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Biomedical subjects

R Olinescu

Publications and source records attributed to R Olinescu.

38 records · Page 3Linked to original sources
PubMedDate not supplied

The influence of "selenium organicum" upon the hepatic function of carbon tetrachloride poisoned rats.

The hepatoprotective action of the Romanian preparation Orgasel containing selenium (Se) 5.01 mg/100 g autolysated yeast powder, was tested on adult Wistar rats poisoned with carbon tetrachloride (CCl4). The hepatotoxic agent (a 20% CCl4 solution in oil) was administered i.p. in a single dose of 0.3 ml CCl4 solution/100 g body weight, and the preparation tested (autolysate of seleniated yeast) was administered by gavage in 4 doses (of 100 mg Se powder/100 g animal each) along 2 days. After 48 hrs the animals were sacrificed, then their blood and liver were collected. The treatment with Orgasel significantly reduced the organs, morphological changes (fat liver degeneration, splenomegaly, testicle degeneration) induced by CCl4 poisoning in the rat, an effect found also at the biological parameters levels studied in plasma and liver. In the plasma, the high lipid peroxide concentrations, the increased activity of alkaline phosphatases, and the reduced antioxidative activity generated by CCl4 have been statistically significant brought to the normal range after Orgasel administration. At the liver this treatment significantly decreased the lipid peroxides production, the total lipids and cholesterol concentrations, and statistically significant increased the enzymes activity (alkaline phosphatases, GPT). The results obtained after Orgasel administration proved that this preparation has a global beneficial action upon the organism in the poisoned rat, as well as a strong antioxidative effect, confirming once again the essential role of Se in maintaining cells' integrity.

Animals↗
PubMedDate not supplied

Comparative study of the presence of oxidative stress in sportsmen in competition and aged people, as well as the preventive effect of selenium administration.

The study demonstrates the presence of oxidative stress (OS) in physiological conditions in sportsmen in competition and in elderly subjects over 65 years. The OS was estimated by measuring some biochemical parameters, such as peroxides, total antioxidants, uric acid and free SH groups in plasma and peroxides in urine. OS produces a significant increase of peroxides in plasma and urine and a decrease of plasma antioxidants and SH groups. The presence of OS suggests an increased formation of free radicals in young subjects in sporting competition, This increase is subsequently compensated by an increase of antioxidants. In old agers, this unbalance remains unchanged. The level of OS is higher in sportsmen during competition, but the subsequent compensation depends on the degree of training, individual adaptation, diet, etc. The administration of organic selenium partially compensates and decreases the intensity of OS. This study confirmed the hypothesis that in old agers the formation of free radicals increases in the ageing process and recommends the prevention of OS in young sportsmen by an adequate protection with antioxidants, such as organic selenium.

Adult↗