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Biomedical subjects

R Muratore

Publications and source records attributed to R Muratore.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Thrombopenia and radial aplasia: 2 cases with platelet function and ultrastructural studies of megakaryocytes and platelets (author's transl)].

The authors report on two cases of congenital thrombopenia with radial aplasia. Both children display several formative abnormalities and a mild thrombopenia; hemorragic manifestations occurred in the first case only. Megacryoblastic to platelets series, as studied with electronic microscopy, show small-sized, "microcytic" and hypogranular megacaryocytes, displaying a maturative disorder (dysmegacaryocytopoiesis). In functional studies, platelets of the first patient show an imperfect nucleotidic release and do not agregate normally with ristocetin. The second case exhibits mostly a PF3 reduction. The variety of expression of the megacaryocytic-platelets disorders appears likewise in the squelettal and visceral malformations. The whole disorder could be ascribed to a pleiotropic abnormal gene with a variable expressivity.

Blood Platelets↗
PubMed1978

[Practical aspects of the routine hospital use of the Hemalog D (author's transl)].

Five months experience with the Hemalog D has enabled the authors to define the mode of integration of the apparatus into a central hematology laboratory of a hospital without a clinical hematology department. The incidence and importance of such factors as the alarms set off by the apparatus, the time-course of blood basophils in patients receiving heparin and the clinical picture in patients for whom the apparatus revealed a peroxidase deficiency are discussed.

Autoanalysis↗
PubMed1978

[Histological lesions of the bone marrow in medullary aplasia. Results of a common protocol on 261 biopsies].

In a cooperative study on bone marrow aplasia, 261 bone marrow biopsies have been examined in triple blind. 13 cases were excluded for technical defect, and 37 cases (17%) excluded for erroneous diagnosis (myelofibrosis or leukemia). It remains 176 first biopsies and 35 second biopsies (10th or 20th month). A quantitative depletion of the marrow was observed in 87% of the cases, but in 13 a rich marrow gave way to discuss the morphological definition of marrow aplasia. Framework lesions (reticulin, vessels, bone) and cytologic modifications (histiocytic or plasmocytic infiltrations) have been appreciated, and their importance in the induction of aplasia and in the prognosis is emphasized. Comparison between first and second biopsy has shown a repletion of the marrow in two third of the cases, the early unfavourable character of reticulinic lesions, and the favourable signification of plasmocytosis. A more complete comparison between marrow histology and other parameters of the study will improve the knowledge of physiopathology and prognosis of marrow aplasia.

Anemia, Aplastic↗
PubMed1978

Histological prognosis in aplastic anaemia.

In the prognosis of aplastic anaemia, bone marrow biopsy displays several data which were unknown by the myelogram: quantitative evaluation of marrow cellularity; vascular and mesenchymatous lesions; extension of lymphoid or histiocytic infiltration. Nevertheless, the confrontation and value of these signs with the previously used prognosis data issued from clinical and haematological observations is still discussed. The lack of a clear understanding of the bone marrow failure delimitation is perhaps the reason of these differences. We present the histological results of a cooperative protocol concerning 350 cases of bone marrow failure with 220 first bone marrow biopsies examined in triple blind and confronted in a statistical comparison with the mortality in the first 20 months. We evidence the early unfavourable character of oedema and reticulin lesions: and the unconcerned character of cellularity, and lymphocytic and plasmocytic infiltration. These data must be taken into account in an allograft decision.

Anemia, Aplastic↗
PubMed1976

[Refractory anemia with partial myeloblastic medullary infiltration. Examination of marrow biopsies (author's transl)].

77 marrow biopsies of smouldering leukemia have been examined in triple blind fashion with the following results: the cellularity of the marrow is normal in three quarters of the cases. In one quarter the blast cells were homogenous, which confirms the diagnosis of leukemia. The frequences of the sheets of blast cells increase with the duration of the disease and reached 80% at the 20th month. In the other cases, blasts were seldom seen. Eosinophilia was frequent. Erythroblasts were always rare, in contrast to what is seen in sideroblastic anemias. The reticulin network was thickened in 25% of the cases. Thus, bone marrow biopsy may demonstrate many of the features supporting the diagnosis of smouldering leukemia.

Anemia, Aplastic↗