The authors report on two cases of congenital thrombopenia with radial aplasia. Both children display several birth defects and a mild thrombopenia; hemorragic manifestations occured in the first case only. Megakaryoblastic to platelets series, as studied with electronic microscopy, show small-sized, "microcytic" and hypogranular megakaryocytes, displaying a maturative disorder (dysmegakaryocytopoiesis). In functional studies, platelets of the first patient show an imperfect nucleotidic release and do not agregate normally with ristocetin. The second case exhibits mostly a PF3 reduction. The variety of expression of the megakaryocytic-platelets disorders appears likewise in the skeletal and visceral malformations. The whole disorder could be ascribed to a pleiotropic abnormal gene with a variable expressivity.

Blood Platelets↗

PubMedDate not supplied

[Prolonged fever and latent tuberculous foci].

Two cases of prolonged fever are reported. In the first case a tuberculous abscess of the liver was considered after an ultrasonic examination of the periphery of an hepatic calcification discovered many years ago; a right hepatectomy confirmed the diagnosis. The second patient was treated twenty years ago for a tuberculous exsudative peritonitis. The pelvic examination showed a myoma. A computed body tomogram disclosed a picture of pyometritis. This was confirmed by laparotomy showing tuberculous salpingitis and pyometritis by praevia myoma.

Adult↗

PubMedDate not supplied

[Automated hemogram and myeloperoxidase deficiency. Analysis of 33 cases].

The daily use of the D Hemalog machine allowed us to recognize thirty-three cases of myeloperoxydase deficiency, on the basis of different "alarms", the most important of which is called LPX (Low Peroxydase). Some patients had a blood disease which was lacking among the other subjects. In no case the enzymatic defect has led to a clinical infection.

Blood Chemical Analysis↗

PubMedDate not supplied

[Erythrocyte deformability in diabetics. Effects of insulin. Relation to platelet aggregation].

Erythrocyte deformability is abnormal in diabetics and is closely related to the equilibrium of diabetes : in insulin dependent diabetics connected to an artificial pancreas, the alterations of erythrocyte deformability are quickly corrected after the administration of insulin. The study of platelet aggregation in whole blood, demonstrated that the impaired deformability of red cells was able to induce an hyperaggregability of platelets, phenomenon which vanished after correction of the erythrocyte abnormality. A good equilibrium of diabetes appears fundamental to avoid such abnormalities of erythrocytes and platelets and to prevent the microangiopathic disorders.

Diabetes Mellitus↗

PubMedDate not supplied

[Biological surveillance of streptokinase treatment].

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Blood Coagulation Tests↗