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Biomedical subjects

R P Wenzel

Publications and source records attributed to R P Wenzel.

At least 145 records · Page 8Linked to original sources
PubMed1992

Methods for estimating days of hospitalization due to nosocomial infections.

While there is little agreement at the individual patient level of analysis, estimates of mean NI-attributed days of stay for the two methods were essentially the same. The lack of agreement at the individual patient level may reflect fundamental differences in the methods used to derive these estimates: incorporation of noninfected patient data versus exclusive reliance on data from infected patients; and, focus on length of stay rather than the actual care being received. The potential advantages of the AEP-based method include the following: 1) all patients with NI can be included in developing estimates; 2) estimates are based on the care provided rather than simple length of stay differences; 3) data on which to form the NI-day estimates are readily available in the medical record; 4) the AEP is a validated and commonly used utilization review instrument; 5) the AEP-based method has acceptable reliability; 6) this method is designed to provide individual and group estimates of NI-attributed days; 7) because every day of stay is reviewed, additional information is available, which results in greater precision of study of the development, diagnosis, and treatment of the NI relative to the other care that originally brought the patient into the hospital. The AEP-based method for estimating NI-days is a promising alternative to the historical cohort approach. Additional applications of this approach are encouraged to further assess its reliability,validity, and additional information yield.

Cohort Studies↗
PubMed1992

In vitro activity of decaplanin (M86-1410), a new glycopeptide antibiotic.

The in vitro activity of decaplanin (formerly M86-1410), a novel glycopeptide antimicrobial agent, was tested against 169 gram-positive bloodstream isolates from patients at the University of Iowa Hospitals and Clinics and 12 selected vancomycin-resistant strains. Enterococcus faecalis, E. faecium, Staphylococcus aureus, streptococci, bacilli, corynebacteria, and listeria were inhibited by decaplanin (MICs for 90% of the strains tested [MIC90s], 0.12 to 4 micrograms/ml). However, some rarely isolated and selected Enterococcus sp. populations had a MIC90 of 16 micrograms/ml, and S. haemolyticus strains had a MIC90 of 8 micrograms/ml. These in vitro results suggest that decaplanin may be useful against most gram-positive strains, even though some Enterococcus species and coagulase-negative staphylococci were potentially resistant (MICs, greater than or equal to 8 micrograms/ml).

Ampicillin↗
PubMed1992

The clinical impact of culturing central venous catheters. A prospective study.

The semiquantitative culture technique is a standard procedure for the laboratory diagnosis of catheter-associated infections and catheter-associated bacteremia. In a prospective observational study, we evaluated the clinical impact of the semiquantitative culture results on the treatment of the patient. Clinical impact was defined as a change in diagnosis or therapy on the basis of the semiquantitative culture result. One hundred fifty-seven catheters consecutively submitted from the surgical intensive care unit to the laboratory were studied. In 96% of the episodes, no clinical impact was observed. In the other 4%, clinical decisions were guided mainly by the concurrent positive blood cultures. Newer laboratory techniques that do not require removal of the catheter are needed to guide therapeutic decisions.

Anti-Bacterial Agents↗
PubMed1991

Infection control: the premier quality assessment program in United States hospitals.

The three decennial international meetings of the Centers for Disease Control have reaffirmed the national health priority for prevention of nosocomial infections. Moreover, the past 20 years have seen the institutionalization of the infection control practitioner and hospital epidemiologist. The epidemiologic activities of these two groups have included access to medical care, identification of risk factors, and both prevention and control of adverse nosocomial events. As such, they represent experience with issues commonly referred to as quality of care. It is argued that infection control not only is now but has been from its inception the premier quality assessment program in the United States. Moreover, it is the only activity in quality assessment that has been shown to be efficacious.

Cross Infection↗
PubMed1991

Methicillin-resistant Staphylococcus aureus: implications for the 1990s and effective control measures.

Data from around the world verify the escalating incidence of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Since MRSA are spread primarily on the hands of health care workers, rates of infection are a function of infection control activities within institutions. Moreover, infections with MRSA are serious and often life-threatening. Thus, there are compelling medical and ethical reasons to invest in control measures. Currently available data suggest the efficacy of three measures: (a) identification of the entire patient reservoir (cases and carriers) for purposes of isolation; (b) strict handwashing between patients to prevent transmission; and (c) treatment of the carrier state in health care workers and patients during periods of high infection rates with safe and effective topical agents such as mupirocin.

Carrier State↗
PubMed1991

A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group.

