Search PubMed⌕ Search

Biomedical subjects

R Plomin

Publications and source records attributed to R Plomin.

At least 145 records · Page 8Linked to original sources

Genetics and psychiatry: an unheralded window on the environment.

Two recent reviews in the American Journal of Psychiatry and the British Journal of Psychiatry reported on progress in understanding the genetics of psychiatric disorder. Both reviews focused on this progress as a prelude to psychiatric diagnostics and therapeutics based on molecular biology. Neither review recognized that the latest data in behavioral genetics support environmental causes for abnormal development and psychopathology as much as they support genetic causes. Moreover, these genetic data point clearly to a type of environmental cause with central importance: the environment that is specific or unique to each sibling in a family.

Adolescent↗

Natural cohorts: family similarity in adult cognition.

We now return to the sets of hypotheses formulated in the introductory section to explore how the findings reported above bear on these propositions. Our first hypothesis dealt with whether family similarity could be observed in adulthood and whether there were differing ability patterns in such similarity. Significant family similarities were observed for our total sample for all ability measures, except Perceptual Speed, and for the cognitive style measures. The magnitude of correlations for the ability measures are comparable for those found between young adults and their children (DeFries et al., 1976). Similar to the DeFries study, we also found differences in resemblance across subsets. For example, same gender pairs showed higher correlations on Verbal Meaning, Number, and Word Fluency but opposite-gender pairs on Spatial Orientation, Inductive Reasoning, and Motor-Cognitive Flexibility. Also, greater similarity was found between mother-offspring pairs than father-offspring pairs on Inductive Reasoning and Psychomotor Speed. Moreover, higher parent-offspring correlations were found for daughters than for sons, suggesting at least the possibility that females may experience greater shared environmental influences than males. Our first hypothesis also argued for the possible effect of early shared environment upon offspring performance on Verbal Meaning and Word Fluency. After age adjustment, these were indeed the abilities that showed the highest parent-offspring similarity. Our second hypothesis proposed that if shared environmental influences are relatively unimportant in adulthood, then similarity within parent-offspring pairs should remain reasonably constant in adulthood across time and age. Our examination of this issue with a longitudinal sample ranging over a 21-year period strongly supports this proposition for all of those variables that displayed significant parent-offspring correlations. Indeed, parent-offspring correlations measured at approximately the same age of parent and offspring and when those ages were 20 years apart had similar magnitudes. The third hypothesis asked whether family similarity would decrease with age because of the increasing amount of nonnormative, nonshared environment expected as adult life progresses. Counterintuitively, no such decrease in similarity could be observed. Indeed, for two variables there was evidence for increasing similarity as a function of offspring age. This finding makes good sense for our Perceptual Speed variable. Most of our younger offspring typically have not yet experienced age-related decline on this variable, whereas some of their parents have. Both older offspring and parents may have experienced sufficient decline so that once again their observed similarity is increased.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

The role of inheritance in behavior.

Inheritance plays a major role in behavior as shown by selection and strain studies for animal behavior and by twin and adoption studies for human behavior. Unlike simple Mendelian characteristics, genetic variance for behavioral dimensions and disorders rarely accounts for more than half of the phenotypic variance, and multiple genes with small effects appear to be involved rather than one or two major genes. Genetic research on behavior will be transformed by techniques of molecular biology that can be used to identify DNA sequences responsible for behavioral variation. However, the importance of nongenetic factors and the multigenetic control of behavior require new strategies to detect DNA markers that account for small amounts of behavioral variation.

Animals↗

Differences in heritability across groups differing in ability.

Differences in heritability and environmentality were assessed for 54 DZ and 86 MZ same-sex twin pairs between 6 and 12 years of age from the Western Reserve Twin Project. A principal-component score composed of the subtests of the WISC-R, PPVT, WRAT, and MAT represented each twin's cognitive ability. Using a modification of a regression technique developed by DeFries and Fulker (1985), it was possible to assess differential heritability and environmentality across ability level. A number of variants of this procedure were used and all yielded the same result: lower ability subjects show higher heritabilities and lower shared environmentality. This result is attributable to larger differences between DZ twins at low ability levels and to differences between MZ twins, which are either the same across ability level or are smaller at low ability levels. A possible explanation for this effect is a genotype-environment correlation in which higher-ability persons seek out better environments. The results from this study should be regarded as tentative but the methods used can be applied to other twins studies. Investigators should be aware of the importance of representing the low end of the distribution in their samples.

