Biomedical subjects
Publications and source records attributed to R N Chakravarty.
T and B cell percentages and their blastogenic response to PPD and lepromin have been studied in 107 patients of various types of leprosy. T cell counts and their blastogenic response were found to be considerably lower in all types of leprosy as compared to the normal. The counts and stimulation were the lowest for lepromatous leprosy. B cell counts were unaltered in all types of leprosy.
Explore the source record for details and available documents.
Rats were subjected to common bile duct ligation, after which intermittent peritoneal dialysis with a buffered solution containing rat plasma proteins was carried out in an attempt to reduce plasma bilirubin levels. Plasma bilirubin increased significantly (P less than 0.01) on the seventh day and was still rising 12 days after ligation of the common bile duct. Dialysis was performed during the second postoperative week. Provided that rat plasma protein was present in the dialysing fluid, dialysis significantly reduced (P less than 0.01) the levels of total plasma bilirubin, conjugated bilirubin and serum GPT in the experimental animals.
The etiopathogenesis of granuloma formation in amebiasis is not known. An experimental study was carried out in 48 guinea pigs arranged into four groups, to assess the role of hypersensitivity in formation of amebic granuloma. Repeated intracecal inoculations of saline in Group I and mixed amebic and bacterial suspension in other groups were made. Animals in Group III were sensitized by amebic antigen and in Group IV by bacterial antigen before inoculations. Lesions produced in the amebic hypersensitive group of animals were notably different from those in other groups. A higher frequency of cecal ulceration and a significantly severe grade of cecal damage was seen in these animals. Extensive pericecal adhesions and marked thickening of the wall produced nodular lesions. Granulomas were formed with dense chronic inflammatory cell infiltration including fibroblasts.
Explore the source record for details and available documents.