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Biomedical subjects

R Natarajan

Publications and source records attributed to R Natarajan.

At least 145 records · Page 8Linked to original sources

Distribution of Vibrio parahaemolyticus in finfish harvested from Porto Novo (S. India) environs: a seasonal study.

A seasonal survey was undertaken to elucidate the incidence of Vibrio parahaemolyticus in freshly caught and market samples of fish collected from five distinct locales near Porto Novo. Vibrio parahaemolyticus was isolated from 35.6 and 40.6% of freshly harvested fishes from the estuary and mangroves, respectively, while only 3.9% of freshly caught specimens originating from the Bay of Bengal were positive for the pathogen. Isolation rates of 46.8% for fishes from the landing site and 40.6% for fishes from the fish market were recorded. Vibrio parahaemolyticus was more readily recovered from market samples of fish (44%) compared with freshly caught brackish water fishes (37.5%). Incidence of V. parahaemolyticus was higher during summer (March-July) than in other seasons.

Animals↗

Meibomian gland carcinoma initially identified by cytology.

A 60-year-old female presented with a growing tumor of her left upper eyelid of 6 mo duration. The fine-needle aspiration cytology (FNAC) report was consistent with the clinical diagnosis of meibomian gland carcinoma, which was subsequently confirmed by histopathologic examination of tumor tissue. Exenteration was performed following a course of radiotherapy. There was no sign of recurrence after a follow-up period of 6 mo.

Carcinoma↗

QSPR modeling for solubility of fullerene (C(60)) in organic solvents.

Solubility of fullerene C(60) in 75 organic solvents was examined to develop quantitative structure-solubility relationships. Topological indices and polarizability parameter computed from refractive index were used to form the regression models. The models suggested for individual data sets such as alkanes, alkyl halides, alcohols, cycloalkanes, alkylbenzenes, and aryl halides have good predictive ability and are better than the models for the combined groups. Inclusion of an indicator parameter which is a combination of atom contributions and contributions of substituents' position in benzenes improved the predictive ability significantly.

Journal Article↗

QSAR modeling of flotation collectors using principal components extracted from topological indices.

Several topological indices were calculated for substituted-cupferrons that were tested as collectors for the froth flotation of uranium. The principal component analysis (PCA) was used for data reduction. Seven principal components (PC) were found to account for 98.6% of the variance among the computed indices. The principal components thus extracted were used in stepwise regression analyses to construct regression models for the prediction of separation efficiencies (Es) of the collectors. A two-parameter model with a correlation coefficient of 0.889 and a three-parameter model with a correlation coefficient of 0.913 were formed. PCs were found to be better than partition coefficient to form regression equations, and inclusion of an electronic parameter such as Hammett sigma or quantum mechanically derived electronic charges on the chelating atoms did not improve the correlation coefficient significantly. The method was extended to model the separation efficiencies of mercaptobenzothiazoles (MBT) and aminothiophenols (ATP) used in the flotation of lead and zinc ores, respectively. Five principal components were found to explain 99% of the data variability in each series. A three-parameter equation with correlation coefficient of 0.985 and a two-parameter equation with correlation coefficient of 0.926 were obtained for MBT and ATP, respectively. The amenability of separation efficiencies of chelating collectors to QSAR modeling using PCs based on topological indices might lead to the selection of collectors for synthesis and testing from a virtual database.

Journal Article↗