 Gz and +4.5-7 Gz simulated aerial combat maneuvers (SACM), sustained until terminated because of fatigue. Before and after each G exposure, venous blood was withdrawn (using the finger-prick method) and analyzed for lactate concentration. Five samples were taken serially, at 1, 3, 6, 10, and 20 min after each G exposure to determine the maximum (peak) level of blood lactate. Individual lactate levels varied, with peaks at 1, 3, and 6 min; however, group levels were maximum at 3 min after the G exposure. Maximum lactate levels (mean +/- S.D.) of 27.8 +/- 11.3 mg% and 42.7 +/- 19.4 mg% were found for the 4.5-G and SACM exposures, respectively. Lactate recoveries were a simple exponential function, with a half life of approximately 10 min. The relationship between these data, following G exposure, and those measured after aerobic physical activities, is discussed.

Gravitation↗
PubMed1988

Anti-G suit inflation rate requirements.

Relaxed +Gz rapid-onset tolerances were measured on the human-use centrifuge at the USAF School of Aerospace Medicine, using male research subjects with and without inflated anti-G suits. Tolerance at 6 G.s-1 onset rates were 0.2-0.3 G lower than those measured with 1 G.s-1 onset rates, thus suggesting the existence of another relaxed G tolerance measurement called very high onset G. Baroceptor effect was considered the reason for this difference. Delays of a mean of 3.3 s in inflating the anti-G suit did not change relaxed G tolerances at 6 G.s-1 onset rates; however, with a 4.2-s mean delay, light-loss tolerance criteria occurred sooner during the G exposure. Tolerances to 7 G with 6 G.s-1 onset rates, during which the subjects had to perform the anti-G straining maneuver (AGSM), required a mean delay of 2.8 s in six subjects before a noticeable change in light-loss criteria occurred--a mean delay of 2.0 s resulted in no change in light-loss criteria from zero delay control inflation rates. These results clearly indicate that the inflation of the anti-G suit can be delayed by at least 1 s without compromising anti-G suit protection.

Acceleration↗
PubMed1987

Induction and prevention of acceleration atelectasis.

Acceleration atelectasis is the absorptional collapse of alveoli in the dependent lung due to increased accelerative forces. It is exacerbated by breathing 100% oxygen and, during +Gz exposure, by the use of an anti-G suit. Experiments were conducted on 12 subjects using simulated aerial combat maneuvers (SACM) with G profiles having peak exposures of either 4.5 G or 9 G. Decreases in vital capacity (VC) measurements were used as quantification of atelectasis, two types of reduction being identified and described. Labile reductions in VC were readily restored by a deep breath or cough. Such reduction approximated 28% following the 4.5-G SACM and 25% following the 9-G SACM. More persistent (so called) stable reductions were of lesser degree, values of -20% being seen following both 9 G and 4.5 G maneuvers. Acceleration atelectasis causes symptoms of chest pain, coughing, and shortness of breath. Subjective ratings of the severity of these symptoms were obtained from the subjects, and these were much greater following the 4.5-G SACM exposures than after the 9-G runs. Acceleration atelectasis was reduced by dilution of the inspired oxygen concentration by argon and nitrogen (evaluated at 95, 82.5, 70, 50, and 20% oxygen); the addition of unassisted positive pressure at 30 mm Hg (4 kPa) to the breathing mask; or the performance of the anti-G straining maneuver (AGSM).

Acceleration↗
PubMed1987

+Gz-induced loss of consciousness: a case for training exposure to unconsciousness.

+Gz-induced loss of consciousness (G-LOC) continues to be a threat to aircrew flying high-performance fighter aircraft. All avenues to prevent G-LOC, and to reduce the resulting incapacitation should G-LOC occur, must be explored. Research has begun to accurately quantify all aspects of the G-LOC phenomenon. The emerging pattern from this research indicates that, theoretically, G-LOC incapacitation could be significantly reduced. Comparison of G-LOC with LOC induced by acute arrest of cerebral circulation reveals that the G-LOC incapacitation could be reduced by as much as 17 s. Results also indicate that the relative incapacitation period (confusion and disorientation) following unconsciousness could be reduced by at least 9 s for an individual who has previously experienced G-LOC. This suggests that exposure to G-LOC during centrifuge training could provide this orientation to G-LOC and potentially reduce the incapacitation period should it occur inflight. This exposure may be likened to the current altitude-hypoxia training requirement for aircrew. Experience to date supports the contention that such training may be accomplished with an acceptable safety margin.

Adolescent↗
PubMed1987

+Gz-induced loss of consciousness and aircraft recovery.

