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Biomedical subjects

R Mouchette

Publications and source records attributed to R Mouchette.

30 records · Page 2Linked to original sources
PubMedDate not supplied

Giant fusiform aneurysm of the basilar artery. Clinico-pathological report of 3 cases.

From 9000 autopsies, three giant fusiform aneurysms of the basilar artery were found in middle-aged men with arterial hypertension, atherosclerosis, symptoms of encephalic circulatory disturbances, transient then permanent cranial nerves palsy. Neuroradiological investigations suggested a basilar dolichomegartery in one case. Anatomically, these unruptured giant aneurysms (respectively: 2, 2.5 and 4.5 cm largest transversal diameter) compressed the brainstem; a recent softening destroyed the midpons in one case, and both cerebral peduncles in another. A review of the literature underlined the paucity of similar cases, and the difficulty of differential diagnosis of giant basilar aneurysms detected only by neuroradiological investigations without anatomical verifications.

Adult↗
PubMedDate not supplied

[Progressive multifocal leukoencephalopathy after renal transplantation. Report of two cases].

Progressive multifocal leukoencephalopathy (PML) occurred in two patients after kidney transplantation. Two years after such a transplantation associated with immunosuppressive chemotherapy, a 54-year-old male developed polyneuropathy, diffuse alterations of the central nervous system and he died with the suspicion of hypertensive encephalopathy due to progressive renal failure. A 45-year-old female had kidney transplantation first complicated by Listeria monocytogenes meningoencephalitis. She was cured from this disease and had a satisfactory social rehabilitation for two years. Afterwards, she suffered from various neurological ailments, including epilepsy, that were attributed to combined renal failure and developing hydrocephalus. One year after the onset of these neurological symptoms, the grafted kidney was removed and chemotherapy was discontinued but she died a few weeks later. Both patients had typical PML. By electron microscopy, performed on formalin fixed brain tissue, intranuclear round particles (40-50 nm) could be recognized in the first case only. These two cases are confronted with the six published observations of PML following organ transplantation. The frequency of PML has been estimated at 1 for 5000 kidney transplantation, 1 for 2000 chronic lymphoid leukemia and 1 for 10,000 Hodgkin's disease.

Brain↗