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Biomedical subjects

R Murray

Publications and source records attributed to R Murray.

At least 289 records · Page 16Linked to original sources
PubMed1981

Tamoxifen and aminoglutethimide in the management of patients with advanced endometrial carcinoma not responsive to medroxyprogesterone.

Eleven patients with advanced endometrial carcinoma not responsive to medroxyprogesterone were entered into a trial of therapy with tamoxifen, aminoglutethimide or both in combination. Two patients had a complete response, 1 to aminoglutethimide and 1 to tamoxifen. One patient who initially had a partial response to tamoxifen but then relapsed, had a partial response to aminoglutethimide. Two patients had stable disease for 8 and 6 months on aminoglutethimide, and 1 patient who initially showed no response to tamoxifen has had stable disease for 14 months since addition of aminoglutethimide to therapy. The relative lack of toxicity of these drugs make their use attractive in the management of such patients.

Adenocarcinoma↗
PubMed1979

Psychiatrists' models of mental illness and their personal backgrounds.

Seventy-nine junior psychiatrists at the Maudsley Hospital answered 16 biographical questions and a 68-item questionnaire measuring attitudes to the psychoanalytical, biological, social, behavioural, and anti-medical models of mental illness. The psychoanalytical model was the most clearly defined and its adherents the most dogmatic, while those supporting the social model were the most eclectic. Sex, social class, education and political sympathy proved a poor guide to the orientation of the respondent. Individuals who had decided on a career in psychiatry before entering medical school were the most critical of the biological model. Biologically minded psychiatrists were older and, in contrast to Kreitman's findings, there was a shift from a psychoanalytical to a biological preference with increasing psychiatric experience. The importance of scientific attitudes in psychiatry was endorsed by biologically and behaviourally inclined psychiatrists but denigrated by supporters of the analytical approach. Adherents of the psychoanalytical model had as many academic qualifications as the biologically inclined, but had fewer publications and were less active in research. It appears that interest in psychoanalysis is antipathetic to the development of scientific attitudes conducive to research.

Age Factors↗
PubMed1979

Mortality of chrysotile asbestos workers at the Balangero Mine, Northern Italy.

The mortality from 1946 to 1975 of over 900 North Italian chrysotile asbestos workers first employed between 1930 and 1965 has been studied. Nine deaths were certified as attributable to asbestosis, and eleven to lung cancer. One death was attributed to mesothelioma of pleura but this diagnosis was not supported by histological examination. Comparison with the national figures for all Italy did not reveal an excess of deaths from lung cancer but during the last quinquennium of observation, the SMR for lung cancer rose to 206. Simulation experiments enabled a dust index in fibre/years to be attached to each man in the cohort. All but two of the deaths from lung cancer occurred in the higher exposure group. The relative risk of lung cancer in this group was 2.89. The eleven workers who died from lung cancer were all cigarette smokers. A further period of observation is required to monitor the mortality of the surviving workers.

Asbestos↗
PubMed1978

Effect of maternal hypothyroidism and triiodothyronine on the fetus and newborn in rats.

Of 36 adult female rats studied 19 were radiothyroidectomized; 3 weeks later all rats were bred. Radiothyroidectomized rats were divided into Groups I-III. Group I was untreated. Maternal weight gain was not noted until day 9 and was steady thereafter. Group III rats were treated with triiodothyronine up to the first day of pregnancy, but were hypothyroid during gestation (elevated TSH and low T3). Group II rats were treated with T3 up to the day of delivery. The pregnancy, its outcome, and TSH and T3 levels were similar to the normal controls (Group VI). Pregnancy, its outcome, and TSH and T3 levels were not different from controls when T3 was given to normal rats up to day 1 of pregnancy (Group IV). T3 concentrations were elevated in the normal rats which were given T3 continuously up to the day of delivery (Group V). However, the animals did not appear to be thyrotoxic and TSH was not suppressed. The size of the litters of Group I mothers was significantly less than in other groups and this difference may be attributed to an increased tendency to resorb implanted fetuses in untreated hypothyroid mothers. However, activity, day of eye opening weight gain, and TSH and T3 levels of the pups of all the groups were similar up to age 21 days. The data indicate the independence of the fetal pituitary-thyroid axis from maternal thyroidal status in rats.

Animals↗
PubMed1978

Estimating the need for additional primary care physicians.

A systems approach is used to assess the primary health care delivery system in Indiana. The output (office visits) of primary care physicians is estimated and compared with the demand for their services. Indexes of demand, supply, cost, and need are derived and used to determine the additional number of primary care physicians needed in each area. The results of this study are being used to encourage graduating medical students to practice in areas in need of additional primary medical care.

Health Planning↗
PubMed1977

A computer-based record and clinical monitoring system for ambulatory care.

The Regenstrief Medical Record system is a computer-based medical record system for ambulatory care which has been in operation since 1973. For each patient served, it contains a core medical record including most objective data (treatment records, lab, x-ray and EKG, etc.) and selected items of subjective data. Its supports the care of patients by presenting the clinical data in clear and compact reports and by reminding the physician about clinical conditions that need corrective action. The generation of these computer reminders is totally controlled by physician authored protocols. Each protocol defines an important clinical condition and the content of the reminder to be triggered when that condition occurs. Physician compliance to the standards implicit in these protocols is improved by this feedback. Patient data are captured by computerized ancillary services, (laboratory and outpatient pharmacy) and by manual techniques. Much of these data are recorded by hand (as marks or numbers) on computer-tailored forms which can be optically read by machine. This system represents a different approach to the difficult problems of efficiently using and maintaining patient records.

Ambulatory Care↗