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Biomedical subjects

R Nikolova

Publications and source records attributed to R Nikolova.

12 recordsLinked to original sources
PubMed1998

[Invasive fungal infection in malignant hematologic diseases].

In patients with hematological malignancies invasive mycoses occur frequently. In this retrospective study autopsy and histopathology material of 171 patients with hematological malignancy who had died between 1994 and 1996 at the 1st Department of Internal Medicine (Hematology), St. László Hospital, Budapest was analysed. In cases with invasive fungal infection post mortem results were compared to clinical and microbiological data. Through the three years' period an invasive mycosis could be confirmed in 33 patients by autopsy. Aspergillosis occurred in 21, candidiasis in 11, other fungal infections in 2 cases, a double infection was seen in 1 patient. The incidence was 19.2% (in invasive candidiasis: 6.4%, in aspergillosis 12.2%). Invasive aspergillosis most frequently was seen in the lung (71%), while candidiasis occurred mainly in the intestinal tract (42%). Cultures for mycology were collected from the autopsy material of 9 patients, of which 8 gave positive results. A previous fungal colonisation results was confirmed in 23 patients, but based on colonisation conclusions rarely could be driven concerning the species causing invasive infection. Sensitivity of Aspergillus antigen and antibody tests was 45 and 50%, respectively. Predisposing factors for invasive aspergillosis and candidiasis were similar, except for duration of neutropenia (24 vs. 12 days, p < 0.004). The antifungal drug most frequently used was amphotericin B. We observed a persisting infection in invasive pulmonary aspergillosis and chronic disseminated candidiasis in spite of the administration of a cumulative dosis of 1-2 g. Most frequently Aspergillus infections--primarily that of the lung--can be seen. Presence of invasive mycoses can usually be confirmed in vivo, but an early diagnosis still remains unsolved.

Aspergillosis↗
PubMed1997

Relationship between heart rate variability and hypercholesterolaemia.

A statistically significant correlation between chronic (tonic) distress (expressed by long-term depression of heart rate variability-HRV) and the increase of the serum lipid level was found in the experimental group (39 clinically healthy subjects with hypercholesterolaemia; 16 women and 23 men; mean age 42.4 +/- 2.45 years). A statistically significant relationship was found also between the experimental and control group (39 healthy normocholesterolaemic subjects; 18 women and 21 men; mean age 43.7 +/- 2.18 years) when comparing distress indicating HRV-based measurements. Significant predictors of HRV depression were: total cholesterol and low-density lipoprotein cholesterol. The effect of a 3-month special diet served to 17 subjects selected from the experimental group led to a decrease of serum lipids but did not influence substantially HRV parameters. It can be concluded that HRV parameters reflecting stress reaction correlate with atherogenic serum lipids; their separate follow-up (which is quicker, easier and cheaper) can be used for prediction of cardiovascular health risk and probably for disorders in serum lipid metabolism.

Adult↗
PubMed1996

[Purulent meningitis in an adult patient caused by multi-drug resistant Streptococcus pneumoniae 19A].

UNLABELLED: This is the first report in Hungary about meningitis caused by multiply-resistant Streptococcus pneumoniae in a 54 year old woman. The Streptococcus pneumoniae serotype 19A was highly resistant to penicillin, ampicillin, chloramphenicol, cefuroxime and intermediate resistant to ceftriaxone. The antibiotic treatment was started with penicillin and ampicillin. The antibiotic treatment was changed to vancomycin + ceftriaxone, vancomycin + rifampicin and vancomycin + imipenem on the 2nd, 4th and 11th hospital days, respectively. She died on the 29th day with symptoms of sepsis. Necropsy and microscopic examination of the brain revealed localised inspissed layer of purulent exsudat over the convexities. Under this area the small wessels and capillaries were thrombotic and were surrounded by severe degeneration and necrosis in the white matter. RECOMMENDATIONS: Streptococcus pneumoniae has to be considered penicillin resistant until the organism is proved to be susceptible to penicillin. The authors advise the administration of dexamethasone, based on their own favourable 7 years experience.

Anti-Inflammatory Agents↗
PubMed1996

Functional brain asymmetry, handedness and age characteristics of climacterium in women.

A total of 1985 women aged between 55 and 65 were distributed into two groups (145 left-handers and 1840 right-handers). They were asked to complete a questionnaire on the appearance of menopause, duration of menopausal transition and age of menopause. In left-handed women a significantly earlier appearance of premenopause was established together with a shorter menopause transition and an earlier occurrence of menopause. These results give grounds for a correlation between handedness, functional brain asymmetry, respectively and the genetically determined fading away of ovary steroidogenesis associated with the appearance and progression of the climacterium. In light of the available literature we assume that progressive reduction in ovarian function during climacterium is coupled with possible specific functioning of the hypothalamo-pituitary-gonadal axis, dependent on the type of hemispheric asymmetry.

Aged↗
PubMed1995

[Age-related transfer coefficients of the basic indices of cardiac variance].

