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Biomedical subjects

R Nissen

Publications and source records attributed to R Nissen.

At least 37 records · Page 2Linked to original sources
PubMed1978

Increased turnover of arterial collagen in hypertensive rats.

The turnover of total collagen in several tissues of 12-week-old normotensive and hypertensive rats was estimated by using tritium-labeled proline as a precursor. The effect of reutilization of the label was minimized by treatment with large doses of unlabeled proline subsequent to administering the radioactive imino acid. The collagen from skin, tail tendon, aorta, and mesenteric artery in normotensive animals had a half-life of about 60--70 days. In hypertensive animals the half-lives of skin and tail tendon collagen were unchanged but the half-lives of collagen in the aorta and mesenteric artery were reduced to 17 days.

Animals↗
PubMed1977

[Peptidyl prolyl hydroxylase activity in relation to the actual collagen biosynthesis in cotton pellet granuloma of guinea pig (author's transl)].

During the different stages of granuloma formation peptidyl prolyl hydroxylase activity and neutral salt soluble collagen were determined in the granuloma tissue. In parallel peptidyl prolyl hydroxylase activity, "collagen-like protein", and free hydroxyproline were measured in the serum of the same animals at correspondant time distances. A close correlation was found between the enzyme activity and the other parameters of collagen synthesis. These results confirm the conclusion that hydroxylation of polypeptide may be a rate limiting step in collagen biosynthesis. In addition the investigations revealed a close correlation between enzyme activity in the tissue and enzyme activity in the serum.

Animals↗
PubMed1977

[20 years in the management of reflux disease using fundoplication].

During the past twenty years fundoplication has found widespread propagation. Due to its effectiveness it is today the most often applied operative procedure of reflux-preventing surgery. As such the method must be reserved for clearly demonstrated reflux disease and its organic complications. False indication and incorrect technique have burdened results of such operations with unnecessary complications. The steps to a successful surgical reconstruction of the cardia are thus shown. In the future, the results of this surgical method will have to be improved more by correct indication instead of changing the surgical technique.

Esophagitis, Peptic↗