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Biomedical subjects

R PATTERSON

Publications and source records attributed to R PATTERSON.

At least 19 recordsLinked to original sources
PubMed1963

CANINE ANTISERUMS ANALOGOUS TO HUMAN ALLERGIC AND "BLOCKING" ANTISERUMS.

The serums of dogs that are allergic to ragweeed can passively sensitize normal dogs. Cutaneous reactions or systemic anaphylaxis may be produced by appropriate challenge with ragweed extract. Canine antiserum produced by immunization of normal dogs with ragweed extract is shown to inhibit these reactions of the passively sensitized dogs.

Animals↗
PubMed1962

The metabolism of serum proteins in the hen and chick and secretion of serum proteins by the ovary of the hen.

In the chicken, serum gamma globulin (CGG) is preferentially transferred by the follicular epithelium of the ovary to the developing ova. The concentration of gamma globulin in the yolk of the unfertilized egg is many times the concentration of chicken serum albumin (CSA). This transfer occurs largely during the 4 to 5 days preceding ovulation when the growth of the ovum is most rapid. Thus, in the chicken, the follicular epithelium of the ovary serves the same purpose in the passive immunization of offspring as does the acinar epithelium of the udder in ungulates and the extraembryonic membranes in rabbits and man. The amount of gamma globulin synthesis by the chick is low during the first 2 weeks of life and is associated with low levels of serum gamma globulin. By the end of the 1st month of life, the level of serum gamma globulin increases, presumably reflecting an increased rate of synthesis. In the adult hens the half-life of I(131)-labeled CSA is 66 hours and that of I(131)-labeled CGG, 35 hours, while in the newly hatched chick for I(131)-labeled CSA it is 42 hours and for I(131)-labeled CGG, 72 hours. Thus, this species shows a gamma globulin sparing in the first days of life, as do most mammalian species.

Animals↗