This study was concerned with the relationship of changes in cardiac variance to age. A total of 518 subjects were involved. The following indicators of ACV (analysis of cardiac variance) were investigated: mean--mean value of successive cardiac intervals, SD--standard deviation of mean value of cardiac intervals (R-R), AMo--amplitude of the mode, HI--homeostatic index, Pt--spectral power of R-R related to thermoregulation, Pr--spectral power of R-R related to respiration, IBO--index of centralization. For each one of these ACV indicators, a mathematical expression of its relationship to age was specified. The coefficients obtained from the indicated expressions of the relationship "age-to-ACV indicators" represent transfer coefficients for the particular measured quantities. Their methodological importance lies in the fact that through them it becomes possible to make age corrections of ACV indicator figures for the purpose of comparing individual subjects or groups of subjects. These coefficients help to establish nomograms for the particular age ranges.

Adult↗
PubMed1995

[Changes in the status of the adaptation of workers at the television relay station on top of Botev Peak].

The state of adaptation of subjects (numbering 17) occupied at Botev Peak TV relay station and thereby exposed to nonionizing radiations--electromagnetic fields (EMF)--was monitored by following changes in analysis of cardiac variance (ACV) indicators. In addition to these, other physiologic indicators studied were systolic and diastolic blood pressure, as well as psychologic indicators, notably, psychosomatic complaints as early manifestations of disturbance in the state of adaptation. Data from the group of subjects studied were compared to those of a control group whose working conditions involved no EMF exposure. This comparison, based on ACV indicators (mean--mean value of successive cardiac intervals, SD--standard deviation of mean value of cardiac intervals (R-R), AMo--amplitude of the mode, SI, ABI, HI--homeostatic index, CP--classification parameter, IC), psychosomatic complaints, systolic and diastolic blood pressure, provided no evidence of reduction of adaptive reserves or deterioration of somatic and mental health state in occupationally exposed workers at Botev Peak TV relay station.

Adaptation, Physiological↗
PubMed1995

[The correlations between psychological indices and cardiac variance].

Correlative links between psychologic and psychologic indicators were studied in subjects occupied either in airline transportation or in the chemical industry. Investigations covered three groups of persons: managers of airline traffic (57 subjects); workers at "Vratsa" Chemical plant (14 subjects); and operators at "Vratsa" Chemical plant (14 subjects). The psychologic parameters measured included indicators of cardiac variance: mean--mean value of successive cardiac intervals, SD--standard deviation of mean value of cardiac intervals (R-R), AMo--amplitude of the mode, HI--homeostatic index, Pt--spectral power of R-R related to thermoregulation, Pp--spectral power of R-R related to respiration, IBO--index of centralization; psychologic parameters included: extrovertiveness, introvertiveness, neuroticism, psychoticism, interpersonality conflicts, self-control, social support, self-confidence, work satisfaction, psychosomatic complaints. There was evidence of significant and highly significant correlative links between indicators of cardiac variance and psychologic indicators. There thus appeared to exist certain relationships between the psychologic and psychologic levels during lengthy stressful occupational exposure.

Adult↗
PubMed1992

[The assessment of the general functional status and of the psychosomatic complaints of workers at hydroelectric power plants].

Evaluation of the general functional status and psychosomatic complaints of 61 workers from the hydroelectric power stations is made. The following methods are used: 1. Assessment of the general functional state, by means of computer analysis of the cardiac variability, analysing the changes in the values of the following indices: average value of the cardiac intervals (X), their standard deviation (SD), coefficient of variation (CV), amplitude of the mode (AMO), index of stress (IS), index of the vegetative balance (IVB), homeostatic index (HI). The last 3 indices serve for determination of the complex evaluation of chronic fatigue and work adaptation (ChFWA). 2. Evaluation of the psychosomatic complaints, by the use of a questionnaire for the subjective psychosomatic complaints. 3. Studying the systolic and diastolic blood pressure. The average values received in workers from HPS were compared with the average values of the population of the country and with the average values of a similar working activity of a group of operators from the thermal power station HPS. In conclusion it could be noted that concerning ChFWA the received values in workers from HPS are not more unfavourable generalized values from that measured in workers, occupied with similar type of work in other industrial branches of the country. However, they are with more unfavourable data in comparison with the workers from HPS. The subjective evaluation of the operators concerning their psychic and body health status is moderately worse, both in comparison with the values of the index for the country, and in comparison with those of the operators from HPS.

Bulgaria↗
PubMed1991

[An assessment of the information value of the indices from analyzing cardiac variability (ACV)in situations related to neuro-emotional stress].

A group of 67 students in medicine, sitting for an examination on obstetric and gynaecology, were subject to examinations in the periods: before and immediately after the examination. Taking into consideration the analysis of the heart variability (AHV), the pre-examination period shows more strongly expressed stress component, the main constituent of which is the sense of fear. Between the performance and the changes in the indices of the analysis of the heart variability, reflecting the total functional state, fatigue and distress, no specific differences were discovered. The sexual differences were expressed only in the way that the stress discomfort in women dies out more slowly than in men. A conclusion is made, that the pulse frequency and the indices of the analysis of the heart variability, related to the variability, including the combined index - CI, reflect more clearly the induced by the examination model emotional discomfort, than the indices, obtained from the frequency spectrum of the heart rhythm (Czechoslovakia).

Adult↗
PubMedDate not supplied

Processing compounds: A cross-linguistic study.

This study explores the role of semantic transparency and morphological headedness in the on-line visual recognition of French and Bulgarian compounds using a constituent repetition priming paradigm. The results reported show significant constituent priming effects for both languages. Moreover, distinct priming patterns emerged, demonstrating that the semantic transparency of individual constituents, their position in the string, and morphological headedness interact in the processing of compounds.

Adult↗