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Biomedical subjects

R Pant

Publications and source records attributed to R Pant.

At least 19 recordsLinked to original sources
PubMed2005

An unusual case of an intramuscular lipoma of the pectoralis major muscle simulating a malignant breast mass.

INTRODUCTION: Intramuscular lipomas of the pectoralis major muscle are rare and may mimic malignant breast tumours. CLINICAL PICTURE: A 58-year-old Chinese woman presented with a 2- year history of an enlarging left breast mass. Clinical examination revealed a palpable hard mass in the left breast. TREATMENT: Standard mammographic views revealed a radiolucent mass deep in the left pectoralis major muscle. The mass was homogeneously hypoechoic with smooth margins on ultrasound. OUTCOME: Surgical excision of the mass was performed. Histological diagnosis was an intramuscular lipoma of the left pectoralis major muscle. CONCLUSIONS: Recognition of the radiolucent density and submammary location of a pectoralis major muscle lipoma is important as it allows the correct diagnosis to be made.

Breast Neoplasms↗
PubMed2003

The supracondylar femoral nail in tibia.

We have found the intramedullary supracondylar femoral nail to be useful in special situations involving the tibia: proximal tibial fractures and nonunions, intercalary resections for tumors in the proximal or distal tibial diaphysis, and tibio-talo-calcaneal arthrodeses. We report on ten such cases.

Bone Nails↗
PubMed2003

Turn-up bone flap for lengthening the below-knee amputation stump.

When amputation just below the knee becomes necessary after extensive loss of bone from the tibia and of anterior soft tissue in the treatment of tumours, fractures or infection, the remaining proximal tibia may be too short for a below-knee prosthesis, although the knee may be normal. We have included the distal tibia or foot in a long posterior flap by turning it up thus increasing the length of a very short proximal tibial stump. The knee is thereby saved, allowing satisfactory use of a below-knee prosthesis. This technique is particularly applicable when the distal leg is normal and well vascularised. Five procedures have been undertaken. We present two illustrative cases.

Adolescent↗
PubMed2003

Routine abdominal and pelvic ultrasound examinations: an audit comparing radiographers and radiologists.

An audit of 202 routine abdominal and pelvic ultrasound examinations was carried out to evaluate the clinical performance and interpretation of these scans by radiographers and compare them with radiologists, and to investigate the extended role of radiographers in performing these scans. Each scan was first performed by a radiographer and then repeated by the radiologist. The findings were subsequently compared and any discrepancy resolved by re-scanning the patient with or without the involvement of an independent radiologist, or by follow-up of the patient by other imaging studies. In 158 (78.2%) scans, there was complete agreement between the radiographer's and radiologist's findings. In 44 scans (21.8%), there was incomplete agreement--there were 108 abnormal findings in these scans with incomplete agreement/discrepancy in 53 abnormalities. Overall, the accuracy of radiographers was 92.0% and radiologists was 91.7%; however, the accuracy rates were 94.0% and 96.4%, respectively, when minor abnormal findings without significant influence on the patient's clinical outcome were excluded.

Abdomen↗
PubMed2002

Modular megaprosthesis for proximal femoral tumors.

Fifteen patients with proximal femoral tumors had resection and limb salvage with an uncemented Kotz (HMRS) megaprosthesis. There were five osteosarcomas, four chondrosarcomas, one hemangioendothelioma, three fibrosarcomas, and two Ewing's sarcomas. The mean follow-up was 6.7 (range 3-10) years. Two patients died of causes not related to the prosthesis. The postoperative Musculoskeletal Tumor Society score (MSTS) score was 19 (range 12-26) for the remaining 13 patients. There were one aseptic loosening, two infections, and one local recurrence. The most frequent complication was hip dislocation at 20%. Reconstruction of proximal femoral tumors with a modular megaprosthesis is a good procedure, but hip instability remains a major problem.

Adolescent↗
PubMed2001

Pelvic limb-salvage surgery for malignant tumors.

Thirteen patients with primary malignant tumors of the pelvis underwent internal hemipelvectomy. The diagnoses were: Ewing's sarcoma 7, osteosarcoma 4, chondrosarcoma 1, and malignant fibrous histiocytoma 1. No megaprostheses or massive allografts were used for reconstruction. Six patients underwent resection only with no reconstruction, 5 had strut grafts inserted to restore the pelvic ring, 1 had an autoclaved autograft of the acetabulum and 1 had an ilio-femoral arthrodesis. No patients were lost to follow-up. Nine patients died from their disease after an average of 23 months (range 2 to 72 months). The 4 survivors (3 free of disease) have an average follow-up of 84 months (range 60 to 120 months).

Adolescent↗
PubMed2000

Limb salvage for proximal tibial tumours using a modular prosthesis.

