Biomedical subjects
R Orme
Publications and source records attributed to R Orme.
'Aneurysm' of nephrostomy catheter complicating extracorporeal shock-wave lithotripsy.
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Case of the month. In what's my line?
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A novel dosage approach for evaluation of SMANCS [poly-(styrene-co-maleyl-half-n-butylate) - neocarzinostatin] in the treatment of primary hepatocellular carcinoma.
We report a Phase I/II clinical trial of poly-(styrene-co-maleyl-half-n-butylate)-neocarzinostatin (SMANCS) for intra-arterial treatment of hepatoma. Early patients received 4 or 8 mg SMANCS dissolved in Lipiodol; later patients were treated according to tumour size and degree of filling achieved. SMANCS/Lipiodol drained rapidly from normal liver but was retained within tumour interstitium. Tumour nodules filled with SMANCS/Lipiodol usually stabilised and often regressed. No UICC criteria-defined responses were achieved, partly due to difficulties of filling several lesions simultaneously. Signs of therapeutic activity suggest a more extensive clinical study is warranted.
Abnormality rates on barium meal examination in different racial groups.
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Imposed upper airway obstruction in small children.
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Perforation of bowel in newborn as complication of exchange transfusion.
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