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Biomedical subjects

R Pohl

Publications and source records attributed to R Pohl.

154 records · Page 9Linked to original sources
PubMedDate not supplied

Relationship between age and heart rate variability in supine and standing postures: a study of spectral analysis of heart rate.

We compared heart rate variability measures of 11 normal children (4-12 years) to 23 normal adults (21-43 years) to study the effect of age on heart rate variability measures. Children had a significantly higher supine and standing heart rate and lower supine and standing systolic and diastolic blood pressure. Children also had a significantly higher supine standard deviation of HR, supine low frequency (0.01-0.05 Hz) (p < 0.005), supine high frequency (0.2-0.5 Hz) (p < 0.001), and standing high frequency powers (p < 0.005) compared to adults. The ratio of mid frequency (0.07-0.15 Hz) to high frequency power (0.2-0.5 Hz) upon standing was significantly lower in children (p < 0.005). While there was a significant increase of the mid frequency power from supine to standing posture in the adult group (p < 0.02), there was no such significant increase in children. There were also significant negative correlations between age and supine low frequency, mid frequency, and high frequency powers, and standing high frequency power. These findings illustrate a decrease of cholinergic and an increase of adrenergic modulation of heart rate variability with age (4-43 years).

Adrenergic Fibers↗
PubMedDate not supplied

Effect of age on QT variability.

Heart rate variability is influenced significantly by age. Recent studies have shown the utility of QT variability to study temporal repolarization lability, and increased QT variability is reportedly associated with sudden death. Because beat-to-beat QT interval variability appears to closely follow heart rate variability, this study investigated the relationship between age and QT variability. We obtained QT variability measures in 34 adults (22-55 years of age) and 15 children (6-14 years of age) using a novel algorithm to compute beat-to-beat QT intervals. QT variability corrected for mean QT interval was significantly inversely correlated with age. Coherence in the band of 0 to 0.5 Hz and high-frequency coherence (0.15-0.5 Hz) were also significantly inversely correlated with age. QTvi (QT variability corrected for mean QT interval over heart rate variability corrected for mean heart rate) was not significantly related to age in supine posture during spontaneous or controlled breathing, whereas there was a modest negative relationship in standing posture. These findings suggest that coherence between QT and heart rate time series appears to be modulated by cardiac vagal activity.

Adolescent↗
PubMedDate not supplied

Azaspirodecanediones in generalized anxiety disorder: buspirone.

Buspirone is a new anxiolytic that is structurally unrelated to other psychotropic drugs. The drug is as effective as benzodiazepines for the treatment of generalized anxiety, and superior to placebo. The effect of buspirone on other anxiety disorders, such as panic disorder or post-traumatic stress disorder, remains untested. Although buspirone's mechanism of action is unknown, it clearly does not act on the same receptor systems that are affected by benzodiazepines. Buspirone appears to lack dependence and abuse potential and has little or no sedative effect. In addition, the drug does not potentiate sedative-hypnotic drugs and does not potentiate functional impairment produced by alcohol. Like benzodiazepines, buspirone appears to be safe even when given in very high doses.

Anxiety Disorders↗
PubMedDate not supplied

Preinfusion anxiety predicts lactate-induced panic attacks in normal controls.

Preinfusion anxiety, heart rate, and blood pressure were measured in 31 normal subjects who received sodium lactate infusions. Eight subjects developed symptoms of panic anxiety during these infusions. Preinfusion anxiety as measured by psychologic symptoms of anxiety on the Panic Description Scale was significantly higher in the panickers while heart rate and blood pressure were not.

Adult↗
PubMedDate not supplied

Heart rate and blood pressure during placebo-associated panic attacks.

Increases in the anxiety ratings, heart rate, and systolic and diastolic blood pressure were compared in eight panicking and 57 nonpanicking panic disorder patients during placebo (dextrose) infusions. Heart rate and systolic and diastolic blood pressure increased significantly in placebo-infused panickers, but these increases did not correlate well with increases in anxiety.

Adult↗
PubMedDate not supplied

Risk factors for cardiovascular illness in panic disorder patients.

Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine and standing cardiac load measures compared to both patient nonsmokers and controls. There was no significant difference between controls and nonsmoking patients for any of the above measures except for the higher standing HR and the delta increase in HR upon standing in female panic disorder patients which suggests increased adrenergic activity. When lipid values of panic disorder patients (n = 92) were compared to National Reference Values for their sex and age for an increased risk of cardiovascular illness, there was no significant risk with regard to plasma levels of total cholesterol, high-density lipoprotein cholesterol or low-density lipoprotein cholesterol.

Adult↗
PubMedDate not supplied

Designing healthcare regions: a Canadian approach.

Regionalizing healthcare delivery is a means to control rising costs and improve service delivery. The authors reviewed current and proposed healthcare regionalization models across Canada, and summarized their findings regarding several key factors. Their research on regionalization has led them to develop guidelines directed at those involved in planning and implementing healthcare regionalization.

Canada↗