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Biomedical subjects

R Pirani

Publications and source records attributed to R Pirani.

31 records · Page 2Linked to original sources
PubMed1984

[Electrophysiologic effects of propafenone in patients with sinus node dysfunction].

The electrophysiologic effects of intravenously administered Propafenon (1,5 mg/kg) were evaluated in 16 patients (mean age: 62,1 +/- 11 years) with sinus node dysfunction, shown by sinus bradycardia or intermittent sino-atrial block. The variations of sinus cycle length were not statistically significant (NS), (1137,1 +/- 244,9 msec versus 1191,9 +/- 321,1 msec). In one patient sinus rate markedly decreased from 36 to 28 beats/min. In 2 patients the cycle length of a junctional rhythm was comparable before and after drug administration; in both patients the rate of the junctional rhythm decreased and in one markedly (from 39 to 32 beats/min). Sinoatrial conduction time increased in 4 patients and decreased in 6. The variations were not statistically significant (223,8 +/- 76 msec versus 230,6 +/- 75,9 msec). In one patient the sinoatrial conduction time which was normal during the control study, could not be evaluated after Propafenon due to the appearance of a retrograde block between the atrium and the sinus node. Maximum corrected sinus node recovery time was prolonged by the drug in 9 patients and shortened in 5. In 2 patients the sinus node recovery time was prolonged to about 10 sec. The mean value of corrected sinus node recovery time increased from 883,6 +/- 995,8 msec to 1820,5 +/- 2894 msec (NS). Propafenon significantly prolonged the effective refractory period and the functional refractory period of the atrium, as well as the A-H, H-V and QRS intervals, the A-V node functional refractory period, the relative refractory period of His-Purkinje system and the ventricular effective refractory period.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

One year efficacy and tolerability of oxprenolol slow-release and chlorthalidone on fixed combination in mild to moderate hypertension.

The long-term antihypertensive efficacy and tolerability of a fixed combination of oxprenolol 160 mg slow-release + chlortalidone 20 mg was studied in 40 out-patients with mild to moderate essential hypertension followed during one year with monthly clinical visits. The fixed combination was given at the dosage of 1 tablet once daily, in the morning, increasing to 1 tablet b.i.d. in case of lying diastolic blood pressure greater than 95 mmHg. After one year only 9 patients were on 1 tablet b.i.d., the others remaining on 1 tablet once daily regimen. Clear-cut antihypertensive effect was already evident after the 1st month of treatment. Both systolic and diastolic blood pressure further decreased after two months (p less than 0.01) showing then a constant trend to decrease till the 6th month; afterwards blood pressure values remained unchanged. Normalization of blood pressure was obtained in 63%, 73% and 80% of the patients, respectively after 1, 6 and 12 months of treatment. Laboratory data did not show significant changes. Only 3 patients complained of unwanted effects which were mild, transient and in no case compelled to interrupt the treatment. Results confirm that the fixed combination of oxprenolol 160 mg slow-release + chlorthalidone 20 mg is able to long term control mild to moderate hypertension with a good tolerability, thus allowing an improved patient compliance.

Adult↗
PubMed1980

[Dilazep].

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Animals↗
PubMed1979

[Short-term and median-term effects of tienilic acid in hypertension].

Fifty nine patients suffering from slight or moderate essential arterial hypertension underwent hypotensive treatment. After one week of wash-out, therapeutic administration of tienilic acid in doses of 500 mg per day was begun; in the third week we combined a non diuretic hypotensive drug (prazosin, propranolol, alfametil-dopa). At the beginning of the study all patients underwent an ECG, a clinical cardiological examiniation, funduscopy examination, funduscopy examination, a heart X - ray in 3 standard positions and a routine blood test which was repeated during and at the end of the treatment. The patients' blood pressure taken in an upright and supine position, showed statistically significant reductions for both systolic and diastolic values in all 3 groups, whereas the routine blood tests gave evidence of a marked reduction in the uriacid, triglycerides and potassium levels. In order to correct the latter we had to administer high oral doses of potassium, and in one case admittance to hospital was necessary since the potassium level was lower then 2.5 mEq/l.

Adult↗
PubMed1979

[Hemodynamic observations in a group of hypertensive patients treated with tienilic acid (author's transl)].

In ten patients suffering from slight or moderate essential arterial hypertension, undergoing treatment with tienilic acid at 500 mg per day, various hemodynamic parameters were assessed by means of ecocardiographic and policardiographic studies carried out before, during and at the end of treatment. In all cases a return to normal blood pressure values was achieved. No statistically significant changes in these parameters were observed, whereas the blood tests showed a reduction in the uric acid level and a moderate reduction in the potassium level.

Adult↗
PubMed1978

[A case of Churg-Strauss granulomatous angiitis: an autonomous clinical entity or a variant of panarteritis nodosa?].

A fatal case of Churg and Strauss granulomatous angiitis in a 21-yr-old woman is described. Its unusual features included marked personal and familial dysreaction, sudden onset, bronchopulmonitis with distinct eosinophilia and antibiotic- and cortisone-resistant pericarditis, and a terminal picture of generalised septico-pyaemia. The histological findings included necrotising systemic vasculitis with granulomas, some of them extravascular, in various organs. Differential diagnosis and the relation between this form and panarteritis nodosa are discussed.

Adult↗
PubMedDate not supplied

Reproducibility of electrophysiological parameters of sinus node following autonomic blockade.

We investigated the reproducibility of sinus node cycle length (SCL), corrected sinus node recovery time (CSRT) and sino-atrial conduction time (SACT) during the control state and following autonomic blockade in 25 patients (mean age: 56.9 +/- 13.8 years). Autonomic blockade was induced by i.v. administration of propranolol (0.2 mg/kg) and atropine (0.04 mg/kg). The electrophysiological study was repeated after 24 hr and the results were compared. The patients were divided into two groups: Group 1 (15) with normal and Group 2 (10) with abnormal intrinsic sinus node function. Following autonomic blockade in Group 1 the daily variations in SCL, CSRT and SACT were very slight whereas in Group 2 there was far greater variability in these parameters. However, in the latter group there were no patients who changed their status from prolonged to normal intrinsic CSRT on the second study, whereas SACT changed its status in 2 patients. In Group 1 the daily variations in sinus node parameters were much slighter following autonomic blockade than during the control state. In Group 2 the variations were very similar during control and following autonomic blockade. These data suggest that: (1) following autonomic blockade the reproducibility of sinus node parameters is very good in Group 1, whereas in Group 2 several patients show marked daily variations in sinus node parameters; (2) following autonomic blockade the sinus node electrophysiological parameters are meaningful in diagnosing an involvement of intrinsic sinus node function; and (3) in patients with abnormal sinus node parameters during control state, but with normal intrinsic sinus node function, the daily variations are mainly due to change in autonomic tone, whereas when the intrinsic sinus node function is abnormal, the day to day variations during control state appear due predominantly to intrinsic sinus node abnormalities.

Adolescent↗