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Biomedical subjects

R Palmer

Publications and source records attributed to R Palmer.

At least 163 records · Page 9Linked to original sources
PubMed1980

[A study of the prognosis at one year after restorative tubal surgery in the treatment of sterility (author's transl)].

A cooperative study has been carried out on 301 women who were operated on for tubal sterility in 9 centres in different countries between 1969 and 1974. 19 per cent of these started an intra-uterine pregnancy and 4 per cent an extra-uterine pregnancy during the first year they were followed up. The results reaffirm the poor prognosis of genital tuberculosis, of tubal blocks found on hysterosalpingography and of adhesions discovered on laparoscopy. If the type of operation has little relationship to the results, these do change according to the treatment given around the time of operation. There were more intra-uterine pregnancies in women who had treatment systemically with corticoids and with antibiotics than in those who only had corticotherapy locally. This result has been confirmed when results have been compared taking into account the Centre where the operation was carried out and the type of lesions that were discovered on hysterosalpingography and on laparoscopy.

Adult↗
PubMed1977

[The outlook for gross hydrosalpinx].

Classically, the volume of a hydrosalpinx is taken as an essential factor in working out the prognosis of tubal operations carried out on this kind of lesion. This theory is contradicted following a study of a series of 62 patients who presented with greatly dilated ampullae. Firstly, the percentage of cases that were and could not be operated on during examination was no different in this group than in those where the hydrosalpinx was of a more usual volume. Secondly, at least 12 patients, which means 28 per cent of those who had tubal plastic surgery, had at least one intrauterine pregnancy. The percentage of those with tubal patency if also very satisfactory because it could be restored in more than three-quarters of the cases. Remarkably, in this series there was no ectopic pregnancy. It seems, therefore, that it is time to review the poor reputation of the large hydrosalpinx.

Adnexal Diseases↗
PubMed1976

Total-body sequential segmental irradiation and combination chemotherapy for children with disseminated neuroblastoma.

Fourteen children with disseminated neuroblastoma were treated with segmental total-body irradiation and a combination of cyclophosphamide, vincristine and Adriamycin. Six others had localized tumors and were treated with either surgery alone or limited irradiation and chemotherapy. The main objective of the study was to find out if this aggressive therapy for disseminated neuroblastoma would be tolerated and would promote longer disease-free remissions and possibly, cures. Complete responses were obtained in all patients with localized tumors. Of the 14 patients with disseminated disease, three had complete responses, five had partial responses, two had objective responses, and four were classified as nonresponders. Survival rates for this group are poor. Only two patients are still alive, and the single patient who survives free of disease has had a complex clinical course that is only indirectly a result of treatment. The median survival for patients with disseminated tumor was 9 months, not appreciably different from earlier result. Although toxicity was clinically manageable, it interfered with the planned schedule of therapy. Continuous weight loss combined with severe bone marrow suppression due to irradiation prevented about 50% of the scheduled drug dose from being administered. This resulted in poor control of tumor outside of radiation ports and eventually led to progressive disease within previously irradiated sites. We conclude that irradiation used in this manner will not improve disease-free survival of children with disseminated neuroblastoma. It is essential that disseminated disease be controlled before extensive irradiation is attempted.

Antineoplastic Agents↗