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Biomedical subjects

R Poirier

Publications and source records attributed to R Poirier.

At least 55 records · Page 3Linked to original sources
PubMed1980

Insulin dependent diabetes: a comparison of families with single and multiple affected siblings.

Families (n = 14) with more than 1 sibling with insulin dependent diabetes were matched with families of similar size and age distribution containing only 1 affected child. The distribution of HLA haplotypes, age of onset of disease, and seasonal onset of disease were compared in the two groups. The data are not consistent with the hypothesis of a single autosomal recessive gene linked to the HLA region. The data do not permit a choice between other current hypotheses although they are compatible with the theory of 2 genes linked to the HLA region, acting additively, and requiring interaction either with environmental factors or other disease susceptibility genes. Diabetic children in the multiplex and simplex families did not differ in the month of onset of symptoms nor in the age at diagnosis although three multiplex pedigrees in which diabetes developed in all affected children before the age of 6 years were identified.

Adolescent↗
PubMed1980

[Study of the regional distribution of inspired gas with radioactive tracers (author's transl)].

Two different techniques are utilized: aerosol with 198Au particles (size 0.5-15 micron) and different gaz mixtures (air; O2 20% + He 80+; O2 60% + N2 40%; O2 60% + He 40%) with 133Xe and registration of the regional distribution along a wash-in (upper, middle and basal) of every lung (gamma camer, computer, Polaroid photographs, scans), performed in three groups of subjects (normal: 5, bronchogenic carcinoma: 11 and chronic bronchitis: 5). Modifications of the airway distribution and blood gas data according to the technical approach (particularly, variations of densities and viscosities) are compared with results in normal subjects.

Adult↗
PubMed1980

[Contribution to the study of the phagocytosing ability of broncho-alveolar macrophages in smokers and non-smokers (author's transl)].

Broncho-alveolar macrophages were obtained by bronchial washing from 20 pairs of matched smokers and non-smokers. The following parameters were studied: phagocytosing ability of macrophages on silica in cell culture in the presence or absence of cotinin, a biocompound of nicotin; migration inhibitory factor (MIF), and power and level of alpha 1-antitrypsin in sera of patients. The results are reported as a function of absolute number of macrophages obtained, their viability, the amount of cigarettes smoked, and the action of cotinin. MIF was stronger in the smokers. There was no difference between the groups as far as power and level of alpha 1-antitrypsin are concerned. Cotinin provokes important lesions in the macrophages. The phagocytic power was not significantly different in smokers and non smokers, but the results were better in non-smokers.

Aged↗
PubMed1980

[Dermatoglyphics of subjects with bronchial cancers].

Every high smokers are not able to make a lung carcinoma, on the over hand nonsmokers can be able to develop a bronchial carcinoma. It is possible that genetic factors can be involved in the occurrence of this carcinoma. Dermatoglyphic studies are one of the technics to appreciate this problem. The study was done upon 37 bronchial carcinoma and 51 lung diseases (European origin, only man, same age). There are some big differences upon: --The Cummins index: the right index as well as the left are higher in bronchial carcinoma than in controls, but it is significative only for the right one (p less than 0,05) (28,89 +/- 3,7 to 26,88 +/- 4,55). --The frequency of the ten fingerprints: the differences between lung carcinoma and controls are highly significative (p less than 0,01) for the whorls (22,7 to 34,9) and slightly significative (p less than 0,05) for the ulna loops (65,4 to 57,4), the other fingerprints (arch, radial loops) are quite the same in the two groups. The studies upon the other figures (TFRC and the position of the axial tri-radius) do not show any differences. It seems to us that the dermatoglyphic studies of men with bronchial carcinoma differ from controls (hospitalized for lung diseases). These population have the same dermatoglyphic structure than a control population from blood donors of Marseilles. The dermatoglyphic studies can be an aid to identify high risk people.

Aged↗
PubMed1979

Epidemiologic survey of juvenile-onset diabetes in Montreal.

Active search of hospital records was used to survey insulin-dependent juvenile-onset diabetics younger than 17 years resident in General Montreal at the time of onset of symptoms during a seven-year period (1971-1977). A mean annual incidence of 8.8/100,000 was found with variation from year to year (5.8 to 10.3). Eighty percent were five years of age or more at time of diagnosis, and the increase with advancing age was similar to that seen in other studies including the somewhat earlier increase in incidence among females. Seasonal peaks were noted in some but not all years and were more marked in years of high incidence and among males. More cases occurred in areas of high socioeconomic level as measured by average family income. The estimated incidence among siblings of diabetics is 15 times the incidence in the general population. Ten percent of diabetics have a first degree relative who is insulin dependent.

Adolescent↗
PubMed1979

[Systematic evaluation of 8 arginine vasopressin and neurophysins plasma levels in 10 patients with oat cells carcinoma of the lung (author's transl)].

Plasma AVP level, neurophysins and osmolality have been measured in 10 patients with oat cell carcinoma of the lung but without any biological signs of syndrome of inappropriate secretion of ADH (SIADH), before and 15 mn after an intravenous injection of Ethanol. No statistically significant difference was noted in the AVP, neurophysins and osmolality values between 10 patients with asymptomatic oat cell carcinoma and control population (10 normal volunteers, 12 patients with non neoplasic lung pathology and 10 patients with different lung carcinoma). We concluded that AVP and neurophysins cannot be considered as a good tumoral marker in the detection of oat cell carcinoma of the lung.

