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Biomedical subjects

R Ovcharov

Publications and source records attributed to R Ovcharov.

46 records · Page 3Linked to original sources
PubMed1973

[Hexobarbital sleep in rats treated with polyvinylpyrrolidone].

Young male rats, breed Wistar, underwent daily intravenous injections with 10 ml per kilogram body weight polyvinyl pyrrolidone, over a period of five days. As a control group, non injected rats of the same age were used. The duration of sleep after interaperitoneal injection of hexobarbital natrium at dose 100 mg/kg weight was checked in both groups. It was established that in the animals treated with polyvinyl pyrrolidone the duration of sleep was shorter. In a second group of animals, treated with polyvinyl pyrrolidone, the concentration of aminopyrine N-demethylase in the liver was traced.

Aminopyrine N-Demethylase↗
PubMedDate not supplied

[Importance of endogenous opioids and prostaglandins in the action of analgin (metamizole) and verapamil].

The effects of a non-narcotic analgetic methamizole and the calcium channel blocker verapamil on carrageenan hyperalgesia, release of beta-endorphin and synthesis of prostaglandin E2 (PGE2) were studied. It was found that a combined administration of analgin and verapamil prolonged the analgesic effect. Analgin stimulated release of beta-endorphin with the maximum coinciding in time with the peak of the analgesic effect. Against the background of the action of calcium ionophore A 23187 the combination of analgin with verapamil inhibited PGE2 synthesis more distinctly. The combination of these pharmacological agents is suggested to exert the effect both at different levels, central and peripheral, and on various cellular mechanisms involved in pain modulation.

Aminopyrine↗