Contact with phenylketonurics and their families beyond pediatric age: conclusion from a survey and conference.
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Biomedical subjects
Publications and source records attributed to R O Fisch.
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Perinatal and medical information, growth, and the social background of 258 children who, in a prospective study, had superior intelligence at 7 years of age were reviewed. The subjects were divided into three categories on the basis of the results of psychological evaluation at age 7. Comparisons were made between those with superior (intelligence quotient greater than or equal to 120), average (IQ between 80 and 119), and low intelligence (IQ less than or equal to 79). A favorable parental social and educational background was the best correlate of superior intelligence in the children. Larger head size from 1 year of age was an early finding associated with superior intelligence. Greater height and weight, from 4 years of age were later findings. Correlations between psychological performance at ages 4 and 7 years were statistically significant. Perinatal factors and medical complications did not affect the intellectual status of children with superior intelligence.
Perinatal, growth, social, and psychologic data, collected through seven years of age on 144 adopted children and on 288 matched controls as part of a prospective study of 3,120 children, were subjected to statistical analysis. Only single births and healthy children were included. The adopted subjects were divided into two groups: 94 children who were adopted by nonrelatives (77 prior to one year of age and 17 after one year of age); and 50 children who remained with their biologic mothers and were subsequently adopted by stepfathers. Children who were adopted prior to one year of age had significantly higher IQs at four years of age then did their controls; at seven years of age, however, their IQs were similar even though the adopted children were raised in a higher socioeconomic environment. The adopted children had better academic achievement and were taller at four and seven years of age than were the controls. The performance of the children adopted after one year of age, even though they were raised in a higher socioeconomic environment, were, were like those of their controls at both four and seven years of age. The performance of the children who remained with their biologic mothers was similar to that of their controls. Maternal intelligence generally did not correlate well with adopted children's intelligence; however, a specific significant positive correlation could be shown between maternal intelligence and the intelligence of children who remained with their biologic mothers.
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Fifty-eight survivors of the respiratory distress syndrome were evaluated at age 4 years for deficits in neuromotor performance and physical growth in a prospective study. Comparisons between RDS survivors and 290 matched controls plus 35,198 unmatched controls demonstrated that for each group the neuromotor performance was adversely affected by either low birth weight or low socioeconomic standing. Except for infants with birth weights above 2.5 kg, the RDS survivors performed as well as the two control groups. Comparisons with siblings failed to reveal a decrement in the RDS survivors. Hypothyroidism was more frequent among the RDS survivors than among the control subjects in the highest category of birth weight.
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Prospectively collected data concerning a large group of children were analyzed to determine whether extremes of body habitus at birth were predictive of obesity and leanness at 4 and 7 years of age. A ratio of weight to height (ratio index) was used to determine relative fatness. Neonates who were extremely lean (0 to 5th percentile) or extremely obese (95th to 100th percentile) showed a tendency to persist, albeit at a decreasing rate, in their original habitus at 4 and 7 years of age. This tendency was slightly more marked in the extremely lean than it was in the extremely obese children at 4 and 7 years of age. Children who were extremely lean or obese at 4 years of age seldom abandon that status by 7 years of age. Similarly, most children at the extremes of body habitus at 7 years of age had already attained that status by 4 years of age. In addition to these postnatal trends, a positive correlation was found between the maternal ratio index and pregnancy weight gain, on the one hand, and the ratio index of the children in the extreme categories at each age, on the other.
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