Aircrew incapacitation resulting from very high onset sustained +Gz stress has resulted in significant losses of aircraft and aircrew. Enhanced protection and training toward prevention of +Gz-induced loss of consciousness (G-LOC) will continue to be vital. Techniques for reduction of the time of incapacitation, should G-LOC occur, must also be explored and developed. Current capability of aircraft autorecovery as demonstrated by the Advanced Fighter Technology Integration F-16 (AFTI/F-16) promises to enhance safety from the acute incapacitation resulting from G-LOC (and spatial disorientation). Physiologic monitoring for determining G-LOC has certain advantages especially in the aerial combat arena. The optimum physiologic monitoring technique would be direct determination of failure of brain cell function at the cellular or subcellular level. Complete investigation of G-LOC is necessary to understand the phenomenon and to develop methods for enhancing recognition and recovery. This paper discusses aircraft autorecovery technology and potential methods for physiologic monitoring of G-LOC. Integration of physiologic monitoring techniques into aircraft autorecovery systems requires a broad approach for optimal development.

Aerospace Medicine↗
PubMed1987

Characterization of the resulting incapacitation following unexpected +Gz-induced loss of consciousness.

+Gz-induced loss of consciousness (G-LOC) results in incapacitation which can be characterized by the unconscious period (absolute incapacitation) and a subsequent period of confusion/disorientation (relative incapacitation). The sum of the absolute and relative incapacitation periods represents the total incapacitation period and may be equated to the overall length of time a pilot would be in uncontrolled flight should G-LOC occur. Reviewing the centrifuge induced G-LOC episodes in 55 subjects allowed a detailed description of G-LOC. The absolute incapacitation period was 16.6 s with the subsequent relative incapacitation being 14.5 s resulting in an overall total incapacitation of 31 s. The G-LOC incapacitation was dependent on the rate of onset of the +Gz-stress and the +Gz level where G-LOC occurred. G-LOC episodes could be subdivided into 2 separate types: Type I being shorter unconsciousness episodes without convulsive movements, and Type II being longer unconsciousness with more frequently associated dream states and convulsive type movements. This detailed description of G-LOC allows a more complete understanding of the phenomenon and establishes the basis for research toward decreasing the resulting incapacitation from G-LOC. Minimizing G-LOC incapacitation and enhancing recovery should enhance safety in the aviation environment of the high-performance-fighter aircraft pilot.

Acceleration↗
PubMed1987

Anaerobic energetics of the simulated aerial combat maneuver (SACM).

The role of anaerobic metabolism in +Gz duration tolerance was measured using venous blood lactate concentrations before G exposure and after subjects had been fatigued from exposure to one of several levels of G: low (4.5 G) sustained G (LSG); high (7-9 G) sustained G (HSG); and simulated aerial combat maneuver (SACM) of 4.5/7 G levels. A mean +/- S.E. blood lactate of six subjects fatigued from LSG was 29.8 +/- 4.0 mg%. Four subjects fatigued from HSG had blood lactates of 42.4 +/- 3.2 mg%, and six had blood lactates of 46.7 +/- 7.2 mg% from the SACM. Blood lactates appeared to correlate directly (on a group basis) with maximum heart rates found during G exposures. Six subjects exposed to 8 or 9 G for 10 s or less demonstrated an anaerobic alactate capacity. These G findings were related to fatigue produced with isometric muscle contraction in physiologic studies conducted at 1 G. We concluded that anaerobic metabolism and isometric exercise physiology are directly related to duration tolerances of fatigue at all levels of +Gz.

Aerospace Medicine↗
PubMed1986

Hemodynamics of miniature swine during +Gz stress with and without anti-G support.

Nine unanesthetized, chronically instrumented, female miniature swine (MS) (avg wt, 39.7 kg) were exposed to head-to-tail inertial load (+Gz) levels of +3, +5, and +7 Gz for 60 s, with and without anti-G-suit inflation. Venous flow (VF) was measured by an electromagnetic flow sensor around the inferior thoracic vena cava at the diaphragm. Central venous pressure (CVP), abdominal venous pressure (AVP), eye-level blood pressure (ELBP), and esophageal pressure (EP) were also measured before, during, and after +Gz. There was a progressive significant decrease from control of both ELBP (P less than 0.001) and VF (P less than 0.05) during the three +Gz exposures, both with and without G-suit inflation. Without G-suit inflation, most of the MS were unable to tolerate +5 and +7 Gz. Although VF was significantly (P less than 0.02) improved by G-suit inflation during +Gz there was no significant difference in VF between the three +Gz levels, with or without G-suit inflation. The MS does a spontaneous straining maneuver (cyclic Valsalva) during +Gz with G-suit support. Using EP as a trigger, the data were grouped as strain or no strain (relaxation). A continuous AVP-to-CVP gradient existed during G-suit inflation, which increased dramatically during no strain with increasing +Gz, and was associated with an increase in VF. Thus, the majority of VF occurred during relaxation between strains, even though relaxation time was shortened as +Gz increased. Although ELBP is obviously dependent on cardiac output and venous return, the progressive reduction in ELBP with increased +Gz loads was not significantly related to changes in VF at the diaphragm which was maintained, although at a reduced rate, by the AVP-to-CVP gradient during G-suit inflation.

Acceleration↗