OBJECTIVE: To assess the efficacy of adjunctive monoclonal antibody antiendotoxin immunotherapy in patients with gram-negative sepsis. DESIGN: Double-blind, randomized, placebo-controlled trial. SETTING: Thirty-three university-affiliated centers, including Veterans Affairs, community, and municipal hospitals. PATIENTS: Hospitalized adults with signs of gram-negative infection and a systemic septic response. INTERVENTION: Patients were assigned to receive either 2 mg/kg of a murine monoclonal antibody directed against gram-negative endotoxin (E5) or placebo. A second infusion was administered 24 hours later. MAIN OUTCOME MEASURES: Mortality over the 30-day study period, resolution of organ failures, and safety. RESULTS: Four hundred eighty-six patients were enrolled. Three hundred sixteen had confirmed gram-negative sepsis (54% bacteremic, 46% nonbacteremic). The survival difference was not statistically significant for all patients. Among patients with gram-negative sepsis who were not in shock at study entry (n = 137), E5 treatment resulted in significantly greater survival (relative risk, 2.3; P = .01). Resolution of individual organ failures was more frequent among these patients, occurring in 19 (54%) of 35 patients in the E5 group vs eight (30%) of 27 in the placebo group (P = .05). Four reversible allergic reactions occurred among 247 patients (1.6%) receiving E5. No other toxicity was identified. CONCLUSIONS: Treatment with E5 antiendotoxin antibody appears safe. It reduces mortality and enhances the resolution of organ failure among patients with gram-negative sepsis who are not in shock when treated.

Aged↗
PubMed1991

Elimination of coincident Staphylococcus aureus nasal and hand carriage with intranasal application of mupirocin calcium ointment.

OBJECTIVE: To determine the safety and efficacy of mupirocin calcium ointment in the elimination of Staphylococcus aureus nasal and hand carriage in healthy persons. DESIGN: A double-blind, placebo-controlled, randomized trial. SETTING: Clinical research unit of a tertiary medical center. SUBJECTS: Health care workers with stable S. aureus nasal carriage. INTERVENTIONS: Subjects (n = 68) were randomly assigned to receive either mupirocin or placebo intranasally twice daily for 5 days. MEASUREMENTS AND MAIN RESULTS: Cultures of the hands and nares were obtained at baseline and 72 hours after therapy. The nares were also cultured 1, 2, 4, and 12 weeks after therapy. Antimicrobial susceptibility testing and restriction endonuclease analysis of plasmid DNA were used to confirm strain identity. There were no serious side effects. Mupirocin decreased the frequency of S. aureus nasal carriage at each time interval: At 3 months, 71% of subjects receiving mupirocin remained free of nasal S. aureus compared with 18% of controls. This difference (53%; 95% CI; 26% to 80%) was significant (P less than 0.0001). Additionally, analysis of plasmid patterns showed that 79% of subjects in the mupirocin group were free of the initial colonizing strain at 3 months. The proportion of hand cultures positive for S. aureus in the mupirocin group after therapy was lower than in the placebo group (2.9% compared with 57.6%). This difference (53%; 95 CI, 30% to 80%) was significant, after adjustment for the frequency of hand carriage at baseline (P less than 0.0001). CONCLUSIONS: When applied intranasally for 5 days, mupirocin calcium ointment is safe and effective in eliminating S. aureus nasal carriage in healthy persons for up to 3 months and appears to have a corresponding effect on hand carriage at 72 hours after therapy.

Administration, Intranasal↗
PubMed1991

Feasible and desirable future targets for reducing the costs of hospital infections.

The authors propose that there are, in general, five methods to reduce the costs of hospital infection: reduce the incidence, reduce the morbidity causing prolonged illness, reduce hospital stay, reduce the costs of currently effective preventive and control measures, and stop all ineffective measures. The feasible and desirable components of these methods are described.

Communicable Disease Control↗
PubMed1991

The continuing importance of staphylococci as major hospital pathogens.

Rates of hospital-acquired staphylococcal infection have risen substantially in the United States over the last decade. Moreover, it has been shown that bloodstream infections caused by these organisms account for significant morbidity and mortality. It is likely that the changes in medical practice and in types of patient account for these changes, and current antibiotic therapy has helped select more resistant organisms. The increasing use of implantable and temporary medical devices and the increased use of immunosuppressive therapies correlate strongly with the rising incidence of these organisms. Likewise, more patients are predisposed to these infections because of poor immune status and factors favouring colonization. Intrinsic microbiological factors such as glycocalyx production and the presence of bacterial surface proteins allow these organisms to adhere to protein coated foreign bodies and basement membranes thus enabling them to initiate infection and cause disease. Moreover, virulence factors such as encapsulation, slime production and elaboration of extracellular enzymes aid their resistance to host defences. As a group, staphylococci are a leading cause of hospital-acquired infection, and species identification is required for both treatment and control.

Bacterial Proteins↗
PubMed1991

Handwashing: efficacy versus acceptance. A brief essay.

The efficacy of handwashing for preventing transmission of infections in the hospital is well accepted. Nevertheless, compliance by health care workers is estimated at approximately 40%. Based on observations of effective behavioural changes in other areas of public health, the authors suggest that hospital epidemiologists consider testing the use of both social pressures and marketing techniques to influence current handwashing practices in hospitals.

Consumer Behavior↗