Stress and the developmental cycle.
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Biomedical subjects
Publications and source records attributed to R N Miller.
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In recent years the quality of survival has become a more dominant factor in our treatment and management of patients with cancer. As a result, it has become necessary to think in terms of a multidisciplinary approach to total rehabilitation. A part of this rehabilitation is of necessity determined by the emotional responses that patients exhibit to their disease and to its treatment. A useful model that has been applied to patients with other diseases and to patients with other types of cancer seems equally applicable to patients with bladder cancer. In my work with cancer patients I became aware that, after the initial fear of death was dealt with, the patients all responded to their dilemma with stereotyped and predictable responses (emotional patterns of behavior). It was apparent that these responses were determined by the degree to which the patient's life style was altered by the disease and/or treatment.
Preliminary data on the biochemical effects of the transfusion of three units of CPD blood in man is presented. Free (ionized) calcium was found to decrease approximately two minutes following initiation of the transfusion of CPD stored blood at a rate of 50 ml/min. Due to mixing problems, arterial and not venous specimens were found necessary to monitor accurately the severity of these decreases. Parathyroid hormone in the peripheral blood was found to increase two to four minutes after the initiation of transfusion. Decreases in blood pressure were observed during transfusion. The blood pressure recovered when the transfusion was stopped and did not decrease any further after restarting the transfusion, were found out not to increase or decrease consistently, and only modest changes in plasma potassium were observed.
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A case of prolonged neuromuscular blockade associated with the administration of trimethaphan to a neurosurgical patient aged 29 is believed to be the possible result of interaction between trimethaphan, a ganglionic-blocking drug, and muscle relaxant. This possibility should be kept in mind when the administration of trimethaphan is being considered.
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