Search PubMed⌕ Search

Biomedical subjects

R Noto

Publications and source records attributed to R Noto.

At least 37 records · Page 2Linked to original sources
PubMed1988

Hypercalcemia in childhood renal tumors.

Hypercalcemia is an uncommon complication of childhood renal tumors. It is exclusively seen in infants 6 months of age or younger with malignant rhabdoid tumor of the kidney (MRTK) or congenital mesoblastic nephroma (CMN). Secretion of parathormone or prostaglandin E2 by the tumor cells is responsible for the hypercalcemia in most of these patients. Bone metastasis has been notably absent in these patients, and the hypercalcemia completely resolves with the removal of the tumor. Hypercalcemia in itself probably does not have any prognostic significance; however, it may serve as a tumor marker in some patients. Early recognition and effective management of this complication may prevent the acute life-threatening as well as the longstanding complications of this serious metabolic disorder.

Female↗
PubMed1988

Prolactin and thyroid status in prepubertal children with mild to moderate obesity.

Prolactin (PRL) response to thyrotropin releasing hormone (TRH) in 21 prepubertal children with mild to moderate obesity was compared with that in 21 normal prepubertal children (controls). Basal PRL levels were normal but the mean peak PRL response and mean increment in PRL levels following TRH administration were significantly lower in prepubertal obese children (p less than 0.001). The mean PRL responses to TRH were significantly impaired at all time intervals in prepubertal obese boys and girls compared to the control subjects. Linear regression and correlation coefficient analysis did not reveal any significant relation between the percent overweight and PRL response. Basal T4, T3 levels and T3 and TSH response to TRH were similar in both groups. The findings suggest that neuroendocrine regulation of prolactin is impaired in prepubertal children even with mild to moderate obesity. This could be secondary to altered neurotransmitter status at the hypothalamic level. Further studies are needed to determine whether the defect is innate or acquired, primary or secondary.

Child↗
PubMed1976

[Laryngo-tracheal injuries in hangings (apropos of 359 cases)].

Hanging is a relatively frequent method of suicide, and strangulation (accidental or volontary) may cause direct laryngeal or tracheal trauma and various lesions which may express themselves clinically either: -early, was severe from the start, e.g. fracture of the larynx, with major ventilatory distress, -or delayed, simple trauma without fracture, becoming manifest only after a few hours with severe dyspnea. In any case, early and late complications of these traumas require, even when they are apparently benign, admission to hospital on a specialised unit able to carry out rapidly respiratory intensive care.

Edema↗