Arginine Vasopressin↗
PubMed1979

[Smoking habit at school. First habit at school. First results of a survey done in Marseille and its suburbs (author's transl)].

The authors report the first results of a transversal survey done from the end of November 1976 to the end of April 1977 in 4 secondary schools (CES, CEG) in Marseille and its suburbs. 1.795 children, between 11 and 15, in the first and fourth form, filled up a questionary inquiring into their smoking habits and consumption. Already a certain number of results can be drawn: --in this group of children, mostly girls (926 G/882 B) 181 were regular smokers (10,07%); --among these smokers, 70 smoked every day (38,6%), 60 smoked more than a packet a week (33%), finally 122 inhaled smoke; --they acquired the habit of smoking regularly between the age of 14 and 15, in the 3rd and 4th forms, as there was only 9,4% of smokers in the 3rd and 19% in the 4th form; --finally, parents seem to play a fundamental inducing part in this habit, as among smoking children 32.8% have parents both smoking, 41% a smoking mother, 71.2% a smoking father, while for non smokers the percentage were respectively of 19.9%, 24.9% and 54.3%.

Adolescent↗
PubMed1979

[Radiotherapy of localized inoperable bronchial squamous cell carcinoma (author's transl)].

Authors have shown that in some favorable cases radiotherapy of localized bronchial carcinoma could give very good results. The study on the cases from 1960 to 1969 shows that authors have 8% of three years survival upon 105 patients who have been treated by 50 Grays or more in 5 weeks. The survival was better for the small cancers T2 than for the large ones. The study on the cases from 1970 to 1977 shows that to obtain 101 cases of squamous cell carcinoma (T2,4 -N0,2 -M0) authors were obliged to study 564 cases. The three years survival was 3,1% for carcinoma receiving more than 40 Grays/4 weeks. The survival is better for small cancer and for the cases without radiological mediastinal nodes. In conclusion, radiotherapy is the best treatment after surgery, limited disease can be cure, and iterative radiotherapy increases our results.

Bronchial Neoplasms↗
PubMed1978

Evaluation of the distribution of air and blood in emphysema patients using radioisotopic tracers.

Continuous recording of the respiratory cycle with the simultaneous or sequential radionucleic exploration (gamma camera) of ventilation (133Xe) and perfusion (MAT-99) was performed to determine the V/Q index in regional areas (Polaroid photography, mini-computer, memory visualization system, Benson incremental tracer, etc.) from the level of 1,024 points. An average ratio per sector was calculated and only three median sectors were retained. The wash-in and wash-out curves were traced by computer, and the calculation of the average T 1/2 for the different compartments of each median sector (apex--middle and base) was done in about 22 observations: in 18 diffuse emphysema, 11 of which were associated with giant cystic emphysema (spirometric, plethysmographic and radiographic data), T 1/2 values were greater than those of normal subjects (compartments C1 and C2) in diffuse emphysema and can become indefinable in zones of cystic emphysema. The values of the index V/Q approach the normal in diffuse emphysema with a tendency toward equalization of the ratios from the apex to the base. Extremely large divergence is observed in the elevated V/Q ratios in cystic emphysema.

Adult↗
PubMed1978

[Pulmonary nocardiosis].

Nocardioses are unusual broncho-pneumopathies with a dangerous evolution which should be better known. They occur usually, except in case no. 1, in patients with decreased immunity. For this reason they belong to superinfection with opportunist germs. It should be kept in mind when identfying the nocardia so as to start an early specific treatment.

Adult↗
PubMed1978

[beta2-Microglobulin and carcino-embryonic antigen in bronchogenic carcinoma (author's transl)].

In a series of 52 patients with bronchogenic carcinoma serum levels of beta2-microglobulin (beta2m) and carcino-embryonic antigen (CEA) were studied. No correlation was found between the increase of beta2m (greater than 3,2 mg/l) and CEA (greater than 40 ng/l). High levels were found in 10 % of cases for CEA and in 30% of cases for beta2m. The follow-up of serum levels of beta2m and CEA was studied during the evolution of the disease through monthly assays. Upon 15 cases followed, the same dissociation between beta2m and CEA was observed.

Beta-Globulins↗
PubMed1978

[beta2-Microglobulin and pulmonary tuberculosis (author's transl)].

Serum beta2-microglobulin levels, determined in 29 healthy adults were found to be 1,3 mg/l with an upper confidence limit (95%) of 2,0 mg/ml. In contrast, serum values in 101 patients with pulmonary tuberculosis were 2,1 mg/l with an upper confidence limit of 3,2 mg/l. The latter value is therefore to be taken into consideration if serum beta2m is to be used for discriminating between lung carcinoma and other pulmonary diseases.

Beta-Globulins↗
PubMed1977

[The value of body tomodensitometry for diagnosis in pneumology].

The authors present a preliminary work on 37 pulmonary tomodensitometry performed on 18 bronchial cancers, 7 pleuro-pulmonary metastases, 4 normal lungs and 8 various respiratory diseases. This method presents a double advantage:--first it localizes the affection in relation to pleura, mediastinum or heart; specially interesting in case of a transparietal puncture in carcinology;--secondly, densitometry enables a differentiation between dense tumoral tissue and ventilatory disorders or pleurisy; it is also useful in determining the tumoral target volume. Finally this new technique can show air cavities (emphysema, tuberculous or cancerous caverns) as well as pleurisies of small volume.

Adolescent↗