Search PubMed⌕ Search

Biomedical subjects

R Pelletier

Publications and source records attributed to R Pelletier.

45 records · Page 3Linked to original sources
PubMed1984

Legionnaires' disease: the epidemiology of two outbreaks in Burlington, Vermont, 1980.

Eighty-five cases of Legionnaires' disease were diagnosed in two major outbreaks at a large regional medical center in Burlington, Vermont, in the summer of 1980. Cases in both outbreaks were positive for Legionella pneumophila, serogroup 1 by culture, serology, or direct fluorescent antibody tests. All cases had spent time in the city of Burlington in the 10 days before the onset of symptoms. Cases in both outbreaks were both hospital- and community-acquired. A case-control study identified no common in-hospital exposure, including shower use, that was associated with illness. Cases without previous exposure to the hospital were more likely to occur in persons with residences in neighborhoods just downwind of cooling tower A, but not throughout the municipal water system. Epidemiologic and environmental studies supported the association of this cooling tower, located 150 m from the hospital, with both outbreaks. Maintenance employees who worked with tower A had higher Legionella titers than those who worked with a comparison tower located 1.6 km away. Aerosolization of L. pneumophila by tower A and airborne spread to the hospital and community are postulated. The distance of airborne transmission of L. pneumophila in these consecutive outbreaks is greater than previously reported.

Cross Infection↗
PubMed1984

Do ischemic hearts stimulate endothelial cell growth?

The development of myocardial ischemia is known to elicit the formation and enlargement of collateral vessels. The stimulus for these events is unknown. We have investigated the possibility that cardiac tissue releases a factor that can stimulate endothelial cell proliferation. Hearts from New Zealand rabbits were made progressively ischemic by differential hypothermia. Extracts from these hearts were tested for their growth-stimulating ability and were found to increase the proliferation of fetal bovine aortic endothelial cells as well as DNA synthesis by 3T3 cells. The level of activity in the extracts appears to be related to the degree of ischemia as measured by creatine phosphokinase levels. The liberation of an endothelial cell growth factor by ischemic cardiac tissue may function in the initiation and/or potentiation of coronary collateral formation.

Animals↗
PubMedDate not supplied

Incoordination in patients with hemiparesis.

Incoordination is frequently observed in patients following a cerebrovascular accident. Clinical electromyographic studies which have furthered our understanding of this motor impairment are reviewed, and possible underlying mechanisms are discussed. It is suggested that the lack of coordinated voluntary movement observed in hemiparetic patients may be due, in part, to an impaired regulation of spinal neurones. In the rehabilitation sciences, the need to assess the effectiveness of treatment as well as develop new approaches for the treatment of hemiparetic subjects will require the combined efforts of many investigators. A two-fold research approach is supported which aims: 1) to quantify the motor deficit, and 2) to extend our knowledge of the physiological mechanisms underlying the deficit. Such a general research approach could be of value to the study of other sensorimotor deficits.

Electromyography↗
PubMedDate not supplied

[Intracytoplasmic sperm injection and Klinefelter syndrome].

Sperm cytogenetic study in two patients with Klinefelter's syndrome have demonstrated that there existed a risk low but highly significant, to transmit a sex chromosome abnormality to the offsprings. This result argues for a systematic karyotype before ICSI, and if such mosaïcs can be treated by ICSI, they must be firstly associated to a genetic counselling.

Fertilization in Vitro↗