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Biomedical subjects

R N Gordon

Publications and source records attributed to R N Gordon.

7 recordsLinked to original sources
PubMed1999

Calcified scleral plaques imaged on orbital computed tomography.

PURPOSE: To identify calcified scleral plaques on orbital computed tomography. METHODS: We identified all orbital computed tomographic scans at one center from January 1, 1994, through December 31, 1994. Orbital computed tomographic scans of 145 patients were reviewed to determine the presence or absence of the typical appearance of calcified scleral plaques on film. RESULTS: Of the 145 scans reviewed, nine (6.2%) demonstrated calcified scleral plaques. Seven (22.6%) of 31 scans obtained on patients older than 70 years demonstrated calcified scleral plaques. CONCLUSIONS: Calcified plaques of the sclera commonly appear on orbital computed tomographic scans, especially in elderly patients. This entity should be included in the differential diagnosis of ocular calcifications. Familiarity with the computed tomographic findings of calcified scleral plaques may help ophthalmologists and radiologists distinguish them from intrascleral metallic foreign bodies.

Adolescent↗
PubMed1998

Lack of cross-reactive allergic response to brimonidine in patients with known apraclonidine allergy.

PURPOSE: To assess the allergenic potential of topical brimonidine 0.2% in patients shown to be allergic to apraclonidine 0.5%. METHODS: Eighteen glaucoma patients who developed allergy to apraclonidine were enrolled. Allergy was graded and documented photographically. Apraclonidine was then discontinued until the allergy resolved. Grading and photography were repeated, following which treatment with brimonidine was initiated. Patients were examined 1 h after the initial drop of brimonidine, twice weekly for 6 weeks, and at 3 monthly intervals thereafter. All other anti-glaucoma medications were continued. RESULTS: Mean patient age was 66.3 +/- 14.9 years (range 33.5-89.3 years). The mean time to apraclonidine allergy from initial exposure was 12.9 +/- 12.9 months (range 2.1-46.8 months). For the 10 patients rechallenged with apraclonidine, the mean time to allergy was 13.6 +/- 10.2 days (range 3-32 days). Mean duration of brimonidine therapy was 140.7 +/- 66.2 days (range 14-286 days), with 11 patients reaching at least 150 days of follow-up. Two patients developed symptomatic brimonidine allergy at 138 and 201 days respectively. For those patients who did not develop symptoms of allergy to brimonidine, there was no significant change in any of the parameters by which allergy was graded throughout the study. CONCLUSIONS: Patients with known apraclonidine allergy do not develop an early allergic response to brimonidine. These data rule against a cross-reactive allergic response between these two alpha 2-adrenoreceptor agonists.

Adrenergic alpha-Agonists↗
PubMed1997

Asymptomatic optic disc edema.

Non-arteritic anterior ischemic optic neuropathy (AION-na) classically presents with visual loss, altitudinal visual field defects, and optic nerve swelling. AION-na presumably occurs secondary to an ischemic event. Two patients are described who were at risk for developing AION-na. Both patients presented with optic disc edema but did not have visual loss or visual field defects. Neither patient developed visual loss or visual field defects in the affected eye throughout one and two years of follow-up respectively. The optic disc edema resolved spontaneously in both affected eyes. The clinical spectrum of AION-na could range from a "full-blown" classic attack to a minimal attack characterized by disc swelling without visual loss. The amount and distribution of disc ischemia determines the individual clinical picture. The failure of either affected eye in this study to develop symptoms likely represents a graded axonal atrophy with mechanical decompression of the optic nerve.

Aged↗
PubMed1969

Prolonged labour.

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Asphyxia Neonatorum↗