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Biomedical subjects

R Ottenjann

Publications and source records attributed to R Ottenjann.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Therapy and prevention of reflux esophagitis. Results of a multicenter study with cimetidine. I: Epidemiology and results of acute therapy].

In a sequential observational study efficacy and safety of two dosage regimens of cimetidine for the treatment of reflux-oesophagitis (RE) were examined. 22 office-based specialists took part in the trial. 187 patients received 1600 mg cimetidine (400 mg q.i.d.) daily and 136 patients received 800 mg cimetidine (400 mg b.i.d.) daily, over twelve weeks. The two dosages proved to be equally effective. In the group of patients with RE of stage I at the beginning of the trial, the healing rates were 82% under 1600 mg cimetidine/die and 86% under 800 mg cimetidine/die. In the group of those patients, who entered the study with RE of stage II, in both dosage groups the lesions of 87% of the patients were healed completely or had decreased to stage I. The severity of the mucosal lesions was judged endoscopically, based on a classification scheme modified according to Savary and Miller. The incidence of unwanted symptoms was not significantly different in both dosage groups (1600 mg: 5.3%, 800 mg: 3.4%); none of the symptoms which occurred was judged as definitely caused by cimetidine. The patient collective of the trial was characterized epidemiologically; out of the risk factors examined, only duration of RE history and number of previous RE episodes correlated with the severity of the disease, smoking and alcohol consumption showed no influence.

Adolescent↗
PubMed1986

New unusual forms of colitis. Report of four cases with known and unknown etiology.

Four patients with colitis, in two of whom the etiology was unknown, are presented. One patient with discontinuous segmental colitis was infected by Aeromonas hydrophila, and another with presumed idiopathic inflammatory bowel disease was superinfected by this pathogen. Although Aeromonas hydrophila has been known as a rare cause of diarrhea in our region, it is in the first instance reported to cause severe long-lasting colitis as well as superinfection of idiopathic inflammatory bowel disease (IIBD). Another patient presented with segmental ischemic colitis which was rather atypical and of unknown etiology; the patient was young and had no predisposing factors for vascular occlusive disease. The fourth patient with long-lasting segmental granulomatous colitis which was suspected to be parasitic in origin remained without a definitive diagnosis. This presentation of patients with endoscopically proven colitis should in view of our increasing knowledge of colitis remind us to keep a look out for new infections and other forms of inflammatory bowel disease.

Adult↗
PubMed1986

Antral mucosa heterotopy in the duodenal bulb.

A case of heterotopic antral mucosa presenting as a typical gastric fold, located in the duodenal bulb, is described. Heterotopic gastric mucosa consisting mainly of fundic-type epithelium is commonly found in the gastrointestinal tract and predominantly in the cervical esophagus and the duodenal bulb. Heterotopic gastric mucosa composed of antral-type epithelium, especially of the size described here, is an extremely rare condition. A knowledge of these lesions is clinically relevant in the differential diagnosis at endoscopy of the upper tract.

Aged↗
PubMed1985

[Multiple colorectal polyps and risk of cancer].

The malignancy rate ("severe cellular atypia' and "invasive carcinoma' in adenomas and associated carcinoma) was determined in a retrospective study on 95 patients, aged 28 to 97 years (median age 65 years), with colonoscopy findings showing multiple (more than 8) colorectal polyps. It amounted to 22% to 100% in patients with 8 and up to more than 50 polyps in the colorectum. The malignancy rate was "only' 3.7% to 11.8% based on the number of polyps in the individual patients and thus was about the same as in patients with an isolated or few polyps. Thus, malignancy rate increases with number of polyps (by far the majority adenomas). Endoscopy showed the presence of gastric polyps in eleven of the 95 patients (11.6%) with multiple colorectal polyps. With the exception of one "borderline lesion' they were benign, showing no definite tendency towards malignancy. After endoscopic ectomy of the multiple polyps surgical treatment (procto-mucosectomy, segment resection, hemicolectomy or colectomy) was necessary in 37 patients (39%).

Adenoma↗
PubMed1985

Ergotamine-induced colitis.

We report on a 45-year-old woman with ulcerative colitis of the rectum that arose after the use of up to 6 suppositories of a preparation containing ergotamine daily over a period of 6 years. On the basis of a review of the literature the clinical, endoscopic and histological features of the ergotamine-induced colitis are characterized.

Colitis, Ulcerative↗
PubMed1985

Angiodysplasia in the colon and rectum. Endoscopic morphology, localisation and frequency.

