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Biomedical subjects

R Natangelo

Publications and source records attributed to R Natangelo.

29 records · Page 2Linked to original sources
PubMedDate not supplied

Significance of circulating C1q-binding activity in chronic liver disease: a study of 133 cases.

Circulating immune complexes (CIC) were measured in 133 biopsy-proven patients with various liver diseases. The correlation between CIC levels and other laboratory findings was investigated in each disease group, in order to assess if the increased C1q-binding activity found in these patients was related to particular features of the disease. CIC levels were not significantly different in HBsAg-positive and HBsAg-negative patients. No correlation was found between CIC levels and serum bilirubin, AST, ALT and C3 levels. A negative correlation with C4 levels and a positive correlation with immunoglobulin levels were found in the majority of the patients, while prothrombin time and albumin levels were negatively correlated to CIC levels only in patients with chronic active hepatitis. Increased CIC levels could represent a response to gut-associated antigens, a passive accumulation due to reduced hepatic function or both.

Alanine Transaminase↗
PubMedDate not supplied

Procollagen-type III peptide serum concentrations in alcoholic and non-alcoholic liver disease.

The type III procollagen aminopeptide (sPIIIP) serum levels were measured in 197 patients with liver disease and were correlated with morphological and serological alterations and with alcohol drinking habits. The sPIIIP levels resulted significantly increased in 51% of 43 patients with untreated chronic active hepatitis (CAH), in 61% of 36 patients with CAH plus cirrhosis, in 69% of 26 patients with inactive cirrhosis, in 4 out of 8 patients with alcoholic steatosis and fibrillogenesis, but remained unchanged in 38 cases of alcoholic steatosis plus siderosis and in 13 cases of chronic persistent hepatitis. A correlation between sPIIIP levels and the histological pattern of fibrosis could not be demonstrated in a single type of fibrotic liver disease and no differences were found between alcoholic and non-alcoholic patients. We agree upon the opinion that high sPIIIP levels may identify liver fibrogenic activity, but this test needs further technical improvements before it could be widely used in the clinical practice.

Adult↗
PubMedDate not supplied

[The hypoglycemic reactions in diabetic patients in the emergency room. Which patients are going to be hospitalized?].

In one year, a retrospective study in a casualty department identified 67 hypoglycemic episodes occurring to adult diabetic patients: 40 insulin-treated, 20 oral antidiabetic-treated, 7 with unrecorded treatment. All the oral antidiabetic-treated patients were on glibenclamide and the mean dose was 6.5 mg/day: 35.7% of the patients admitted to the medical ward were discharged without antidiabetic drug prescription, suggesting that previous treatment had been unnecessary. Thirty one of the subjects had to be admitted to the medical ward: they were significantly older, mainly on oral antidiabetic treatment and their glucose blood levels were significantly lower than those of the patients treated in the casualty department and sent home. The subjects were admitted mainly because of associated disease, late complications of the diabetic status or home care shortage.

Adult↗
PubMedDate not supplied

[HBsAg frequency in asymptomatic heroin users living in Milan (author's transl)].

185 asymptomatic heroin addicts in whom the incidence of positivity as for HBsAg was 9.1%, were examined. From the anamnesis, these carriers has a higher frequency of icteric events in comparison with patient controls, while they did not show differences in distribution according to age, duration of the toxicomania and regional origin of the family. 38 heroin addicts were alcoholics too: 6/38 were HBs carriers, whereas 11/147 non alcoholic were carriers. The group of HBsAg positive addicts showed an analogous alteration of the transaminase levels as regards the patient controls, while the incidence of hypoalbuminemia and hypergammaglobulinemia was higher. In consideration of these results, the possible responsibility of toxic factors (alcohol) and alterations of the immune reactivity as to the prolonged permanence of HBsAg in circle is discussed.

Adolescent↗