Does an endogenous methylpyridinium analogue cause Parkinson's disease?
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
Biomedical subjects
R Naylor
Publications and source records attributed to R Naylor.
Detecting the early stages of osteomalacia with the intravenous vitamin D test.
Studies of calcium levels in 400 elderly patients in a hospital geriatric unit showed that many patients (42 percent) had hypocalcemia when referred to the unit and that the incidence of hypocalcemia rises proportionately with advancing age; however, in men, the frequency decreases after age 90. Although hypocalcemia is caused by vitamin D deficiency in a number of patients, in most it is caused by malnutrition. The intravenous vitamin D tests is a simple and reliable procedure for differentiating hypocalcemia due to specific vitamin D deficiency from that due to other causes. We suggest that a 15 percent rise in the serum phosphate level after the intravenous administration of 40,000 units of vitamin D3 indicates the presenceof osteomalacia. Little is known about the sequence of development of detectable bone changes and disturbance of serum calcium, phosphate, and alkaline phosphatase levels in the natural course of osteomalacia. Early treatment of osteomalacia is simple and very rewarding. No effort should be spared in detecting it as soon as possible.
Aged↗
Pulmonary function study in old age.
A study was carried out in 100 patients aged between 70 and 90 years to investigate pathological and respiratory function changes in old age. Vitalograph and peak flow meter measurements were made, but blood gas analysis was only carried out in 6 patients in view of the technical difficulties. Analysis of the results showed that there was a definite, moderate, restrictive type of defect in pulmonary function in almost all the patients, in those with generalized senile changes as well as in those with a pathological condition. Blood gas analysis showed a minimum degree of alteration in oxygen tension and saturation with normal carbon dioxide tension.
Aged↗
The objective measurement of mental performance in cerebrovascular disease. A double-blind controlled study, using a graded-release preparation of isoxsuprine.
An automatically controlled learned task was used to assess objectively the mental performance of a number of geriatric patients with cerebrovascular disease. The effect on the performance of the patients during treatment with isoxsuprine hydrochloride in a sustained-release presentation ("Duvadilan Retard") was measured during a double-blind, placebo-controlled trial of sixteen weeks' duration. There was a significant difference in the improvement in performance between the treated and untreated groups; by the end of the trial, the treated group having statistically significantly better scores (P = 0.047 two-tailed tests).
Aged↗
Improved large-volume sampler for the collection of bacterial cells from aerosol.
A modified large-volume sampler was demonstrated to be an efficient device for the collection of mono-disperse aerosols of rhodamine B and poly-disperse aerosols of bacterial cells. Absolute efficiency for collection of rhodamine B varied from 100% with 5-mum particles to about 70% with 0.5-mum particles. The sampler concentrated the particles from 950 liters of air into a flow of between 1 and 2 ml of collecting fluid per min. Spores of Bacillus subtilis var. niger were collected at an efficiency of about 82% compared to the collection in the standard AGI-30 sampler. In the most desirable collecting fluids tested, aerosolized cells of Serratia marcescens, Escherichia coli, and Aerobacter aerogenes were collected at comparative efficiencies of approximately 90, 80, and 90%, respectively. The modified sampler has practical application in the study of aerosol transmission of respiratory pathogens.
Aerosols↗