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Biomedical subjects

R Mosimann

Publications and source records attributed to R Mosimann.

At least 91 records · Page 5Linked to original sources
PubMed1977

[4 cases of potassium enteropathy].

The oral use of enteric-coated potassium chloride (and apparently of its slow-release form too) to compensate potassium loss during thiazide diuretic treatment may engender ischemic enteropathy. This iatrogenic condition is linked to the vaso-active properties of KCl, which act on blood vessels often damaged by hypertension or chronic heart failure. Four observations are presented involving stenosing ulceration or perforation of the small bowel following oral KCl treatment. The main clinical, pathological and therapeutic aspects are discussed.

Aged↗
PubMed1977

[Value of Warren's distal spleno-renal shunt in the treatment of esophageal varicosities].

Analysis of 22 patients who underwent distal spleno-renal shunt shows that postoperative mortality is low, thrombosis of the shunt rare, and the risk of encephalopathy minimal. Decompression of esophageal varicositis is effective, but probably less marked and slower than after porta-caval shunt. Accordingly, distal spleno-renal shunt is not recommended as an emergency procedure.

Adult↗
PubMed1977

Efficacy and risks of the distal splenorenal shunt in the treatment of bleeding esophageal varices.

Analysis of twenty-two patients who underwent distal splenorenal anastomosis shows that the operative mortality and morbidity are low if the indications for the procedure are strictly adhered to. The decompression of the esophageal varicosities is effective, even in the presence of persistent varicosities. This decompression is probably less important and perhaps slower than after portacaval shunting, so we now do not recommend distal splenorenal shunting as an emergency operation. Thrombosis of the shunt is rare and related especially to local anatomic conditions and operative technic. Shunt thrombosis is an early complication that we observed on two occasions manifested by recurrence of hemorrhage. There does not appear to be an appreciable difference between the terminoterminal and terminolateral distal splenorenal anastomoses. The effect of ligation of the splenic artery in the hypersplenism is doubtful. The frequency of postanastomotic encephalopathy is minimal with this type of shunt. Liver function tests were little changed during the period of postoperative observation, but our results do not permit us to conclude that the distal spleno-renal anastomosis less unfavorably affects liver function than do classic shunts.

Adult↗
PubMed1977

[Splenic repercussions after Warren's distal spleno -renal shunt].

Volume and function of the spleen were checked in 14 patients 6 months to 7.5 years (average: 2.5 years) after Warren distal spleno-renal shunt. In addition to the shunt, the splenic artery was ligated proximally in 5 cases. Splenomegaly decreased in half of the patients. In 8 out of the 13 patients with preoperative hypersplenism, the latter improved or disappeared after operation. Increased splenomegaly or hypersplenism was never found postoperatively. Splenic effects of the distal spleno-renal shunt are related to the improvement of the venous stasis. Efficiency of the splenic artery ligation is so doubtful that we do not recommend such a procedure.

Adult↗
PubMed1977

[Elective decompression of esophageal varices using Warren's distal splenorenal bypass].

Distal spleno-renal anastomosis is worth consideration in the treatment of certain forms of portal hypertension, especially when there is a satisfactory portal blood flow. Apart from the low operative mortality and morbidity its main advantages are the preservation of portal hepatic blood flow, the reduction or suppression of which may have a deleterious effect on the liver, and also avoid or reduce to a minimum the risk of portal systemic encephalopathy, while producing effective decompression of the oesophageal varices. This operation is contra-indicated in presence of a greatly reduced or inversed portal blood flow, and also in cases of ascites or marked stasis of the splanchnic or retroperitoneal lymphatic network.

Adult↗
PubMed1976

[Bochdalek's hernia with pseudopleuritic and abdominal symptoms in the adult. Apropos of 1 case].

A case of Bochdalek diaphragmatic defect in a 48-year-old man is reported. Previous failure to diagnose the condition had resulted in a variety of diagnostic errors and associated inappropriate treatment. Diagnosis of this malformation, which is rarely encountered in the adult, presents no particular difficulty if care is taken to look for it by appropriate radiologic study. Surgical repair is usually an easy matter.

Diagnostic Errors↗
PubMed1976

[Prevention of diabetes in pancreatectomised dogs by autotransplantation of pancreatic tissue in the liver].

In 15 mongrel dogs, a mixture of exocrine and endocrine pancreatic tissue obtained by a simple procedure was implanted into the liver of the same animal through a branch of the portal vein. Five animals with partial pancreatectomy were used for a morphological study. In a second group of ten dogs, 5 delayed and 5 immediate pancreatectomies were performed. No diabetes appeared after the pancreatectomy. The subsequent blood glucose and insulin levels remained within or close to the normal range for several weeks in 9 animals and up to 10 months in a last one, still alive. In 9 out of 10 animals, the long term study was limited between 6 and 17 weeks by the development of a malnutrition syndrome with hepatic steatosis due to the lack of exocrine secretory function because of the pancreatectomy. The last animal still alive developed the malnutrition syndrome after a second complementary resection of a small pancreatic fragment left along the duodenum. This last animal without diabetes at the 45th week suggests that the endocrine function of the autotransplanted pancreatic tissue could be maintained over a long period of time.

Animals↗