Biomedical subjects
Publications and source records attributed to R Puri.
Recordings have been made from cold-receptive neurons in trigeminal nucleus caudalis to define the lower receptive field temperatures at which the neurons become silent. Most cells were found to become silent at 0 degrees C, but a few were still active at skin temperatures of -5 degrees C.
A case of intimal tearing of the axillary artery in association with a close fracture of the neck of the humerus is described. This is a rare injury and illustrates that vascular damage should never be assumed to be due to spasm. Exploration must be carried out because a mechanical vascular occlusion is most likely.
The pathogenesis of slipped upper femoral epiphysis is unknown but the condition has been linked with various endocrine disorders. Nine patients with slipped epiphyses in association with primary juvenile hypothyroidism are presented. In all patients, slipping occurred or symptoms developed in the affected hip before the hypothyroidism was diagnosed. A generalised pathology was suggested by the absence of trauma (8 patients), by bilateral slipping (6 patients), and by obesity and short stature in all patients. All cases had delayed skeletal maturation and characteristic metaphysial changes were seen on their radiographs. The clinical diagnosis of juvenile hypothyroidism can be difficult but it merits consideration in patients who have a slipped upper femoral epiphysis in association with short stature, obesity, delay in skeletal maturity, or any one of these.
Valgus deformity of the hindfoot can occur at the subtalar joint, the ankle joint, or at both sites. In children suffering from spina bifida, the ankle is often the main site of deformity. Thirty-five ankles with valgus deformity of the hindfoot were studied in 23 children with spina bifida. A radiological triad was observed in all patients: shortening of the fibula, lateral wedging of the distal tibial epiphysis, and lateral tilt of the talus at the ankle mortise . There was a definite correlation between the severity of wedging and the degree of talar tilt, and a fair correlation between the severity of wedging and the extent of fibular shortening. The results of operation in 12 feet are presented. It is concluded that any operations performed below the ankle on these patients (subtalar fusion or triple arthrodesis) is unlikely to succeed; the deformity needs to be corrected above the ankle (by epiphysiodesis or supramalleolar osteotomy). Radiological assessment of the ankle by taking weight-bearing films in the anteroposterior plane is essential to determine the true extent of the deformity before undertaking any operation.
The clinicopathological features of an unusual granular cell myoblastoma involving the fifth cranial nerve are presented. Evidence incriminating the Schwann cell as the source of the granular cell is also discussed.
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OBJECTIVE: To perform a comparative evaluation of various endoscopic techniques in the diagnosis of upper gastrointestinal tract malignancies. STUDY DESIGN: Thirty cases of suspected malignancy involving the upper gastrointestinal tract were studied. In all 30 cases, four endoscopic cytology techniques (brushing before biopsy, brushing after biopsy, fine needle aspiration cytology [FNAC] and suction cytology) were evaluated and correlated with histology by forceps biopsy. All the cytologic techniques were used and forceps biopsy carried out in a single sitting, but the forceps biopsy was repeated in 4 of 30 cases. RESULTS: The respective positive yields of brushing before biopsy, brushing after biopsy, FNAC, suction cytology and forceps biopsy were 80.0%, 86.6%, 83.3%, 76.6% and 90.0%. When two cytologic techniques were combined, 100% accuracy was obtained by brushing after biopsy and FNAC and brushing before biopsy and suction cytology. CONCLUSION: Brushing cytology is a sensitive diagnostic test, and the combined use of biopsy and brushing offers the highest probability of identifying malignancy.
Histological and ultrastructural changes were investigated in lung, liver, and heart of mice given interleukin-2 (IL-2), either alone or in combination with other cytokines. IL-2 induced a vascular leak syndrome (VLS) of a moderate degree with infiltration of lymphoid cells, moderate endothelial damage, mild hepatic parenchymal damage, and minimal myocardial alterations. Interferon-alpha (IFN-alpha) produced infiltration mainly of monocytes/macrophages in liver and heart; endothelial cell damage was absent in lung and heart and minimal in liver. Interleukin-1 alpha (IL-1 alpha) caused an increased number of neutrophils in liver and lung; VLS and parenchymal cell and endothelial damage were not found. The VLS and the cellular damage caused by the combination of IL-2 and IFN were much more severe than those produced by IL-2 alone. In animals treated with IL-2, IFN-alpha, and IL-1 alpha, VLS was minimal and parenchymal and endothelial cell damage were less severe than after IL-2 alone or IL-2 plus IFN-alpha. Taken together, these observations show that IL-1 alpha reduces ultrastructural changes produced by IL-2 and IFN-alpha. This reduction may be clinically useful in the treatment of neoplasms.
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