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R Parry

Publications and source records attributed to R Parry.

52 records · Page 3Linked to original sources
PubMed1986

The effect of alcohol intake on the disposition of diphenhydramine in man.

The disposition of diphenhydramine (DPHA) and its principal metabolites was investigated in two subjects after i.v. and oral dosing. Based on these parameters the results of a multiple oral dose regimen were predicted and compared to the results obtained in these volunteers. During one dose interval of the multiple oral dose regimen, the volunteers indulged in social drinking. Comparison of this interval with a control period showed no differences in disposition. Alcohol therefore, would appear to have no effect on the disposition of DPHA.

Administration, Oral↗
PubMed1984

Toronto multiagency child abuse research project: the abused and the abuser.

Information from 422 cases of child mistreatment in Toronto was gathered from the files of a child welfare agency and a children's hospital. These data were compared to patterns reported in previous studies and clinical writings on child mistreatment to investigate similarities and differences in families whose children have been abused in Canada, England, and the United States. Findings from the present study were similar to others in many respects. The differences were primarily in the area of lower incidences of such problems as perinatal difficulties in the children and intellectual limitations and social isolation in the parents; however, there was a higher incidence of single-parent families. The results suggest that clinicians should bear in mind that child mistreatment cannot be ruled out on the grounds that no serious problems have been noted for the child or the family.

Canada↗
PubMed1984

Infection and interferon production in systemic juvenile chronic arthritis: a prospective study.

Twenty-four episodes of disease exacerbation in 19 children suffering from systemic juvenile chronic arthritis were studied. Sixteen of these were preceded by an infection (chi 2 = 20.14, p less than 0.001), mostly of the upper respiratory tract. In the 10 cases seen during an infection causative agents were identified in 5 (herpes simplex, rhinovirus, and on 3 occasions streptococcus). The total number of infections was not increased when compared with infection rates predicted by several reported studies. In the absence of clinical infection, specific antibody titres to a panel of microbial antigens were similar to those of a control group but with a trend toward higher titres in patients with hypergammaglobulinaemia. Interferon (IFN) responses were not defective, though sequential in-vitro IFN production from peripheral blood mononuclear cells (PBM) fluctuated considerably in the same patients, occasionally being absent with no obvious clinical correlate. IFN-alpha was induced by stimulation with Newcastle disease virus (NDV), and the mean responses of the patients were significantly greater than those of controls. IFN-gamma production on phytohaemagglutinin (PHA) stimulation was similar in patients and control groups. IFN was not detected in any of the sera from patients or controls.

Adolescent↗
PubMed1983

Respiratory disease associated with parainfluenza Type I (Sendai) virus in a colony of marmosets (Callithrix jacchus).

An outbreak of acute respiratory disease was observed in a colony of marmosets (Callithrix jacchus). Parainfluenza Type I (Sendai) virus was isolated from the lungs and from throat swabs of 2 animals which showed clinical signs of disease. A rising titre of serum neutralizing antibody to the virus isolated was detected in several affected animals. Approximately 50% of the colony showed clinical signs of disease, and 3 animals died. The duration of illness ranged from 3 to 16 days.

Age Factors↗
PubMed1983

Further studies of the cytopathic effect in tissue cultures inoculated with CSF from patients with schizophrenia and other nervous system diseases.

Tissue cultures were inoculated with CSF from patients with schizophrenia and some other psychiatric and neurological illnesses. The CPE was readily seen in all 13 strains of human skin fibroblasts examined but could not be serially passaged. The results of retesting many specimens, either by the same worker or under full double blind conditions, usually agreed and thus indicate that the CPE was due to the CSF and not to non specific changes in the cultures. CPE was seen in cultures in which mycoplasmas could not be detected. Degenerated cultures show polymorphous nuclei with condensed nuclear chromatin and enlarged mitochondria with few cristae but virus particles were not identified. The physical properties of the agent in the CSF that induced the CPE were the same as those reported earlier for CSF from schizophrenic patients.

Adult↗
PubMed1979

Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin.

This paper descirbes biosynthetic labeling experiments on the conversion of tyrosine to the C2- and C3-proline units of anthramycin, tomaymycin, and sibiromycin. The biosynthetic fate of all of the aromatic and side-chain hydrogens has been determined in each antibiotic by using dual tagged (3H/14C) and 2H-labeled tyrosine molecules. In addition, experiments uing [15N]tyrosine and the tritiated D and L isomers of tyrosine have shed some light on the biochemical reactions which take place at tha alpha position of tyrosine. On the basis of results of all these experiments, a biosynthetic scheme had been proposed to rationalize the apparent inconsistencies which occur between the results for the three antibiotics. This scheme proposes that a common main pathway involving proximal extradiol cleavage of Dopa and condensation to form the pyrrolo ring leads ultimately to a C-7 branch point compound. Parallel pathways from this central branch point compound lead by well-known biochemical transformations to the C2-and C3-proline units of anthramycin, tomaymycin, and sibiromycin. The reactions in these parallel pathways are suggested to be "cosmetic or after events".

Actinomycetales↗
PubMedDate not supplied

The disposition of diphenhydramine and four of its analogues in rabbits and implication for structure-activity relationship studies in drug design.

The disposition of diphenhydramine (I) and four of its ring substituted analogues, 4-bromodiphenhydramine (II), 4-methyldiphenhydramine (III), 2-methyldiphenhydramine (IV), and 4-t-butyldiphenhydramine (V), was investigated in the rabbit, during and after intravenous infusion. The concentration of each analogue was determined by gas-liquid chromatography (GLC) and the disposition parameters of clearance, volume of distribution, and elimination rate constant determined. These parameters were found to vary within the series, clearance increased in the order I less than IV less than III less than II less than V and volume of distribution in the order III less than 1 less than IV less than V less than II. These changes correlated with the Hansch hydrophobic substituent parameter: for clearance r = 0.97, for volume r = 0.7. The implication of these changes for the design of studies investigating the effects of structure on pharmacological response are discussed.

Animals↗
PubMedDate not supplied

How enrolled nurses feel about conversion.

Enrolled nurses work in a state of uncertainty. EN training ended in 1992 and health care assistants with NVQs are being employed in many areas. The UKCC's Rule 18, which sets out the scope of practice for ENs, is now under review. This article gives the results of a survey of ENs who have undertaken conversion to RGN.

Adult↗
PubMedDate not supplied

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Dyslexia↗