We report early results after the resection of proximal tibial tumours followed by reconstruction using a modular prosthesis. The indication for wide resection was a malignant tumour in 13 patients, and a neglected giant cell tumour in 2. There were no mechanical failures during an average follow-up of 3.5 years. However, there were 5 peroneal nerve palsies, 1 complete sciatic nerve palsy, 1 vascular injury leading to an above knee amputation, and 2 deep prosthetic infections. There were 2 superficial skin necroses and 1 fracture proximal to the femoral prosthetic component. The mean post-operative Musculo-Skeletal Tumour Society (MSTS) score in 12 patients who still had their prosthesis in situ was 18.3 out of a possible total of 30 (range: 10-28). Limb salvage surgery in the proximal tibia has a high early complication rate even with the use of modern implants and improved techniques.

Adolescent↗
PubMed2000

Treatment of nonunion around the olecranon fossa of the humerus by intramedullary locked nailing.

Nonunion of fractures of the olecranon fossa of the humerus presents a difficult surgical problem. The distal fragment is usually small and osteoporotic and stable fixation is not easy to achieve. We describe a modification of the technique of locked nailing by which the distal aspect of the nail is placed in the subchondral region of the trochlea. Good results were obtained in seven out of eight patients with this technique.

Adult↗
PubMed1995

Genital burns and vaginal delivery.

Obstetric complications may result from burn scarring in the genital area. Women in developing countries typically squat around cooking fires, and burns are common. This recent case in Nepal describes obstructed labor in a young woman whose genital area had extensive scarring from a cooking fire injury. Proper antenatal assessment by health care providers can reduce the risk to mothers and infants of the consequences of a birth canal damaged or obstructed by burn scarring.

Adolescent↗
PubMed1992

Renal parameters during infancy.

In a prospective study we estimated common renal parameters in 48 full term normal neonates, of which 15 were also tested at 6 months and 12 months of age. The mean levels of serum creatinine, were high at birth (0.73 mg/dl) but normal for age at 6 and 12 months; uric acid followed a similar trend. The blood pH and bicarbonate were low at birth (7.28 and 20.36 mEq/L, respectively) reached normal adult values by 12 months; chloride levels were high at birth (110 +/- 5 mEq/L) and normal at 6 months. The plasma renin activity was higher than normal all throughout the first year (27.1, 416.8, 64.8 ng/ml/hr by RIA). Plasma aldosterone values were high at birth (1387.5 pg/ml) and reached normal level (301.6) at 12 months. Renal length and volume as assessed by ultrasonography compared well with American standards. Urinary constituents were variable due to breast feeding up to 6 months and varied diet during the weaning period. This study shows that mild metabolic acidosis and hyperchloremia due to immaturity of renal acidification mechanism and high renin and aldosterone levels due to partial nonresponsiveness of distal tubules are normal variables in babies from birth to 6 months. The levels of serum creatinine and uric acid are high at birth and in assessing renal functions this should be borne in mind.

Age Factors↗
PubMed1989

Therapeutic action of acetylcholine in malathion toxicity.

Administration of malathion to the developing Philosamia ricini larvae induces accumulation of acetylcholine, marked inhibition of acetylcholinesterase activity, depletion of all nutrients, heavy weight loss and high mortality. Pre-treatment of the larvae with acetylcholine via feed, reduces malathion toxicity and conversely, feeding of acetylcholine to malathion-treated larvae reverses the toxic effects. Resumption of normal control feed to malathion-treated insects results in higher mortality than in insects fed acetylcholine after exposure to malathion. This emphasizes the therapeutic action of acetylcholine. Feeding of a mixture of equal quantities of malathion and acetylcholine recorded significantly lower mortality among insects in comparison to those fed malathion alone. This further supports the protective action of acetylcholine. Reversal of malathion toxicity and the protective action of acetylcholine have been attributed to the mediation of choline, an essential insect vitamin that gets released as a catabolic product of acetylcholine.

Acetylcholine↗
PubMed1978

Is a urea cycle present in insects?

1. The presence of appreciable activity of the urea-cycle enzymes in the tissues of Sarcophaga ruficornis, a carnivorous dipteran insect, all through its life-cycle appears significant in view of their total absence barring arginase (L-arginine ureohydrolase, EC 3.5.3.1) in the phytophagous lepidopteran eri silkwork Philosamia ricini at any stage of development. Further, the variation of all these enzymes all through its development suggests the possibility of the operation of the Krebs-Henseleit urea cycle in this carnivorous insect. 2. The almost parallel behaviour of arginase and ornithine delta-transaminase (L-ornithine-2-oxo acid aminotransferase, EC 2.6.1.13) in both the insects suggests another important role of the former in proline biosynthesis in insects. 3. High proteolytic activity accompanied with significant protein depletion and simultaneous increase in arginine is suggestive of the degradation of proteins and peptides.

Animals↗