In a prospective study, the occurrence of angiodysplasia was investigated by total colonoscopy in 1938 patients. Angiodysplasia was found in 59 patients, i.e. 3%. 12 out of 59 patients were admitted for acute or chronic peranal hemorrhage or anemia. 47 out of 59 patients were asymptomatic. The site of the lesions was as follows: cecum 37%, ascending colon 17%, transverse colon 7%, descending colon 7%, sigmoid colon 18% and rectum 14%. Histological confirmation was obtained in 15 out of 37 biopsies. The endoscopic appearance was variable, most of the vascular dilatations being smaller than 5 mm (n = 47), with a homogeneous (n = 35) or inhomogeneous (n = 24) structure and a regular (n = 34) or irregular (n = 25) border. The lesions were single (n = 34) as well as multiple (n = 25), they were usually flat (n = 54), seldom slightly prominent (n = 5). Concomitant pathological findings in the bowel were diagnosed in 33 out of 59 patients: diverticula in 32%, adenomas in 24% and carcinomas in 8.5%. Right hemicolectomy for bleeding angiodysplasia is indicated only if endoscopic therapy has failed and other colorectal sources of bleeding, and especially angiodysplasia in the left colon and rectum have been excluded by endoscopy or angiography.

Adolescent↗
PubMed1985

Non-Hodgkin lymphoma of the rectum mimicking angioma.

We report on a 52-year-old man who was admitted to hospital for peranal bleeding due to a rectal tumor with the endoscopic aspect of an angioma. The histological work-up revealed a Non-Hodgkin lymphoma of low malignancy (centroblastic-centrocytic lymphoma in the Kiel classification). The lymphoma was staged IE. A short review of the literature is given.

Biopsy↗
PubMed1985

Famotidine versus ranitidine for the short-term treatment of duodenal ulcer.

One-hundred and eight-three patients with endoscopically proven duodenal ulcers, enrolled in this prospective, double-blind study, were randomly allocated to receive famotidine 40 mg once at night, 20 mg twice daily, 40 mg twice daily, or ranitidine 150 mg twice daily for 2-8 weeks. Pretreatment characteristics between the four groups were similar. After 4 weeks of treatment, among the famotidine-treated patients, 38 of 42 (90.5%) healed with the 40 mg once nightly regimen, 35 of 42 (83.3%) with 20 mg twice daily, and 37 of 41 (90.2%) with 40 mg twice daily. In the ranitidine group 40 of 43 patients (93.0%) healed. After 8 weeks of treatment, the respective data were: 97.6, 95.2, 100 and 93.0%. Different results between the famotidine groups and the ranitidine group were not statistically significant. All treatments were well tolerated and severe adverse events were rare. Famotidine 40 mg given once at night appears to be as safe and effective as conventional therapy with ranitidine, indicating the importance of overnight gastric acidity in the pathogenesis of duodenal ulcer disease.

Adolescent↗
PubMed1985

Treatment of relapsing bleeding peptic ulcers with the somatostatin analogue SMS 201 995 in a patient with Zollinger-Ellison syndrome.

SMS 201-995 is an octapeptide analogue of natural somatostatin characterized by pharmacological properties similar to those of somatostatin itself. In addition, its serum half-life of about 60 minutes after i.v. injection is significantly longer than that of the natural compound. A patient with active bleeding from a peptic ulcer jejuni due to a Zollinger-Ellison syndrome was successfully treated with SMS 201-995. Bleeding stopped after continuous infusion (25 micrograms/h) within the first 24 hours of infusion. The serum gastrin concentration dropped from 3,300 pg/ml to 170 pg/ ml (normal range 40-100 pg/ml). Continuation of the treatment by subcutaneous injections of SMS 201-995 (100 micrograms twice daily) maintained serum gastrin concentrations between 300 to 400 pg/ml over a period of 8 months. Side effects have not been observed. Four subsequent endoscopic examinations have revealed no ulcer relapse.

Humans↗
PubMed1985

[Famotidine versus ranitidine in the acute treatment of duodenal ulcer. A multicenter comparative study in Germany].

185 patients with endoscopically proven duodenal ulcers were randomly allocated to treatment with either famotidine 40 mg nocte, 20 mg bid, 40 mg bid or ranitidine 150 mg bid for 2-8 weeks in a prospective double-blind study. The four groups were similar with regard to age, sex, duration of ulcer disease, smoking habits etc. After 2 weeks treatment 28/42 patients (66.7%) healed on famotidine 40 mg nocte, 24/42 patients (57.1%) on famotidine 20 mg bid, 26/41 patients (63.4%) on famotidine 40 mg bid and 28/43 patients (65,1%) on ranitidine 150 mg bid. The corresponding healing rates after 4 weeks were 90.5%, 83.3%, 90.2% and 93%, respectively. After 8 weeks more than 93% of the patients had healed ulcers. At each time there was no statistical difference between the different famotidine regimens and the ranitidine group. All treatments were well tolerated and severe adverse events were rare. Famotidine 40 mg at night, therefore, appears to be as good as conventional ranitidine.

Adolescent↗