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Biomedical subjects

R Nath

Publications and source records attributed to R Nath.

At least 235 records · Page 13Linked to original sources
PubMed1982

Effect of chronic cadmium treatment on the ascorbic acid status of the rat.

In rats chronically treated with varying doses of cadmium (Cd) (0.25, 0.50, 0.75 and 1.0 mg/kg body wt.), i.p., every alternate day for 7 weeks, a decrease in the ascorbic acid (AA) content of adrenals and liver was observed. In the adrenals AA depletion was significant and dose-dependent at all concentrations. In liver the decrease was significant only at a concentration of 0.75 and 1.00 mg/kg but the spleen did not show any change in AA content. Urinary excretion of beta2-microglobulin with increasing doses of Cd indicated progressive renal tubular damage. The decrease in tissue AA status was correlated with the severity of the renal tubular damage resulting in an inhibition of its reabsorption from the kidneys.

Adrenal Glands↗
PubMed1982

Vitamin B6 deficiency as related to oxalate-synthesizing enzymes in growing rats.

Chronic vitamin B6 deficiency in male rats, 1, 2 and 3 months of age, led to increases in the activities of liver glycolate oxidase and kidney glycolate dehydrogenase as compared to pair-fed controls. Lactate dehydrogenase activity either decreased or showed no change in all three age groups. It is postulated that hyperoxaluria observed in vitamin B6 deficiency is due to two different pathways operative in the liver and kidney separately. A general increase seen in the enzyme activities of livers and kidneys of B6-deficient and pair-fed rats was age related.

Alcohol Oxidoreductases↗
PubMed1982

Effect of vitamin B6 and B1 deficiencies on the intestinal uptake of calcium, zinc and cadmium.

A chronic vitamin B6 deficiency in rats resulted in a non-specific increase (44- 51%) in the in vitro intestinal uptake of both essential (Ca and Zn) and non-essential toxic metal (Cd) ions, whereas an acute B6-deficient state only affected the Zn uptake rate. In vitamin B1-deficient animals, a specific decrease (30-32%) was observed in Ca and Zn uptake with a 59% increase in the intestinal uptake of Cd. These altered metal ion uptake rates were probably not a result of hormonal disturbances due to the vitamin-deficient states.

Animals↗
PubMed1982

Effect of pyridoxine supplementation on recurrent stone formers.

Twelve recurrent stone formers with hyperoxaluria were administered pyridoxine-HCl (10 mg/day) daily for a period of 180 days. The pyridoxine status of the patients, as assessed by their erythrocyte transaminase activation indexes, improved significantly (p less than 0.001) after 180 days of supplementation as compared with the basal levels. Although urinary oxalate decreased significantly (p less than 0.05) by the 90th day of pyridoxine therapy, other parameters, e.g., urinary calcium, phosphorus, and creatinine, remained unaltered. Significant correlation was observed between erythrocyte glutamate pyruvate transaminase (EGPT) or erythrocyte glutamate oxaloacetate transaminase (EGOT) activation index and urinary oxalate excretion (p less than 0.01). Pyridoxine in low doses (10 mg/day) is of therapeutic value for hyperoxaluric stone formers.

Adult↗
PubMed1980

Response of mammalian cells irradiated with 30 MV X-rays in the presence of a uniform 20-kilogauss magnetic field.

The effects of intense magnetic fields on the survival curves for aerated and hypoxic Chinese hamster lung cells exposed to 30 MV X-rays were investigated. A uniform 20-kilogauss magnetic field, as well as a non-uniform magnetic field with an average value of 17 . 5 kilogauss and a gradient of 2 . 3 kilogauss/cm, were employed. A study of the repair of sublethal damage for cells exposed to the magnetic field only during the split-dose irradiations, and the effect of exposure to the magnetic field alone for 2 hours, were also studied. For each of these four experiments, no effects attributable to the magnetic field were detected.

Animals↗