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Biomedical subjects

R Parodi

Publications and source records attributed to R Parodi.

17 recordsLinked to original sources
PubMed2000

Use of Emdogain in the treatment of deep intrabony defects: 12-month clinical results. Histologic and radiographic evaluation.

The objective of this study was to evaluate the application of an enamel matrix derivative (Emdogain) in deep periodontal pocket therapy. Twenty-one patients presenting intrabony and interproximal defects that could be treated with guided tissue regeneration were selected. The intrabony defects were divided into deep (< 9 mm) and very deep (> or = 9 mm) defects. Bleeding on probing, Plaque Index, probing pocket depth, mobility index, gingival recession, probing attachment level, and surgical bone level were measured at baseline. At 12 months, cases were reexamined and indices recorded again. The mean probing depth decreased from 8.1 +/- 2.1 mm to 3.2 +/- 1.5 mm; attachment level decreased from 10.4 +/- 2.4 mm to 7.0 +/- 1.8 mm; recession increased from 2.3 +/- 1.4 mm to 3.8 +/- 1.8 mm; and surgical bone level decreased from 9.6 +/- 1.9 mm to 7.1 +/- 1.5 mm. No significant difference wa noted between bone defects with one or 2 walls, between local and generalized periodontitis, or between smokers and nonsmokers. Significant statistical difference was found, however, between deep intrabony defects and very deep defects when attachment gain was considered. No adverse reaction to the substance was noted. The good clinical results obtained were not confirmed by radiologic results; standardized and computerized radiographs at 12 months did not reveal significant improvement. The histologic examination carried out on 2 samples did not show evidence of new attachment. Further studies are necessary to clarify the action mechanism and to evaluate the long-term results of this method.

Adult↗
PubMed1998

Implant placement in large edentulous ridges expanded by GBR using a bioresorbable collagen membrane.

The purpose of this study is to evaluate the possibility of expanding an edentulous ridge spanning two or more teeth by a two-step technique with bioresorbable collagen membranes. Sixteen healthy patients were treated, four in the mandible and 12 in the maxilla. The borderline of the crest width was less than or equal to 4 mm. In each patient only one ridge augmentation was performed. After elevation of a full-thickness flap, a surgical stent was positioned to identify the area of ideal implant positioning. The width of the crest at the location of the surgical stent was measured at the time of GBR procedure and 7 to 12 months later during implant insertion. Native collagen sponges were placed buccally and lingually, and a collagen membrane was shaped and trimmed to completely cover the edentulous ridge. The flaps were sutured to achieve primary closure. Antibiotic and clorhexidine mouthrinse were prescribed, and the patients were recalled every 2 weeks. At implant placement, the mean increase in the size of the crest was 2.49 mm (+/- 1.61 mm). In 12 out of 16 patients (75%) it was possible to insert 27 implants according to the prosthetic need established previously. All implants were successfully loaded, and in the four cases where no appreciable results were obtained, no clinical complications or loss of hard and soft tissue were observed.

Adult↗
PubMed1997

Guided tissue regeneration employing a collagen membrane in a human periodontal bone defect: a histologic evaluation.

The purpose of this study is to confirm histologically whether a new attachment can be obtained around a tooth by guided tissue regeneration using bioresorbable barrier. The test tooth was a maxillary molar with an intrabony pocket. At reentry 5 months after periodontal surgery, a hard, whitish, blood-free tissue was found to fill the original defect. Histologic analysis revealed presence of new bone, cementum, and periodontal ligament compatible with the expected histologic result of guided tissue regeneration techniques with barrier membrane.

Absorption↗
PubMed1996

The use of a slowly resorbable collagen barrier in the regeneration of bone in deep wide defects: a case report.

This paper presents a case in which a resorbable collagen membrane and a collagen-based spacemaker and root surface conditioning were used in a guided tissue regeneration procedure. There was no need to disturb the healing potential of the underlying selected cells with an early reentry procedure. Clinical postoperative findings at the time of surgery and in an 18-month follow-up and the differences in density of the mineralized tissues, as detected by standardized series of juxtagingival radiographs and during surgical reentry, showed encouraging results in bone regeneration and soft tissue management.

Adult↗
PubMed1996

Application of slow-resorbing collagen membrane to periodontal and peri-implant guided tissue regeneration.

The utilization of resorbable membranes in the guided tissue regeneration technique allows unquestionable advantages for both the dentist and patient. Collagen is an important constitutive element of the human body and therefore is biodegradable. This study deals with a new slow-resorbing collagen membrane that, when used in conjunction with hydroxyapatite, brings about very interesting results for the treatment of periodontal and peri-implant defects.

Adult↗
PubMed1991

Emerging fractal properties in gorgonian growth forms (Cnidaria: Octocorallia).

Gorgonian growth has been hitherto studied mostly by investigating the influence of different environmental conditions on shape and orientation. We have made an attempt at analyzing the intrinsic growth properties of these organisms, by using a method capable of pointing out a fractal arrangement. Colony outlines of the gorgonian species Eunicella singularis, Eunicella cavolinii, Paramuricea clavata, and Lophogorgia ceratophyta have been digitized and their length measured by traveling along them with a series of logarithmically increasing steps. When this procedure is used on fractal lines, logarithmic plots of estimated length vs. step show linear trends, whose slope yields the fractal dimension. In gorgonian outlines, due to their limited multi-scale organization, we have found curved trends typical of non-fractal lines. However, non-linear regression analysis has shown that the degree of bending is variable from curve to curve, with differences among species. also, in P. clavata and L. ceratophyta there is a positive correlation between the degree of development and the tendency to assume a fractal geometry. This suggests that gorgonian growth mechanisms retain a self-similar design, which becomes evident only in species combining a large size with a high branch density. Based on these data, possibilities of modeling biological patterns through fractal growth models are questioned.

Animals↗
PubMedDate not supplied

Dynamic helical CT of breast tumors.

PURPOSE: The purpose of our study was to test dynamic helical CT (hCT) in the evaluation of breast tumors. METHOD: Thirty-six patients with 39 suspected lesions underwent breast hCT before and 1, 3, and 8 min after intravenous contrast medium administration. A marked enhancement (> or = 100%) at 1 or 3 min without increase at 8 minutes was considered as the primary indicator for malignancy. Twenty carcinomas, one metastatic non-Hodgkin lymphoma, six fibroadenomas, and six other benign findings were histologically assessed. Six cases had negative fine needle aspiration cytology and at least a 2 year negative follow-up. RESULTS: hCT showed a 100% sensitivity and 83.3% specificity. Considering carcinomas and fibroadenomas, significant differences were found for the percent enhancement at 1 min (p = 0.002) as well as for the density increase or decrease at 3 versus 1 min (p = 0.0035), at 8 versus 1 min (p = 0.0027), and at 8 versus 3 min (p = 0.0180). CONCLUSION: hCT proved to have a high diagnostic efficacy in evaluating breast tumors. Even though it involves some exposure to radiation, it should be considered in patients in whom MR is contraindicated.

Adult↗