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R Plomin

Publications and source records attributed to R Plomin.

At least 109 records · Page 6Linked to original sources
PubMed1995

Parent ratings of EAS temperaments in twins, full siblings, half siblings, and step siblings.

A twin/family design was used to explore genetic contributions to personality; to evaluate whether twins and nontwins yield different genetic results; and to test for the presence of contrast effects, the tendency of a rater to contrast one sibling with the other, thereby magnifying existing behavioral differences. The sample consisted of 708 adolescent same-sex sibling pairs from 10 to 18 years of age. Pairs included identical (monozygotic; MZ) and fraternal (dizygotic; DZ) twins, and full siblings in nondivorced families; and full, half, and unrelated siblings in stepfamilies. Mothers and fathers rated the temperament of their children on the EAS Temperament Survey (A. H. Buss & R. Plomin, 1984). Model-fitting analyses revealed significant genetic influences on each of the four EAS dimensions; however, for some dimensions, heritability estimates were significantly greater for twins than for nontwins. Overall, the data were best described by a sibling interaction model, which indicated significant contrast effects.

Adolescent↗
PubMed1995

Traits and metatraits: their reliability, stability, and shared genetic influence.

Metatraits measure individual differences in construct relevancy, whereas traits measure individual differences in construct extremity. Twenty-four traits and metatraits were examined in this study using 157 pairs of identical twins reared together, 95 pairs of identical twins reared apart, 211 pairs of fraternal twins reared together, and 228 pairs of fraternal twins reared apart obtained from the Swedish Adoption/Twin Study of Aging (see N. L. Pedersen et al., 1991). Reliability and stability analyses of the metatraits revealed generally lower reliability and stability across time compared to traits. Quantitative genetic analyses of the relationship between traits and metatraits indicated that approximately 69% of the metatrait's genetic variance is shared with the trait, with 31% of its genetic variance unique to the metatrait. These results suggest that metatraits provide a useful additional view of personality.

Adoption↗
PubMed1995

A twin study of competence and problem behavior in childhood and early adolescence.

The Child Behavior Checklist (CBCL) was completed by parents of 181 pairs of same-sex twins ages 7-15 (mean age = 11.0 years). Correlations between scores on the CBCL scales for 99 pairs of monozygotic twins and 82 pairs of dizygotic twins indicated significant genetic influences that varied according to the specific area of competence and problem behavior. Model-fitting estimates derived from multiple regression analyses indicated significant genetic influence on competence in school and on all areas of problem behavior. In addition, significant shared environmental influence was detected for amount and quality of participation in activities, quality of social relationships, performance in school, anxiety/depression, and delinquent behaviour. Implications for future work on the mechanisms underlying these effects are discussed.

Adolescent↗
PubMed1995

Genetics and children's experiences in the family.

Genetic research may have its greatest impact for clinicians and developmental researchers in terms of understanding the environment and how the environment relates to children's development. This review focuses on one example at the interface between nature and nurture. Recent research using diverse genetic designs shows that family environment as it is currently assessed involves a substantial contribution from genetic factors. Genetic factors also contribute to correlations between measures of the family environment and developmental outcomes. Implications of these findings are discussed.

Adoption↗
PubMed1995

Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains.

Quantitative trait loci (QTL) mapping of complex phenotypes has emerged as an important feature of the recombinant inbred (RI) strain methodology. In this second study of our series on alcohol-related behaviors in mice, we examine alcohol acceptance, preference, and hypnotic dose sensitivity (HDS) to a standard dose of alcohol measured in BXD RI strains to identify candidate QTL regions responsible for their heritability. We detected highly significant marker associations for acceptance on chromosome 12 (Eif4e), for preference on chromosome 1 (D1Rti2) and chromosome 7 (D7Mit7), and for HDS on chromosome 7 (Mpmv1). These are the strongest QTL associations that we detected, but several other candidate QTL regions are reported. Given the limited number of BXD RI strains available, the large number of markers used herein, and the consequent chance of identifying false marker associations, these RI QTL mapping results must be seen as tentative, but an important first step toward identifying QTL for alcohol-related behaviors.

