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Biomedical subjects

R P Zelt

Publications and source records attributed to R P Zelt.

5 recordsLinked to original sources
PubMed1985

Ascorbic acid therapy in a thermal burn model of corneal ulceration in rabbits.

We studied the effect of topical and systemic ascorbic acid on a rabbit model of corneal ulceration produced by thermal burn. Central stromal ulceration occurred in 77% to 100% of eyes in all treatment groups. The rate of ulceration was accelerated in animals treated with systemic ascorbic acid. Ulceration began after 5.80 +/- 2.14 days in control eyes and 2.75 +/- 1.26 days in the eyes of rabbits treated with both topical and systemic ascorbic acid (P less than .02). Subconjunctival ascorbic acid alone did not affect the rate of ulceration (average onset, 6 +/- 1 days). Once ulceration occurred in animals treated with both topical and systemic ascorbic acid, the incidence of perforation and descemetocele formation was increased and that of healing was decreased. The time required for healing was not significantly altered by treatment (9.50 +/- 2.28 days for control eyes vs 5.75 +/- 2.78 days for treated eyes) (P greater than .05).

Animals↗
PubMed1982

Immunosuppression and selective inflammatory cell depletion. Studies on a guinea pig model of corneal ulceration after ocular alkali burning.

Total ocular-surface alkali burning was performed on guinea pigs to study the effects of generalized immunosuppression and selective inflammatory cell line modifications on corneal ulceration. Central stromal corneal ulceration developed in 86% (18/21) of control eyes three to seven days after alkali burning, whereas ulcers developed in only 16% (3/19) of the eyes of guinea pigs immunosuppressed with cyclophosphamide. Neutrophils, the preponderant inflammatory cells in ulcerating corneas, were conspicuously absent from the nonulcerating corneas. Selective neutrophil suppression by intravenous administration of a highly specific anti-guinea pig neutrophil serum also suppressed the development of corneal ulcerations in this model; in only 25% of the eyes so treated did ulcers develop after alkali burning. T lymphocyte or monocyte modifications with similar monospecific antisera had no effects on the rate of corneal ulceration. Neutrophil depletion after the onset of ulceration halted progression of the corneal ulcer.

Animals↗
PubMed1980

Clinical tear analysis using laser diffraction.

A diagnostic method has been developed to analyze tear specimens from patients with red eyes, using the technique of laser diffraction. After proper tear sample preparation, presence of a diffraction halo produced by the tear specimen indicates presence of an external ocular inflammation and helps rule out such conditions as glaucoma, iritis and episcleritis. Measurement of the size of the halo pattern may also be used to give information as to the concentration of cells in the tear sample.

Conjunctivitis↗
PubMedDate not supplied

Congenital seesaw nystagmus.

A 14-year-old boy with congenital seesaw and horizontal pendular nystagmus associated with decreased visual acuity, high myopia, esotropia, and normal peripheral visual fields is reported. Neurologic and computed tomographic evaluation, as well as auditory evoked potentials, were normal. The findings in, and recommended evaluation of, seesaw nystagmus in young patients are reviewed.

Adolescent↗