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Biomedical subjects

R Oriol

Publications and source records attributed to R Oriol.

208 records · Page 12Linked to original sources
PubMedDate not supplied

ABO tissue antigens of Egyptian mummies.

ABO groups were investigated on skin (and muscle), bone and hair specimens from 14 Egyptian mummies dating from the Roman period. Samples were tested by the AE (absorption-elution), MA (mixed agglutination) and HIF (histo-immunofluorescence) methods, in order to evaluate the reliability of each method. For half of the mummies (7) the results were concordant on all samples (3-9 samples for each mummy) with all employed methods, suggesting an unequivocal blood group conclusion. For the other seven mummies there were discordant results with the different methods and interpretation of the results was thus inconclusive. HIF seems to be the most reliable method as specific blood group substances are identified on specific histologic structures. Failure to detect tissular ABO antigens was mainly due to excessive resin impregnation.

ABO Blood-Group System↗
PubMedDate not supplied

Genetic control of the fucosylation of ABH precursor chains. Evidence for new epistatic interactions in different cells and tissues.

The general structure of the ABH antigens is analysed taking into account six possible precursor chains and two alpha-2-fucosyltransferases. The classical genetic model with one structural gene and two regulatory genes for the synthesis of the H antigen and the events which prompted the proposal of the new model with two structural genes for the synthesis of H determinants are discussed. Three human alpha-3-fucosyltransferases with different acceptor specificity are presented. Myeloid type of alpha-3-fucosyltransferase, which transfers fucose on to H type 2, serum type of alpha-3-fucosyltransferase, which transfers fucose on to H type 2 and sialyl-N-acetyl-lactosamine and Lewis or alpha-3/4-fucosyltransferase, which transfers fucose on to H type 1 and H type 2 and the corresponding sialylated structures. The presence of different ABH and Lewis antigens in different tissues and the different epistatic interactions needed to account for their synthesis are analysed in terms of new epistatic interactions with either the known fucosyltransferases or with new fucosyltransferases.

ABO Blood-Group System↗
PubMedDate not supplied

Ultrastructural localization of H human-blood-group immunoreactivity rat cochlear hair cells.

Human blood-group antigens are transiently expressed in developing cochlear hair cells. This temporal antigen expression seems to correspond to the main events of inner ear differentiation (e.g. hair cell development, synaptogenesis, ciliogenesis). In the present report, the cochlear expression of H human blood group antigen has been analyzed with the aid of the electron microscope. Ultrastructurally, cochleas stained with anti-H antibody exhibited an intense immunoreactivity on the apical hair cell membrane and on stereocilia. Cell surface glycoconjugates may serve a large number of functions and could be important during cell development. The temporal expression of H blood-group antigen in developing cochlear hair cells could be related to stereocilia differentiation.

ABO Blood-Group System↗
PubMedDate not supplied

[Polymorphic secretory antigens (WZ) of the human adult and fetal colon].

The present paper concerns further data about the WZ polymorphic antigens of the human colon. A population study conducted with the immunofluorescence technique on rectal biopsies from 150 subjects, confirmed the frequency of the three phenotypes : W+Z (0.65), W-Z+ (0;25), W-Z- (0.10). The same three phenotypes were observed with the immunofluorescence technique in the colon goblet cells of 20 foetuses ranging in ages from 20 to 36 weeks. In these foetuses a comparative study of the WZ and ABH antigens along the length of the gastrointestinal tract showed the same reverse distribution of the two kinds of antigens as previusly reported in the adult. The comparison of the inhibition activity of adult or foetal colon mucosa extracts in a radioimmunoassay test showed that the WZ antigens are similarly present in heated water, phenolalcohol, and perchloric acid extracts. The WZ antigens are present in the meconium.

Colon↗