Alcohol Drinking↗
PubMed1995

A twin-sibling study of observed parent-adolescent interactions.

Numerous behavioral genetic studies call attention to the strong and pervasive genetic influence on developmental characteristics. However, this research has been criticized for its use of poor environmental measures and a failure to examine the complex processes that are a hallmark of research in child development. This study addresses this criticism by examining the genetic and environmental components of parent-child interactions. Mother, father, and 2 adolescent siblings (10-18 years) from each of 675 families were observed interacting in 10-min dyadic problem-solving sessions. 6 groups of siblings that differed in genetic relatedness were examined (MZ and DZ twins, full siblings in nondivorced families; full, half, and unrelated siblings in stepfamilies). Results suggest a greater genetic component to adolescent behavior than to parent behavior. Both adolescent and parent behavior showed strong effects of nonshared environment, even after error of measurement was removed.

Adolescent↗
PubMed1994

The genetic basis of complex human behaviors.

Quantitative genetic research has built a strong case for the importance of genetic factors in many complex behavioral disorders and dimensions in the domains of psychopathology, personality, and cognitive abilities. Quantitative genetics can also provide an empirical guide and a conceptual framework for the application of molecular genetics. The success of molecular genetics in elucidating the genetic basis of behavioral disorders has largely relied on a reductionistic one gene, one disorder (OGOD) approach in which a single gene is necessary and sufficient to develop a disorder. In contrast, a quantitative trait loci (QTL) approach involves the search for multiple genes, each of which is neither necessary nor sufficient for the development of a trait. The OGOD and QTL approaches have both advantages and disadvantages for identifying genes that affect complex human behaviors.

Genetics, Behavioral↗
PubMed1994

Variability and stability in cognitive abilities are largely genetic later in life.

The powerful quantitative genetic design of identical and fraternal twins reared apart (112 pairs) and matched twins reared together (111 pairs) was employed to assess the extent of genetic influence on individual differences in cognitive abilities during the last half of the life span. General cognitive ability yielded a heritability estimate of about .80 in two assessments 3 years apart as part of the Swedish Adoption/Twin Study of Aging. This is one of the highest heritabilities reported for a behavioral trait. Across the two ages, average heritabilities are about .60 for verbal tests, .50 for spatial and speed-of-processing tests, and .40 for memory tests. For general cognitive ability, the phenotypic stability across the 3 years is .92 and stable genetic factors account for nearly 90% this stability. These findings suggest that general cognitive ability is a reasonable target for research that aims to identify specific genes for complex traits.

Aging↗
PubMed1994

Continuity and change in infant shyness from 14 to 20 months.

Objective measures of shyness in the MacArthur Longitudinal Twin Study were obtained in two testing situations: the laboratory and the home. A longitudinal hierarchical model was fitted to the data, allowing estimation of the extent to which genetic, shared environmental, and unique environmental influences contributed to continuity and change of the shyness phenotype from 14 to 20 months of age. The sample consisted of 163 monozygotic and 138 same-sex dizygotic twin pairs. Models were fitted to raw data using a maximum-likelihood pedigree approach. Genetic, shared environmental, and unique environmental first-order factors, with specific variances, were modeled on each of four shyness ratings assessed in the laboratory and home at 14 and 20 months. Four second-order genetic, shared environmental, and unique environmental factors were also modeled. Results indicated that developmental change from 14 to 20 months and situational specificity between the laboratory and the home are mediated largely by shared and unique environmental influences. Genetic variation is largely responsible for both the stability in shyness from 14 to 20 months and the phenotypic correlations observed between the laboratory and the home settings.

Female↗
PubMed1994

DNA markers associated with high versus low IQ: the IQ Quantitative Trait Loci (QTL) Project.

