Biomedical subjects

R R Bradley

Publications and source records attributed to R R Bradley.

4 recordsLinked to original sources

PubMed1999

Hematopoietic effect of Radix angelicae sinensis in a hemodialysis patient.

The primary cause of anemia of chronic renal failure (CRF) is insufficient production of erythropoietin by the diseased kidneys. Although most patients receiving hemodialysis (HD) respond to recombinant human erythropoietin (rHuEPO) treatment, 4% prove to be rHuEPO resistant. The patient presented in this case study suffered from anemia of CRF that was resistant to rHuEPO therapy. He experienced marked improvement in the anemia after self-initiating regular consumption of the Chinese herb Dang qui (botanical name: Radix angelicae sinensis). The significant hematologic amelioration occurred in the face of a major decrease in the amount of rHuEPO administered. The causes and mechanisms of inadequate response to rHuEPO, as well as the possible beneficial hematopoietic effects of this herbal preparation, are discussed.

Anemia↗

PubMed1997

Vulvar melanoma in childhood.

BACKGROUND: Malignant melanoma is rarely diagnosed during childhood. Approximately 2% of malignant melanomas occur in patients younger than 20 years, with 0.3% to 0.5% of cases occurring in prepubescent children. In adult females malignant melanoma of the vulva and vagina is 100-fold less common than malignant melanoma of nongenital skin. Malignant melanoma of the vulva occurring in a child has been reported once before. OBSERVATIONS: We report 2 cases of childhood vulvar malignant melanoma presenting in preteenage girls. In both cases, the lesions were asymptomatic enlarging hyperpigmented macules on the labium minus. In addition to features diagnostic of malignant melanoma, histological evidence of lichen sclerosus et atrophicus was identified in both lesions. Local excision with conservative margins was the treatment modality of choice in both cases, with good preservation of anatomic structure and function. CONCLUSIONS: This report is of 2 cases of vulvar melanoma in childhood, a rare, yet potentially devastating, presentation of melanoma. Biopsies on suspicious pigmented lesions on the vulva of prepubescent children should be done to rule out malignant change.

Child↗

PubMed1987

Familial anetoderma.

Two families with anetoderma are described. Unlike previous reports of familial anetoderma, the disease process seemed to be limited to the skin, and there were no associated ocular, gastrointestinal, or orthopedic anomalies in the affected patients or in any other family members. Although infrequently reported, anetoderma may occur in families, and patients must be examined for associated systemic abnormalities for a thorough assessment of their skin disorder.

Adult↗

PubMed1980

Amelanotic lentigo maligna.

A 68-year-old woman had a pigmented lentigo maligna lesion excised from her left arm. During a seven-year follow-up period, the excision site gradually evolved into a hypopigmented macule with irregular areas of mild erythema. The clinical impression was neurodermatitis, but a biopsy specimen revealed lentigo maligna without melanin pigmentation. To our knowledge, this is the first case of amelanotic lentigo maligna reported in the English literature in which the clinical presentation was dermatitis-like. Our experience suggests that biopsy should be done on all clinically changing sites of treated lentigo maligna, whether the changes are pigmented or not.

Aged↗