Optimum method for growth hormone treatment.
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Calibration↗
Biomedical subjects
R N Wild
Publications and source records attributed to R N Wild.
Somatonorm post-marketing surveillance study (UK and Ireland, 1986-1987): a preliminary report.
A PMS study in the UK and Ireland recruited 581 children, mainly with GH deficiency, for treatment with Somatonorm and observation for 1 year; only 1 child proved totally non-evaluable. The mean dose prescribed was 0.41 IU/kg/week, with 56% of children receiving below the recommended dose. Underdosing was reflected particularly by the low growth rates of pubertal children. Somatonorm was safe, with a low incidence of reported events, of which lipoatrophy (in 6 cases) was the most common. Antibody assays were seldom requested and always negative.
Adolescent↗
Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man.
1 Plasma and biliary concentrations of amoxycillin and ceftriaxone were measured after bolus intravenous administration (500 mg) in four subjects with normal hepato-biliary and renal function. 2 The mean plasma elimination half-life for ceftriaxone (t 1/2 = 330 +/- 30 min) was considerably longer than that for amoxycillin (t 1/2 = 60 +/- 9 min). 3 The biliary concentration of ceftriaxone was above plasma concentration of the drug throughout the study period, whereas amoxycillin concentration in the bile was lower than that in plasma. 4 Both plasma and biliary concentrations of ceftriaxone were substantially higher than previously determined minimum inhibitory concentration (MIC) values for E. coli (and several other common biliary tract pathogens) for over 6 h following drug administration. Amoxycillin concentration in plasma fell below MIC by 2 h, and did not reach inhibitory concentrations in bile.
Adult↗
The pharmacokinetics and acceptability of benoxaprofen following rectal administration.
The bioavailability of a single 300 mg dose of benoxaprofen was compared after rectal and oral administration in 5 subjects. The total absorption rectally from a suppository was 83% of that achieved orally from a capsule. Six further subjects took a 300 mg benoxaprofen suppository twice daily for 12 d. Steady state plasma levels (mean level 94 microgram/ml) were reached at about 120 h, while the elimination half-life for benoxaprofen was approximately 38 h in this study. The suppositories were well tolerated. The plasma levels obtained compared very favorably with theoretically expected levels and levels obtained after comparable oral doses.
Absorption↗
Adder bites in children.
16 children with adder bites were admitted to hospital in Southampton in the years 1969--77. Two children were severely poisoned; these 2, and a 3rd, fulfilled suggested criteria for antivenom administration but they recovered without it. Three children had no treatment, and 9 children no analgesia. Prolonged morbidity was not seen in these children. Careful observation in hospital was the most important factor in management, with early clinical improvement obviating the need for antivenom.
Adolescent↗