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Biomedical subjects

R Noyes

Publications and source records attributed to R Noyes.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Analgesic effect of delta-9-tetrahydrocannabinol.

A preliminary trial of oral delta-9-tetrahydrocannabinol (THC) demonstrated an analgesic effect of the drug in patients experiencing cancer pain. Placebo and 5, 10, 15, and 20 mg THC were administered double blind to ten patients. Pain relief significantly superior to placebo was demonstrated at high dose levels (15 and 20 mg). At these levels, substantial sedation and mental clouding were reported.

Administration, Oral↗
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Cannabis analgesia.

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Adult↗
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The occurrence of a prodrome of generalized anxiety in panic disorder.

Twenty-eight percent of 32 panic disordered patients had a prodrome of generalized anxiety symptoms lasting a median of 5 years before the occurrence of their first panic attack. Patients with a generalized anxiety prodrome were similar to the nonprodrome patients for 55 tested clinical variables, including individual anxiety symptoms, response to treatment, severity of illness, and most aspects of family history. It appears that a prodrome of generalized anxiety symptoms is a variation of the presentation of panic disorder. Initially, these patients may be misdiagnosed as having generalized anxiety disorder (GAD) and contribute to the heterogeneity of GAD.

Adult↗
PubMedDate not supplied

Predictors of serious suicide attempts among patients with panic disorder.

Of 74 panic disorder subjects followed up after 7 years, five reported serious suicide attempts and three had completed suicide. Compared with subjects who had not made serious attempts, the serious suicide attempters (including the three suicides) were younger, and fewer of them were married. Also, the serious attempt group had an earlier, more gradual onset of illness. More of the serious attempters had personality disorders and coexisting major depression. At the time of original assessment, the serious attempters had more severe symptoms. These data suggest that among patients with panic disorder, serious suicidal behavior is associated with more severe psychopathology.

Adult↗
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Examination of comorbid anxiety in psychiatric inpatients.

Seventy-three percent of 90 psychiatric inpatients had a coexisting anxiety disorder. There were few differences between patients with or without coexisting anxiety on more than 100 clinical and demographic variables that were tested. Patients who had an anxiety syndrome before the onset of their major psychiatric disorder also showed few differences when compared with patients whose anxiety started coincident to or after another DSM-III axis I disorder. The concept of primary/secondary anxiety disorder may not be useful when applied to a cross-section of psychiatric inpatients.

Adult↗
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Personality traits associated with panic disorder: change associated with treatment.

Eighty-two subjects with panic disorder completed the Personality Diagnostic Questionnaire (PDQ) before treatment and again after a period of relatively stable improvement 3 years later. At baseline, panic subjects scored higher than normal control subjects, who had been matched for age and sex, on avoidant, dependent, histrionic, and paranoid personality subscales. Improvement in panic symptoms after 3 years was associated with reductions in these same subscale scores. Examination of individual items that distinguished panic from normal subjects showed themes of dependency, lack of self-confidence, emotional instability, and sensitivity to criticism that reflected demoralization in the panic disorder subjects. To a large extent, the findings reveal nonspecific, state-dependent effects of panic and agoraphobic symptoms on the personality functioning and morale of patients with panic disorder.

Alprazolam↗
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Compulsive behaviors and obsessive-compulsive disorder (OCD): lack of a relationship between OCD, eating disorders, and gambling.

The lifetime prevalence of eating disorders and pathologic gambling was assessed in first-degree relatives of subjects with obsessive-compulsive disorder (OCD) and well controls. There were no significant differences between the groups. The authors conclude that eating disorder and pathologic gambling have no familial relationship to OCD.

Adolescent↗
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Personality disorder traits in generalized anxiety and panic disorder patients.

Eight-four panic disorder (PD) and 29 generalized anxiety disorder (GAD) patients were compared with respect to abnormal personality traits assessed by a structured interview (Structured Interview for DSM-III Personality [SIDP]) and a self-report inventory (Personality Diagnostic Questionnaire [PDQ]). An earlier study using many of the same patients by Noyes et al. found PD patients to have more extensive axis I psychopathology than GAD patients. However, in this study it was the GAD patients who appeared to have greater axis II pathology. In particular, when using a subset of patients who had been matched for age and gender, the GAD patients reported more antisocial traits. This finding is particularly interesting, since the matched samples consisted primarily of women in their forties and fifties.

Adult↗
PubMedDate not supplied

Comparison of major depressive patients with a predominantly sad versus anxious mood.

One hundred and seventy-seven patients with major depressive disorder (MDD) experienced a mood disturbance that could be characterized as predominantly sad (55%), anxious (31%) or mixed (14%). Patients that had a predominantly sad mood were more likely to be hypersomnic, anhedonic, younger and seen in an outpatient setting. Predominantly anxious MDD patients were more likely to have been hospitalized, agitated, psychotic, incapacitated, insomnic, and to have had higher post-dexamethasone cortisol levels.

Adult↗