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Biomedical subjects

R Putelat

Publications and source records attributed to R Putelat.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Association of Basedow's disease and autoimmune thrombopenic purpura. No effect of hyperthyroidism on antiplatelet autoimmunity].

The association between Graves' disease and autoimmune thrombocytopenic purpura is rare and yet more frequent than would be expected from a mere coincidence. The existence of an immunological disorder common to Graves' disease and autoimmune thrombocytopenic purpura and/or a direct responsibility of hyperthyroidism in the genesis of immunological disturbances resulting in autoimmune thrombocytopenic purpura are hypotheses put forward to try and explain why these two pathologies are associated. We report two cases in which the antiplatelet autoimmunity developed independently of the thyroid functional disorder, making it unlikely that hyperthyroidism played a direct role in the occurrence of the immunological disorders responsible for the autoimmune thrombocytopenic purpura. The physiopathology responsible for the Graves' disease-autoimmune thrombocytopenic purpura association remains imperfectly known. The existence of an immunological pathogenetic mechanism underlying both diseases seems to be likely; it probably acts through an antigenic determinant that is common to thyroid cells and platelets.

Adult↗
PubMedDate not supplied

[Endocrine abnormalities in HIV infections].

The finding of endocrine gland lesions at pathological examination in AIDS and reports of several cases of endocrine disease in patients with this syndrome have prompted us to study endocrine functions in 63 patients (51 men, 12 women) with HIV-1 infection. According to the Center for Disease Control (CDC) classification system, 13 of these patients were stage CDC II, 27 stage CDC III and 23 stage CDC IV. We explored the adrenocortical function (ACTH, immediate tetracosactrin test) and the thyroid function (free T3 and T4 levels, TRH on TSH test) in all 63 patients. The hypothalamic-pituitary-gonadal axis (testosterone levels, LHRH test) and prolactin secretion (THR test) were explored in the 51 men. The results obtained showed early peripheral testicular insufficiency at stage CDC II and early pituitary gland abnormalities with hypersecretion of ACTH and prolactin also at stage CDC II. On the other hand, adrenocortical and pituitary abnormalities were not frequently found. The physiopathology of the endocrine abnormalities observed in HIV-1-infected patients remains unclear, but one may suspect that it involves interleukin-1 since this protein factor has recently been shown to stimulate the corticotropin-releasing hormone secretion and to act directly on the glycoprotein capsule of the virus (gp 120) whose structure is similar to that of some neurohormones.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Trouble of liver function in polymyalgia rheumatica (author's transl)].

The possible existence of liver function disease such as cholestasis during temporal arteritis or polymyalgia rheumatica has been recently discovered. Two cases are reported of cholestasis without jaundice during polymyalgia rheumatica. The altérations most frequently observed are the elevation of the alcalin phosphatases, 5' nucleotidases, gamma G.T. and the retention of BSP. The syndrome disappears by treatment as well as the rheumatologic disease. It seems to be interesting to diagnose polymyalgia rheumatica through this trouble of liver funcion.

Cholestasis, Intrahepatic↗
PubMedDate not supplied

[Prognostic evolution of Graves' disease. Surgical treatment (author's transl)].

We report 80 cases of Graves' disease with goiter and homogeneous scintiscan. All the patients underwent surgery after treatment of hyperthyroidism by ATD then by iodine : bilateral subtotal lobectomy was performed in 89 % of cases. The patients have been followed up for 1 to 10 years after surgery, the actuarial rate of euthyroidism is stable at 77 % from the 3rd to the 10th year on. In the same way, 16 % of hypothyroidism and 9 % of recurrent hyperthyroidism do not change from respectively the first and the third year to the tenth after surgery. No correlation has been found between their appearance and the various clinical and biological parameters which has been studied.

Adult↗