General cognitive ability (intelligence, often indexed by IQ scores) is one of the most highly heritable behavioral dimensions. In an attempt to identify some of the many genes (quantitative trait loci; QTL) responsible for the substantial heritability of this quantitative trait, the IQ QTL Project uses an allelic association strategy. Allelic frequencies are compared for the high and low extremes of the IQ dimension using DNA markers in or near genes that are likely to be relevant to neural functioning. Permanent cell lines have been established for low-IQ (mean IQ = 82; N = 18), middle-IQ (mean IQ = 105; N = 21), and high-IQ (mean IQ = 130; N = 24) groups and for a replication sample consisting of even more extreme low-IQ (mean IQ = 59; N = 17) and high-IQ (mean IQ = 142; N = 27) groups. Subjects are Caucasian children tested from 6 to 12 years of age. This first report of the IQ QTL Project presents allelic association results for 46 two-allele markers and for 26 comparisons for 14 multiple-allele markers. Two markers yielded significant (p < .01) allelic frequency differences between the high- and the low-IQ groups in the combined sample-a new HLA marker for a gene unique to the human species and a new brain-expressed triplet repeat marker (CTGB33). The prospects for harnessing the power of molecular genetic techniques to identify QTL for quantitative dimensions of human behavior are discussed.

Alleles↗
PubMed1994

Genetic and environmental influences on pulmonary function in aging Swedish twins.

BACKGROUND: In addition to their value in assessing pulmonary health and disease, spirometric variables have been shown to be powerful predictors of time until death in aging populations. The sources of variability in these spirometric values are consequently of relevance to basic gerontological research, and also of potential value in clinical application. The objective of this study was to estimate genetic and environmental sources of variance in pulmonary function. METHODS: The study involved 230 Swedish twin pairs (mean age = 64.9 years), of which number 37 monozygotic (MZ) pairs and 72 dizygotic (DZ) pairs had been separated and reared apart. Comparing these groups to the 57 MZ and 64 DZ pairs reared together permits stronger interpretation than that of conventional twin studies. Measures of vital capacity (VC) and forced expiratory volume in one second (FEV1) were residualized for height, age, sex, and tobacco consumption in pack-years. RESULTS: Maximum likelihood analyses of VC and FEV1 gave heritability estimates of .48 and .67, respectively. Age effects were explored both by dividing the sample into two cohorts, respectively above and below 65 years, and by moving interval analysis. In the two-cohort analysis, heritabilities were somewhat higher for the older cohort than the younger cohort for FEV1. The opposite was true for VC: heritability was lower in the older cohort, and there was evidence for a shared rearing environmental effect for this group. Moving interval analysis suggests these differences are gradual rather than saltatory. There were no gender differences in parameter estimates. CONCLUSION: Genetic factors account for between one-half and two-thirds of the variability in pulmonary function. There is a suggestion of age differences in the relative importance of genetic and environmental influences.

Adult↗
PubMed1994

Genetic and environmental influences on perceptions of self-worth and competence in adolescence: a study of twins, full siblings, and step-siblings.

Although it is generally assumed that the origins of adolescents' perceptions of self-competence lie in shared family environmental influences, the contributions of nonshared environmental or genetic influences have not been explored. We investigated sibling resemblance for perceived competence and self-worth in 720 adolescent pairs aged 10 to 18 years, using a twin, full sibling, and step-sibling design. Our goals were to assess the magnitude of shared and nonshared environmental influences and to disentangle resemblance due to shared genetic heritage from that due to shared environmental experiences. Shared environment was not significant for any of the scales. 4 of the subscales showed significant genetic influence: scholastic, social, physical, and athletic competence. We also explored possible sources of genetic influences on perceived competence. Bivariate models revealed common genetic variance between scholastic competence and vocabulary and social competence and sociability. These measures, however, did not account for all of the genetic variance in perceived social and scholastic competence.

Achievement↗
PubMed1994

The Emanuel Miller Memorial Lecture 1993. Genetic research and identification of environmental influences.

