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Biomedical subjects

R N McGrew

Publications and source records attributed to R N McGrew.

11 recordsLinked to original sources
PubMed1981

Clinical applications of the CO2 laser in neoplastic lesions of the aerodigestive tract.

The use of the CO2 laser in otolaryngologic microsurgery offers the opportunity to reduce morbidity and deformity, and to decrease hospitalization time associated with resection of neoplasms of the oral cavity, pharynx, and larynx. We used the CO2 laser to resect a variety of lesions in 14 patients. Laser resection was the primary mode of therapy, in combination with irradiation and chemotherapy. Local control of the neoplasms was achieved with a number of advantages over established modes of therapy. The CO2 laser continues to show promise as a means of primary control in head and neck neoplasms, with a minimum of morbidity and deformity.

Adult↗
PubMed1981

Homograft septal cartilage for attic support in intact canal wall tympanomastoidectomy and tympanoplasty.

The postoperative formation of attic retraction pockets following tympanoplasty, with or without mastoidectomy, has often been a significant cause of recurrent disease accompanied by decreased hearing levels. Nasal septal cartilage is recommended as a successful homograft material for attic support. The basis and indications for its use are discussed. Preparation and storage of the homograft materials and surgical technique are described. Long-term results are reported, including a special group in which the status of the homograft material was assessed during revision surgery. Minimal complications have been encountered. Conclusions support the overall advantages of this technique utilizing homograft septal cartilage as an effective means of posterosuperior canal wall support, an aid in preventing retraction pocket formation.

Adolescent↗
PubMed1978

Bilateral retinal artery and choriocapillaris occlusion following the injection of long-acting corticosteroid suspensions in combination with other drugs: II. Animal experimental studies.

An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin. All five known long-acting corticosteroids, when combined with 1:1000,000 epinephrine, elicited vasoconstriction followed by dilatation of the retinal vessels with particulate material occlusion of the retinal vessels and choriocapillaris associated with small retinal hemorrhages. The fluorescein picture is described. The particles were identified by polarization as the long-acting corticosteroid.

Animals↗
PubMed1978

Bilateral retinal artery and choriocapillaris occlusion following the injection of long-acting corticosteroid suspensions in combination with other drugs: I. Clinical studies.

Two well-documented cases of bilateral retinal artery and choriocapillaris occlusions with blindness following head and neck soft-tissue injection with methylprednisolone acetate in combination with lidocaine, epinephrine, or penicillin are reported. One case had only a unilateral injection. The acute observations included hazy sensorium, superior gaze palsy, pupillary abnormalities, and conjunctival hemorrhages with edema. Follow-up changes showed marked visual loss, constricted visual fields, optic nerve pallor, vascular attenuation, and chorioretinal atrophy. The literature is reviewed, and possible causes are discussed.

Adult↗
PubMed1974

Epistaxis.

Explore the source record for details and available documents.

Epistaxis↗
PubMedDate not supplied

Sudden blindness secondary to injections of common drugs in the head and neck: I. Clinical experiences.

Several cases of sudden, irreversible blindness have been reported in the world literature following injections of various drug combinations in the head and neck. The common feature these drugs have is their capacity to either produce direct neurotoxic effects or embolic phenomena. Two new cases which resulted from injection of the combination of a depo or long-acting corticosteroid (methylprednisolone acetate, 40 mg) and a local anesthetic and epinephrine or penicillin were added to the growing world literature. The ocular and systemic pathologic findings are described and important questions are raised as to the pathophysiology. The need for an animal model experiment to answer as many of these questions as possible is emphasized.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Sudden blindness secondary to injections of common drugs in the head and neck: II. Animal studies.

The sudden occurrence of unilateral and bilateral blindness, as reported in the literature from the personal experiences of numerous qualified investigators, occurring in humans and producing such catastrophic effects seems to mandate experimental effort to try and answer three basic questions: (1) Can an animal model be found which will demonstrate similar retinopathy for study? (2) If such a model is found, what mechanisms are involved in the production of the retinal pathologic changes? (3) What are the characteristics of the drug or drug combinations necessary to produce these pathologic changes?

Adrenal Cortex Hormones↗