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Biomedical subjects

R P Spark

Publications and source records attributed to R P Spark.

29 records · Page 2Linked to original sources
PubMed1981

Does transplacental spread of coccidioidomycosis occur? Report of a neonatal fatality and review of the literature.

A neonatal death due to unsuspected coccidioidomycosis was studied. A critical review of the 12 neonatal fatalities and two survivals now reported strongly opposes the concept of transplacental spread. Associated with 35 maternal fatalities in the literature are 16 cases of placentitis and five neonatal deaths; none of the neonatal deaths, however, were associated with placentitis. Three of these five had predominantly intrathoracic disease, as did those neonates whose rapid deaths were unassociated with maternal coccidioidomycosis. Transpartum aspiration of infected decidua or postpartum inhalation is the probable initial pathogenic event in neonatal coccidioidomycosis.

Coccidioidomycosis↗
PubMed1979

Pseudogonococcal ophthalmia neonatorum. Branhamella (Neisseria) catarrhalis conjunctivitis.

A culture from conjunctivitis occurring in a neonate in association with a recurrent fever yielded a nearly pure growth of Branhamella (Neisseria) catarrhalis. The conjunctivitis was not appreciated and effectively treated until a second hospitalization in the fourth week of life. Partial suppression of symptoms had followed short-term parenteral antibiotic therapy during the first admission. Resolution quickly occurred in response to instillation of sodium sulfacetamide ophthalmic solution. Although B. catarrhalis is considered a non-pathogen, the literature reviewed included a number of diverse infections, but no previous instance of conjunctivitis. The organism's close similarities to Neisseria gonorrhoeae necessitate isolation and correct biochemical differentiation. Misdiagnosis of gonococcal conjunctivitis carries obvious social, psychological and medical impact.

Conjunctivitis↗
PubMed1976

Filiform polyposis of the colon. First report in a case of transmural colitis (Crohn's disease).

Filiform polyposis of the colon is characterized by multitudinous wormlike projections of mucosa and submucosa, and it has only previously been reported to be an unusual sequel to a prior limited episode of ulcerative colitis. The first reported instance complicating a 16-year course of typical transmural colitis (Crohn's disease) suggests that this benign proliferation may be a nonspecific submucosal response to two separated, but closely subadjacent zones of submucosal inflammation in either type of colitis. Although few cases of filiform polyposis are available for review, there has been no instance associated with carcinoma. The entity in itself does not represent an indication for colectomy.

Adult↗
PubMedDate not supplied

Necrotizing sialometaplasia. A self-limited pseudotumoral palatal ulcer.

Necrotizing sialometaplasia of the palate, an enigmatic pseudomalignant penetrating ulcer, is a benign lesion which heals spontaneously in three to ten weeks. Relative painlessness contributes to patient delay in seeking medical attention, and suggest that many cases are subclinical. Clinically, the patient age group and morbid gross appearance mimic malignant palatal tumors. Lack of awareness of this entity has led to the misdiagnosis of carcinoma in several previous cases. However, the histopathologic features of sialadenitis, focal lobular necrosis with mucosal ulceration and glandular squamous metaplasia, are distinctly benign. A typical case and literature review are presented.

Adult↗
PubMedDate not supplied

Vibrio alginolyticus wound infection: case report and review.

Vibrio alginolyticus was associated with a littoral wound infection in an Arizonan injured near the Sea of Cortez. While this is the first instance from this estuary, the relatively recent increase in the number of isolates suggests both that most coastal waters are a natural habitat of the organism and that probably many previous isolates were incorrectly identified in the past. Mischaracterization most likely results from a gram-negative work-up routine deficient for the isolation of halophilic organisms. The morbid course of this case was in part predictable owing to the organism's resistance to several first choice antibiotics. The laboratory characteristics of V. alginolyticus and others in the Vibrio genus associated with maritime disease are reviewed.

Adult↗