Achievement↗

Who discovered the twin method?

The twin method is usually credited to Francis Galton's 1875 article on twins. However, Galton did not propose the comparison between identical and fraternal twin resemblance which is the essence of the twin method. Although the twin method was "in the air" in the mid-1920s, the first descriptions of the method appeared in an article by Curtis Merriman and in a book by Hermann Siemens, both in 1924, 50 years after Galton's paper.

Genetics, Behavioral↗

Genetic influence on life events during the last half of the life span.

Genetic influence on perceptions of major events later in life was assessed with a combination of twin and adoption designs as part of the Swedish Adoption/Twin Study of Aging (SATSA). The SATSA design includes 4 groups totaling 399 pairs of same-sex twins: identical and fraternal twins reared apart and matched twins reared together. The average age of the twins was 59 years. The results demonstrate significant genetic influence on reports of the occurrence of life events, especially for controllable events in which the individual can play an active role. Maximum likelihood model-fitting estimates of genetic influence indicate that 40% of the variance of the total life events score is due to genetic differences among individuals. How genetic factors can affect life experiences and directions for future research are discussed.

Humans↗

Genetic and environmental influences on social support: the Swedish Adoption/Twin Study of Aging.

A new direction in behavioral genetic research is the exploration of genetic influences on ostensibly environmental measures. The goal of the present study was to identify genetic as well as environmental influences that contribute to an individual's motivation and ability to create and maintain social support systems during the second half of the life course. One of the most powerful behavioral genetic designs is the combined twin/adoption design which is used in the Swedish Adoption/Twin Study of Aging (SATSA). A subsample of 424 pairs of twins age 50 and above was used: 64 pairs of identical twins reared apart, 95 pairs of identical twins reared together, 132 pairs of fraternal twins reared apart, and 133 pairs of fraternal twins reared together. The measure of social support assessed both the quantity of relationships as well as the perceived adequacy of the social support network. Model-fitting analyses verified the importance of genetic factors for perceived adequacy of the social support network, whereas little genetic influence was found for the quantity of social relationships.

Adoption↗

Behavioral genetics and personality change.

Although research on personality and behavioral genetics has focused on the continuity of traits, both fields and their interface will profit from the consideration of trait change. In this article we review personality research on age differences in heritability and propose the counterintuitive hypothesis that, when developmental changes in heritability are found, heritability tends to increase. We also focus on behavioral genetic analyses of long-term developmental change. Research to date suggests that genetic involvement in adult personality change is slight whereas personality change in childhood is governed substantially be genetic factors. Finally, we consider a new topic, genetic influence on short-term change in personality.

Adolescent↗

Assessing the relationship between young siblings: a research note.

Methods for assessing the sibling relationship differ markedly, yet these have rarely been compared, or assessed in terms of retest reliability. We report an examination of sibling relationships as assessed by maternal interview, by videotaped observation in structured and semi-structured situations, and by naturalistic observation in unstructured settings. The different approaches to assessment were compared with data on 84 sibling pairs aged between 3 and 10 years. Test-retest reliabilities, assessed on 30 pairs studied on a second occasion, were good for maternal interview information, moderate for videotaped observations, and mixed for naturalistic observations. Independent positive and negative dimensions of the relationship were revealed by each method, and moderate agreement found between methods. Naturalistic observations of 30 minutes' duration were unsuitable for studying the negative aspects of the relationship.

Child, Preschool↗

Direct and indirect IQ heritability estimates: a puzzle.