As the importance of genetic influence in developmental psychopathology becomes widely accepted, we should not lose sight of the importance of genetic research for the investigation and identification of environmental influences. First, genetic research provides the best available evidence for the importance of nongenetic factors in behavioural development. Rarely does genetic influence account for more than half of the variance. Second, genetic research indicates that environmental effects on behavioural development largely involve nonshared environmental processes that make children in the same family different from one another. New research on this topic is presented and implications for research are discussed.

Adoption↗
PubMed1994

Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BXD recombinant inbred strains.

Although the recombinant inbred strain method was designed for molecular genetic analysis of linkage, it also provides powerful quantitative genetic analyses of heritability and genetic correlations. Measures of alcohol acceptance, alcohol preference, and hypnotic dose sensitivity (HDS) were assessed in 21 strains of mice from the BXD RI series. Sex differences were found to be significant at a phenotypic level. However, heritability estimates for acceptance, preference, and HDS are similar in males and females. Heritability estimates for the three measures are approximately 0.20 for acceptance and preference, and 0.10 for HDS. Analyses of genetic correlations reveal that acceptance and preference share some degree of genetic influence, although they mostly operate under different genetically mediated mechanisms. HDS did not show a significant genetic relationship to either acceptance or preference. Strong correlations were obtained when acceptance, preference, and HDS strain means were correlated across male and female recombinant inbreds, suggesting substantial genetic similarity across sexes.

Alcohol Drinking↗
PubMed1993

Genetics and high cognitive ability.

More is known about the genetics of general cognitive ability (g) than any other trait in psychology. Recent findings on the genetics of g include the following three examples: (1) heritability increases throughout the lifespan; (2) heritabilities of performance in cognitive tests are strongly correlated with the tests' loadings on a g factor; and (3) genetic effects on scholastic achievement largely overlap with genetic effects on cognitive ability. This body of genetic research addresses the aetiology of individual differences in the normal range. Much less is known about the genetics of the high end of the distribution. Finding heritability in the normal range of cognitive ability does not imply that high ability is also genetic in origin. However, the first twin study of high IQ children, which uses a new technique that analyses the average difference between extreme groups and the rest of the population, suggests that high IQ is as heritable as individual differences in the normal range. We are currently engaged in a molecular genetic study that attempts to identify specific genes that contribute to high ability.

Adolescent↗
PubMed1993

Quantitative trait loci (QTL) analyses and alcohol-related behaviors.

Recombinant inbred (RI) strains can make an important contribution toward the merger of molecular genetics and quantitative genetics in the quest for quantitative trait loci (QTL). We present preliminary analyses of alcohol-related processes from our ongoing research using the BXD RI series. Issues concerning reliability, genetic correlations, and RI QTL analysis are discussed. Several strategies for replication and extension of QTL candidate regions are considered: F1 crosses between RI strains, F2 crosses, heterogeneous stock, interspecific backcrosses, QTL selection, and the use of murine QTL in chromosomal regions syntenic to human chromosomes as candidate chromosomal regions for human QTL.

Alcohol Drinking↗
PubMed1993

Differences in heritability across groups differing in ability, revisited.

Three recent studies have used twin data to explore the possibility of differential contributions of heritability and environmentality to individual differences in cognitive ability as a function of ability level (Detterman, D. K., et al., Behav. Genet. 20:369-384; 1990; Bailey, M. J. and Revelle, W., Behav. Genet. 21:397-404, 1991; Cherny, S. S., et al., Behav. Genet. 22:153-162, 1992). All arrived at different conclusions: higher heritability at the low end, higher heritability at the high end, and no differential influence, respectively. The current report involves a sample of 148 identical and 135 fraternal twin pairs from the Western Twin Project who were tested on a battery of intelligence and achievement tests to further explore the issue. The results suggest no significant differences in heritability at either the high or the low end, although a trend toward higher heritability for children of higher ability is evident. Individual differences for a composite ability/achievement score showed significantly greater influence of shared family environment at the low end than the rest of the distribution. In general, results for cognitive ability and academic achievement were highly similar.

Adolescent↗