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Biomedical subjects

R Osuch-Jaczewska

Publications and source records attributed to R Osuch-Jaczewska.

At least 19 recordsLinked to original sources
PubMed2001

Comparative study of neutrophil activities in adults and full-term neonates in relation to the method of delivery.

The aim of this study was to compare the markers of neutrophil activity in healthy adults with those in healthy neonates in relation to the method of delivery. The following parameters were studied: absolute neutrophil count, neutrophil adherence to nylon fiber, NBT reduction, and neutrophil phagocytosis of latex particles. The study has shown that the method of delivery significantly affects the markers of neutrophil activity measured in umbilical cord blood. The levels of these markers were higher in neonates born by elective cesarean section than in adults, neonates born vaginally or those born by emergency cesarean section. This comparative study of defensive functions of neutrophils from adults and neonates indicates that the conflicting results of other studies may be caused not only by differences in investigative methodology but also by the fact that the eligibility criteria used in these studies did not include the method of delivery, which can affect the markers of neutrophil activity via triggering a stress response.

Adult↗
PubMed2001

[Potter sequence in a neonate with bilateral renal dysplasia with genetic aspects].

The authors describe a neonate with Potter sequence due to bilateral renal dysplasia and discuss its genetic implications. Although this congenital anomaly of the kidneys may occur sporadically, it is now accepted that this condition has an autosomal dominant inheritance pattern with a penetrance of 50-90% and variable expression. Potter sequence is not compatible with extrauterine life; therefore, in case of maternal oligohydramnios, ultrasound should be performed in the second trimester in order to make a prenatal diagnosis, as well as to permit genetic counseling. As Potter sequence is frequently associated with clinically silent anomalies of the kidneys, ultrasound examination of the kidneys and urinary tract should also be performed in all family members.

Abnormalities, Multiple↗
PubMed2001

[Para/endocrine function of the vascular endothelium of healthy pregnant women and pregnant women with preeclampsia and their neonates].

UNLABELLED: Abnormal endocrine/paracrine function of the vascular endothelium seems to be of most important in the pathogenesis of preeclampsia. The present study aimed to assess plasma concentration of ET-1 and NOx in maternal (M) and umbilical cord blood (UC) in 15 pregnant women with moderately severe preeclampsia (gestosis index 6.1 +/- 0.4), 15 pregnant women with mild preeclampsia (gestosis index 2.3 +/- 0.1) and in 31 healthy pregnant women (in 15 of them elective cesarean section was done). The control group consisted of 10 nonpregnant healthy women (NC). Moderately severe preeclampsia was characterised by a normal or even reduced plasma ET-1 level in maternal (0.7 +/- 0.1 pg/ml and cord blood (1.3 +/- 0.2 pg/ml) but markedly elevated NOx concentration (maternal blood 36.7 +/- 4.2 mumol/l), cord blood 33.5 +/- 3.5 mmol/l). In pregnant women with mild preeclampsia elevated ET-1 levels were found both in cord (3.41 +/- 0.6 pg/ml) and maternal blood (2.62 +/- 0.5 pg/ml) which were accompanied by elevated NOx concentrations (31.2 +/- 2.9 mumol/l and 32.4 +/- 2.3 mumol/l in cord and maternal blood respectively). A significant negative correlation was found between plasma ET-1 and NO levels in cord blood from severely preeclamptic women, but a positive one between cord plasma ET-1 level and gestosis index. CONCLUSION: Participation of altered ET-1 and NOx levels in maternal and cord blood from preeclamptic women as compensatory mechanisms providing adequate perfusion of the utero-placental unit is likely.

Endocrine Glands↗
PubMed1992

[Pregnancy, labor risk factors and neonatal mortality].

In 173 newborns dying at the Neonatology Department, Silesian Medical Academy in Katowice the risk factors connected with pregnancy and labour were analysed. The method used was analysis of onsterric cards and history of newborn development. In 67.3% of cases the newborns were born after complicated pregnancy and 39.9% after complicated labour.

Adult↗
PubMed1992

[Evaluation of glucose and cholesterol levels in the mother and newborn infant in the perinatal period].

In 30 live born newborns the connections were assessed between glucose and cholesterol levels in umbilical cord blood after birth, and also in maternal blood before and two days after birth. Statistically significant differences of glucose and cholesterol levels were found between mothers and newborns in the perinatal period. Attention is called to greater independence of cholesterol (total, free and esterified) levels in newborn and mother in perinatal period.

Adult↗
PubMed1989

[Aldolase activity and the lactate level in the cord blood as objective indicators of the status of newborn infants by the Apgar score].

In 63 newborns with general clinical status evaluated by means of the Apgar score the lactate level and aldolase activity were determined in cord blood. A greatly raised mean level of both these biochemical indicators of tissue hypoxia was demonstrated in newborns with low Apgar score. A considerable scatter of the determined biochemical parameters was noted in newborns born in serious condition and having identical low Apgar score.

Apgar Score↗
PubMed1988

Intranasal LH-RH analogue treatment of precocious puberty.

The agonistic analogues of luteinizing hormone releasing hormone were used in the treatment of precocious puberty (pp) in children. 12 children with pp were treated for 6 months with an intranasal LH-RH analogue (C6-C3-C2-naphtyl/D-alanine)-LHRH. The majority of the children had central precocious puberty. Only one child had peripheral pp. Laboratory assessment of estradiol, testosterone, LH and FSH levels revealed that 1,000 micrograms/day of this analogue diminished the hormone levels only in the group of children with central and combined pp. Bone age, pelvic ultrasound examination, sexual development and growth rate were determined pre-, during and after the treatment. The growth velocity decreased and gonadal and sexual characteristic ceased advancing after the LH-RH therapy. Biochemical and hematological studies performed in our children did not show any significant changes during the treatment periods. No adverse effects were noted from the intranasal therapy. We conclude, that intranasal therapy is safe, convenient and effective in pp, but not of peripheral origin.

Administration, Intranasal↗