Direct estimates of IQ heritability based on a single family relationship such as adopted-apart relatives are often 50% greater than indirect estimates that rely on differences in correlations such as the classical twin method or nonadoptive-adoptive comparisons. Factors such as nonadditive genetic variance, assortative mating, selective placement, measurement error, age differences, and genotype-environment correlation and interaction do not obviously explain the difference between direct and indirect IQ heritability estimates. Because direct estimates are derived from separated individuals and indirect estimates are derived from individuals reared together in families, some aspect of the within-family environment seems a likely candidate but its exact nature remains to be understood.

Adoption↗

Environment and genes. Determinants of behavior.

Recent behavioral genetic research has demonstrated that genetic influence on individual differences in behavioral development is usually significant and often substantial and, paradoxically, also supports the important role of the environment. This article reviews research on the heritability of intellectual factors, personality factors, and psychopathology. It discusses the importance of investigating within-family environmental differences in order to understand the environmental origins of individual differences in development.

Child↗

Individual differences in locus of control during the second half of the life span for identical and fraternal twins reared apart and reared together.

The relative influences of genetic and environmental factors for components of locus of control (LOC) were examined in the Swedish Adoption/Twin Study of Aging. The sample consisted of 84 pairs of monozygotic twins separated at an early age and reared apart, 173 pairs of dizygotic twins reared apart, 129 monozygotic pairs reared together, and 168 dizygotic pairs reared together. At the time of data collection, 72% were over 50 years of age. Three LOC components were measured in a mailed questionnaire: sense of personal control or lack of control over the direction of one's own life (Life Direction), beliefs about how responsible people are for misfortunes in their lives (Responsibility), and beliefs concerning the role of luck in determining people's outcomes (Luck). Model-fitting results indicated that genetic influences were of importance for Life Direction and Responsibility, accounting for somewhat over 30% of the variance in each component, while environmental influences explained twin similarity for Luck.

Adoption↗

Neuroticism, extraversion, and related traits in adult twins reared apart and reared together.

The relative importance of genetic and environmental factors for neuroticism, extraversion, impulsivity, and monotony avoidance were estimated in a sample of 99 monozygotic and 229 dizygotic pairs of twins reared apart (TRA) and a matched sample of 160 monozygotic and 212 dizygotic pairs of twins reared together (TRT). The average age was 58.6 (SD = 13.6); 72% of the twins were 50 or older. Model-fitting analyses verified the importance of genetic factors for all four measures; from 23% to 45% of the total variation was attributable to genetic sources. There was considerable evidence that these factors were operating in a nonadditive manner for extraversion and impulsivity. Shared environment accounted for less than 10% of the variance; some evidence for selective placement was found for neuroticism.

Diseases in Twins↗

EAS temperaments during the last half of the life span: twins reared apart and twins reared together.

In this first behavioral genetic study of personality in the last half of the life span, results are reported using the powerful adoption/twin design that compares identical and fraternal twins reared apart and identical and fraternal twins reared together. Traits studied were the EAS temperaments (emotionality, activity level, and sociability), traits that show substantial genetic influence in childhood. It was hypothesized that the EAS traits would also show significant genetic influence later in life and that most of the environmental variation would be nonshared--that is, twins reared together would show no greater resemblance for the EAS traits than twins reared apart. Both hypotheses are supported.

Adoption↗

Genotype-environment interaction in personality development: identical twins reared apart.

The focus of this study is to identify specific genotype-environment (GE) interactions as they contribute to individual differences in personality in later life. In behavioral genetics, GE interaction refers to the possibility that individuals of different genotypes may respond differently to specific environments. A sample of 99 pairs of identical twins reared apart, whose average age is 59 years, has been studied as part of the Swedish Adoption/Twin Study of Aging (SATSA). Hierarchical multiple regression was used to detect interactions between personality and environmental measures after the main effects of genotype and environment were removed. Analyses yield evidence for 11 significant interactions that provide the first evidence for GE interaction in human development using specific environmental measures. Thus, in addition to the main-effect contributions of heredity and environment, GE interactions contribute to individual differences in personality as measured in the second half of the life course.

Adoption↗